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SUMO peptidase family member, NEDD8 specific

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Target not currently curated in GtoImmuPdb

Target id: 2417

Nomenclature: SUMO peptidase family member, NEDD8 specific

Family: C48: Ulp1 endopeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 212 15q23 SENP8 SUMO peptidase family member, NEDD8 specific
Mouse - 221 9 B Senp8 SUMO peptidase family member, NEDD8 specific
Rat - 217 8q24 Senp8 SUMO peptidase family member, NEDD8 specific
Previous and Unofficial Names Click here for help
deneddylase 1 | Den1 | NEDD8-specific protease 1 | Nedp1 | Prsc2 | sentrin-specific protease 8 | SUMO/sentrin specific peptidase family member 8 | SUMO/sentrin peptidase family member, NEDD8 specific | SUMO/sentrin peptidase family member | SUMO peptidase family member
Database Links Click here for help
Specialist databases
MEROPS C48.011 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ST074946 Small molecule or natural product Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.73x10-8 M) [1]


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1. Salvesen G. Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate - BioAssay Summary. Accessed on 06/09/2013. Modified on 06/09/2013. PubChem,

How to cite this page

C48: Ulp1 endopeptidase: SUMO peptidase family member, NEDD8 specific. Last modified on 27/02/2018. Accessed on 11/08/2022. IUPHAR/BPS Guide to PHARMACOLOGY,