sphingomyelin synthase 2

Target id: 2521

Nomenclature: sphingomyelin synthase 2

Family: Sphingomyelin synthase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for sphingomyelin synthase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 365 4q25 SGMS2 sphingomyelin synthase 2
Mouse - 365 3 G3 Sgms2 sphingomyelin synthase 2
Rat - 365 2q43 Sgms2 sphingomyelin synthase 2
Previous and Unofficial Names
Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SMS2
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound D24 [PMID: 24374347] Hs Inhibition 4.9 pIC50 1
pIC50 4.9 (IC50 1.24x10-5 M) [1]


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1. Deng X, Lin F, Zhang Y, Li Y, Zhou L, Lou B, Li Y, Dong J, Ding T, Jiang X et al.. (2014) Identification of small molecule sphingomyelin synthase inhibitors. Eur J Med Chem, 73: 1-7. [PMID:24374347]

How to cite this page

Sphingomyelin synthase: sphingomyelin synthase 2. Last modified on 23/09/2015. Accessed on 16/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2521.