4-hydroxyphenylpyruvate dioxygenase

Target id: 2621

Nomenclature: 4-hydroxyphenylpyruvate dioxygenase

Family: 1.-.-.- Oxidoreductases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for 4-hydroxyphenylpyruvate dioxygenase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 393 12q24.31 HPD 4-hydroxyphenylpyruvate dioxygenase
Mouse - 393 5 F Hpd 4-hydroxyphenylpyruvic acid dioxygenase
Rat - 393 12q16 Hpd 4-hydroxyphenylpyruvate dioxygenase
Previous and Unofficial Names
4HPPD | GLOD3
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase
PDB Id:  3ISQ
Resolution:  1.75Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 1.13.11.27

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
nitisinone Pig Inhibition 7.4 pIC50 1
pIC50 7.4 (IC50 4x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hawkinsinuria
OMIM: 140350
Orphanet: ORPHA2118
Disease:  Tyrosinemia, type III
Disease Ontology: DOID:0050727
OMIM: 276710
Orphanet: ORPHA69723

References

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1. Lin YL, Wu CS, Lin SW, Yang DY. (2000) SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg. Med. Chem. Lett.10 (9): 843-5. [PMID:10853644]

How to cite this page

1.-.-.- Oxidoreductases: 4-hydroxyphenylpyruvate dioxygenase. Last modified on 13/08/2015. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2621.