transmembrane protease, serine 2

Target id: 2421

Nomenclature: transmembrane protease, serine 2

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for transmembrane protease, serine 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 492 21q22.3 TMPRSS2 transmembrane protease, serine 2
Mouse - 490 16 C2 Tmprss2 transmembrane protease
Rat - 490 11q12 Tmprss2 transmembrane protease
Previous and Unofficial Names
epitheliasin | plasmic transmembrane protein X | PRSS10 | transmembrane protease
Database Links
Specialist databases
MEROPS S01.247 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 5 [PMID: 21741839] Hs Inhibition 7.7 pKi 1
pKi 7.7 (Ki 2x10-8 M) [1]


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1. Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T. (2011) Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg. Med. Chem. Lett.21 (16): 4860-4. [PMID:21741839]

How to cite this page

S1: Chymotrypsin: transmembrane protease, serine 2. Last modified on 28/07/2015. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY,