SUMO peptidase family member, NEDD8 specific

Target id: 2417

Nomenclature: SUMO peptidase family member, NEDD8 specific

Family: C48: Ulp1 endopeptidase

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for SUMO peptidase family member, NEDD8 specific in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 212 15q22.33 SENP8 SUMO peptidase family member, NEDD8 specific
Mouse - 234 9 C Senp8 SUMO/sentrin specific peptidase 8
Rat - 217 8q24 Senp8 SUMO/sentrin peptidase family member, NEDD8 specific
Previous and Unofficial Names
deneddylase 1 | Den1 | NEDD8-specific protease 1 | Nedp1 | Prsc2 | sentrin-specific protease 8 | SUMO/sentrin specific peptidase family member 8 | SUMO/sentrin peptidase family member, NEDD8 specific | SUMO/sentrin peptidase family member
Database Links
Specialist databases
MEROPS C48.011 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ST074946 Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.73x10-8 M) [1]


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1. Salvesen G. Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate - BioAssay Summary. Accessed on 06/09/2013. Modified on 06/09/2013. PubChem,

How to cite this page

C48: Ulp1 endopeptidase: SUMO peptidase family member, NEDD8 specific. Last modified on 27/02/2018. Accessed on 25/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY,