sphingomyelin synthase 2

Target id: 2521

Nomenclature: sphingomyelin synthase 2

Family: Sphingomyelin synthase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for sphingomyelin synthase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 365 4q25 SGMS2 sphingomyelin synthase 2
Mouse - 365 3 G3 Sgms2 sphingomyelin synthase 2
Rat - 365 2q43 Sgms2 sphingomyelin synthase 2
Previous and Unofficial Names
Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SMS2
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.8.27 ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound D24 [PMID: 24374347] Hs Inhibition 4.9 pIC50 1
pIC50 4.9 (IC50 1.24x10-5 M) [1]

References

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1. Deng X, Lin F, Zhang Y, Li Y, Zhou L, Lou B, Li Y, Dong J, Ding T, Jiang X et al.. (2014) Identification of small molecule sphingomyelin synthase inhibitors. Eur J Med Chem73: 1-7. [PMID:24374347]

How to cite this page

Sphingomyelin synthase: sphingomyelin synthase 2. Last modified on 23/09/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2521.