coagulation factor V

Target id: 2606

Nomenclature: coagulation factor V

Family: Blood coagulation components

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for coagulation factor V in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2224 1q23 F5 coagulation factor V
Mouse - 2183 1 H2.2 F5 coagulation factor V
Rat - 1942 13q22 F5 coagulation factor V
Previous and Unofficial Names
coagulation factor V (proaccelerin, labile factor)
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the C2 domain of human coagulation factor V
PDB Id:  1CZT
Resolution:  1.87Å
Species:  Human
References:  3

Download all structure-activity data for this target as a CSV file

Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
drotrecogin alfa Hs Inhibition - - 1-2
Antithrombotic effect thought to occur via inhibition of factors Va and VIIIa [1-2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Budd-Chiari syndrome
OMIM: 600880
Orphanet: ORPHA131
Disease:  Cerebral sinovenous thrombosis
Orphanet: ORPHA329217
Disease:  Factor V deficiency
Disease Ontology: DOID:2216
OMIM: 227400
Orphanet: ORPHA326
Disease:  Pregnancy loss, recurrent, susceptibility to, 1
OMIM: 614389
Disease:  Stroke, ischemic
Synonyms: Cerebral infarction
Cerebrovascular accident [Disease Ontology: DOID:3455]
Disease Ontology: DOID:3455
OMIM: 601367
Disease:  Thrombophilia due to activated protein C resistance
Synonyms: Thrombophilia [Disease Ontology: DOID:2452]
Disease Ontology: DOID:2452
OMIM: 188055

References

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1. Kanji S, Devlin JW, Piekos KA, Racine E. (2001) Recombinant human activated protein C, drotrecogin alfa (activated): a novel therapy for severe sepsis. Pharmacotherapy21 (11): 1389-402. [PMID:11714212]

2. Kapur S, Kupfer Y, Tessler S. (2001) Recombinant human activated protein C for severe sepsis. N. Engl. J. Med.345 (3): 219-20; author reply 220-1. [PMID:11463021]

3. Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH et al.. (1999) Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Nature402 (6760): 434-9. [PMID:10586886]

How to cite this page

Blood coagulation components: coagulation factor V. Last modified on 29/01/2016. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2606.