transmembrane serine protease 2

Target id: 2421

Nomenclature: transmembrane serine protease 2

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for transmembrane serine protease 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 492 21q22.3 TMPRSS2 transmembrane serine protease 2
Mouse - 490 16 C2 Tmprss2 transmembrane protease, serine 2
Rat - 490 11q12 Tmprss2 transmembrane protease, serine 2
Previous and Unofficial Names
epitheliasin | plasmic transmembrane protein X | PRSS10 | transmembrane protease, serine 2 | transmembrane protease
Database Links
Specialist databases
MEROPS S01.247 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 5 [PMID: 21741839] Hs Inhibition 7.7 pKi 1
pKi 7.7 (Ki 2x10-8 M) [1]


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1. Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T. (2011) Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg. Med. Chem. Lett.21 (16): 4860-4. [PMID:21741839]

How to cite this page

S1: Chymotrypsin: transmembrane serine protease 2. Last modified on 27/02/2018. Accessed on 17/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,