Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	212	15q23	SENP8	SUMO peptidase family member, NEDD8 specific
Mouse	-	221	9 B	Senp8	SUMO peptidase family member, NEDD8 specific
Rat	-	217	8q24	Senp8	SUMO peptidase family member, NEDD8 specific

Previous and Unofficial Names

deneddylase 1 | Den1 | NEDD8-specific protease 1 | Nedp1 | Prsc2 | sentrin-specific protease 8 | SUMO/sentrin specific peptidase family member 8 | SUMO/sentrin peptidase family member, NEDD8 specific | SUMO/sentrin peptidase family member | SUMO peptidase family member

Database Links
Specialist databases
MEROPS	C48.011 (Hs)
Other databases
Alphafold	Q96LD8 (Hs), Q9D2Z4 (Mm), Q5FVJ8 (Rn)
BRENDA	3.4.22.68
ChEMBL Target	CHEMBL1741207 (Hs)
Ensembl Gene	ENSG00000166192 (Hs), ENSMUSG00000051705 (Mm), ENSRNOG00000011595 (Rn)
Entrez Gene	123228 (Hs), 71599 (Mm), 315723 (Rn)
Human Protein Atlas	ENSG00000166192 (Hs)
KEGG Enzyme	3.4.22.68
KEGG Gene	hsa:123228 (Hs), mmu:71599 (Mm), rno:315723 (Rn)
OMIM	608659 (Hs)
Pharos	Q96LD8 (Hs)
RefSeq Nucleotide	NM_145204 (Hs), NM_001166340 (Hs), NM_001172109 (Hs), NM_001172110 (Hs), NM_001172111 (Hs), NM_027838 (Mm), NM_001172068 (Mm), NM_001172069 (Mm), NM_001172070 (Mm), NM_001172071 (Mm), NM_001012355 (Rn)
RefSeq Protein	NP_660205 (Hs), NP_001165582 (Hs), NP_001165581 (Hs), NP_001165580 (Hs), NP_001159812 (Hs), NP_001165539 (Mm), NP_082114 (Mm), NP_001165542 (Mm), NP_001165541 (Mm), NP_001165540 (Mm), NP_001012355 (Rn)
UniProtKB	Q96LD8 (Hs), Q9D2Z4 (Mm), Q5FVJ8 (Rn)
Wikipedia	SENP8 (Hs)

Enzyme Reaction
EC Number: 3.4.22.68

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ST074946 Hs Inhibition 7.8 pIC50 1 ⤷ pIC50 7.8 (IC50 1.73x10-8 M) [1]