lysine demethylase 5C

Target id: 2682

Nomenclature: lysine demethylase 5C

Family: 1.14.11.- Histone demethylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for lysine demethylase 5C in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1560 Xp11.22-p11.21 KDM5C lysine demethylase 5C
Mouse - 1551 X F2-F4 Kdm5c lysine (K)-specific demethylase 5C
Rat - - Xq21 Kdm5c lysine demethylase 5C
Previous and Unofficial Names
JARID1C | SMCX | MRX13 | jumonji AT rich interactive domain 1C | mental retardation X-linked 13 | lysine (K)-specific demethylase 5C
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
IOX2 Hs Inhibition 6.8 pIC50 1
pIC50 6.8 (IC50 1.59x10-7 M) [1]
GSK-J1 Hs Inhibition 6.3 pIC50 2
pIC50 6.3 (IC50 5.5x10-7 M) [2]
PBIT Hs Inhibition 5.3 pIC50 4
pIC50 5.3 (IC50 4.9x10-6 M) [4]
GSK-J4 Hs Inhibition 4.8 pIC50 2
pIC50 4.8 (IC50 1.5x10-5 M) [2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Syndromic X-linked mental retardation due to JARID1C mutation
Description: This syndrome is characterised by mild to severe intellectual deficit associated with variable clinical manifestations including spasticity, cryptorchidism, maxillary hypoplasia, alopecia areata, epilepsy, short stature, impaired speech and behavioural problems.
Synonyms: Mental retardation, X-linked, syndromic, Claes-Jensen type
OMIM: 300534
Orphanet: ORPHA85279
Comments: 
References:  3,5

References

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1. Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A et al.. (2013) Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem. Biol.8 (7): 1488-96. [PMID:23683440]

2. Heinemann B, Nielsen JM, Hudlebusch HR, Lees MJ, Larsen DV, Boesen T, Labelle M, Gerlach LO, Birk P, Helin K. (2014) Inhibition of demethylases by GSK-J1/J4. Nature514 (7520): E1-2. [PMID:25279926]

3. Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. (2007) The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell128 (6): 1077-88. [PMID:17320160]

4. Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel JS, Yan Q. (2013) Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J. Biol. Chem.288 (13): 9408-17. [PMID:23408432]

5. Tzschach A, Lenzner S, Moser B, Reinhardt R, Chelly J, Fryns JP, Kleefstra T, Raynaud M, Turner G, Ropers HH et al.. (2006) Novel JARID1C/SMCX mutations in patients with X-linked mental retardation. Hum. Mutat.27 (4): 389. [PMID:16541399]

How to cite this page

1.14.11.- Histone demethylases: lysine demethylase 5C. Last modified on 30/03/2016. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2682.