SUMO/sentrin peptidase family member, NEDD8 specific

Target id: 2417

Nomenclature: SUMO/sentrin peptidase family member, NEDD8 specific

Family: C48: Ulp1 endopeptidase

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for SUMO/sentrin peptidase family member, NEDD8 specific in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 212 15q22.33 SENP8 SUMO/sentrin peptidase family member, NEDD8 specific
Mouse - 234 9 C Senp8 SUMO/sentrin specific peptidase 8
Rat - 217 8q24 Senp8 SUMO/sentrin peptidase family member
Previous and Unofficial Names
deneddylase 1 | Den1 | NEDD8-specific protease 1 | Nedp1 | Prsc2 | sentrin-specific protease 8 | SUMO/sentrin specific peptidase family member 8 | SUMO/sentrin peptidase family member
Database Links
Specialist databases
MEROPS C48.011 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.68

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ST074946 Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.73x10-8 M) [1]

References

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1. Salvesen G. Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate - BioAssay Summary. Accessed on 06/09/2013. Modified on 06/09/2013. PubChem, http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=651559

How to cite this page

C48: Ulp1 endopeptidase: SUMO/sentrin peptidase family member, NEDD8 specific. Last modified on 30/07/2015. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2417.