transmembrane protease, serine 6

Target id: 2422

Nomenclature: transmembrane protease, serine 6

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for transmembrane protease, serine 6 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 811 22q13.1 TMPRSS6 transmembrane protease, serine 6
Mouse - 811 15 E2 Tmprss6 transmembrane serine protease 6
Rat - 772 7q34 Tmprss6 transmembrane protease
Previous and Unofficial Names
matriptase 2 | transmembrane protease serine 6 | transmembrane protease
Database Links
Specialist databases
MEROPS S01.308 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
inhibitor 1 [Colombo et al., 2012] Hs Inhibition 8.5 pKi 1
pKi 8.5 (Ki 3.3x10-9 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Iron-refractory iron deficiency anemia; IRIDA
Synonyms: IRIDA syndrome [Orphanet: ORPHA209981]
OMIM: 206200
Orphanet: ORPHA209981


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1. Colombo E, Desilets A, Duchene D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and Synthesis of Potent, Selective Inhibitors of Matriptase. ACS Med.Chem.Lett.3: 530-534.

How to cite this page

S1: Chymotrypsin: transmembrane protease, serine 6. Last modified on 22/07/2015. Accessed on 26/02/2018. IUPHAR/BPS Guide to PHARMACOLOGY,