transmembrane protease, serine 11D

Target id: 2420

Nomenclature: transmembrane protease, serine 11D

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for transmembrane protease, serine 11D in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 418 4q13.2 TMPRSS11D transmembrane protease, serine 11D
Mouse - 417 5 E1 Tmprss11d transmembrane protease
Rat - 417 14p21 Tmprss11d transmembrane protease
Previous and Unofficial Names
AT | adrenal secretory serine protease | airway trypsin-like protease | Asp | AST | transmembrane protease, serine 11d | transmembrane protease
Database Links
Specialist databases
MEROPS S01.047 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.-

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
inhibitor 1 [Colombo et al., 2012] Hs Inhibition 8.1 pKi 1
pKi 8.1 (Ki 8.4x10-9 M) [1]
compound 5 [PMID: 21741839] Hs Inhibition 7.7 pKi 2
pKi 7.7 (Ki 1.9x10-8 M) [2]

References

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1. Colombo E, Desilets A, Duchene D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and Synthesis of Potent, Selective Inhibitors of Matriptase. ACS Med.Chem.Lett.3: 530-534.

2. Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T. (2011) Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg. Med. Chem. Lett.21 (16): 4860-4. [PMID:21741839]

How to cite this page

S1: Chymotrypsin: transmembrane protease, serine 11D. Last modified on 28/07/2015. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2420.