fatty acid binding protein 4

Target id: 2534

Nomenclature: fatty acid binding protein 4

Family: Fatty acid-binding proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for fatty acid binding protein 4 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 132 8q21.13 FABP4 fatty acid binding protein 4
Mouse - 132 3 A1 Fabp4 fatty acid binding protein 4, adipocyte
Rat - 132 2q23 Fabp4 fatty acid binding protein 4
Previous and Unofficial Names
adipocyte lipid-binding protein | adipocyte protein aP2 | AFABP | ALBP
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of mouse adipocyte fatty acid binding ptortin bound by inhibitor.
PDB Id:  3HK1
Ligand:  HTS01037
Resolution:  1.7Å
Species:  Mouse
References:  1
Rank order of potency (Human)
oleic acid, palmitic acid, stearic acid, linoleic acid > α-linolenic acid, arachidonic acid  [3]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
HM50316 Hs Inhibition >9.0 pKi 2
pKi >9.0 (Ki <1x10-9 M) [2]
compound 13 [PMID: 17502136] Hs Inhibition 8.7 pKi 4
pKi 8.7 (Ki 2x10-9 M) [4]
HTS01037 Mm Inhibition 6.2 pKi 1
pKi 6.2 (Ki 6.7x10-7 M) [1]
View species-specific inhibitor tables

References

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1. Hertzel AV, Hellberg K, Reynolds JM, Kruse AC, Juhlmann BE, Smith AJ, Sanders MA, Ohlendorf DH, Suttles J, Bernlohr DA. (2009) Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. J. Med. Chem.52 (19): 6024-31. [PMID:19754198]

2. Liu X, Huang X, Lin W, Wang D, Diao Y, Li H, Hui X, Wang Y, Xu A, Wu D et al.. (2011) New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg. Med. Chem. Lett.21 (10): 2949-52. [PMID:21481589]

3. Richieri GV, Ogata RT, Kleinfeld AM. (1994) Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. J. Biol. Chem.269 (39): 23918-30. [PMID:7929039]

4. Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R et al.. (2007) Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg. Med. Chem. Lett.17 (12): 3511-5. [PMID:17502136]

How to cite this page

Fatty acid-binding proteins: fatty acid binding protein 4. Last modified on 29/01/2016. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2534.