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fatty acid binding protein 3

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Target not currently curated in GtoImmuPdb

Target id: 2533

Nomenclature: fatty acid binding protein 3

Family: Fatty acid-binding proteins

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 133 1p35.2 FABP3 fatty acid binding protein 3
Mouse - 133 4 63.43 cM Fabp3 fatty acid binding protein 3, muscle and heart
Rat - 133 5q36 Fabp3 fatty acid binding protein 3
Previous and Unofficial Names Click here for help
MDGI | FABP11 | Fabph1 | Fabph4 | fatty acid binding protein 11 | H-FABP | mammary-derived growth inhibitor
Database Links Click here for help
Alphafold P05413 (Hs), P11404 (Mm), P07483 (Rn)
CATH/Gene3D 2.40.128.20
ChEMBL Target CHEMBL3344 (Hs)
Ensembl Gene ENSG00000121769 (Hs), ENSMUSG00000028773 (Mm), ENSRNOG00000012879 (Rn)
Entrez Gene 2170 (Hs), 14077 (Mm), 79131 (Rn)
Human Protein Atlas ENSG00000121769 (Hs)
KEGG Gene hsa:2170 (Hs), mmu:14077 (Mm), rno:79131 (Rn)
OMIM 134651 (Hs)
Pharos P05413 (Hs)
RefSeq Nucleotide NM_004102 (Hs), NM_010174 (Mm), NM_024162 (Rn)
RefSeq Protein NP_004093 (Hs), NP_034304 (Mm), NP_077076 (Rn)
UniProtKB P05413 (Hs), P11404 (Mm), P07483 (Rn)
Wikipedia FABP3 (Hs)
Rank order of potency (Human)
stearic acid, oleic acid, palmitic acid > linoleic acid, α-linolenic acid, arachidonic acid  [1]

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 13 [PMID: 17502136] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.4 pKi 2
⤷ pKi 8.4 (Ki 4x10-9 M) [2]

References

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1. Richieri GV, Ogata RT, Kleinfeld AM. (1994) Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. J Biol Chem, 269 (39): 23918-30. [PMID:7929039]

2. Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R et al.. (2007) Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg Med Chem Lett, 17 (12): 3511-5. [PMID:17502136]

How to cite this page

Fatty acid-binding proteins: fatty acid binding protein 3. Last modified on 12/07/2018. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2533.