protease, serine 3

Target id: 2399

Nomenclature: protease, serine 3

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for protease, serine 3 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 304 9p13 PRSS3 protease, serine 3
Mouse - 246 6 B1 Prss3 protease, serine 3
Rat - - q22 LOC679835 similar to Anionic trypsin II precursor (Pretrypsinogen II)
Previous and Unofficial Names
mesotrypsin | MTG | PRSS4 | Try3 | TRY4 | trypsin 3 | trypsinogen 15 | protease, serine, 3
Database Links
Specialist databases
MEROPS S01.174 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.4

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
BPTI-K15R/R17G Hs Inhibition 8.2 pKi 1
pKi 8.2 (Ki 5.9x10-9 M) [1]
Inhibitor Comments
BPTI-K15R/R17G retains inhibitory activity towards human cationic trypsin and human anionic trypsin, but activity is weakened compared to wild type BPTI [1].

References

Show »

1. Salameh MA, Soares AS, Hockla A, Radisky DC, Radisky ES. (2011) The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. Biochem. J.440 (1): 95-105. [PMID:21806544]

How to cite this page

S1: Chymotrypsin: protease, serine 3. Last modified on 14/03/2017. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2399.