ABCC9 | ABCC subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

ABCC9

Target id: 2746

Nomenclature: ABCC9

Abbreviated Name: SUR2

Family: ABCC subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ABCC9 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1549 12p12.1 ABCC9 ATP binding cassette subfamily C member 9
Mouse - 1546 6 G2 Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Rat - 1545 4q44 Abcc9 ATP binding cassette subfamily C member 9
Previous and Unofficial Names
CDMD10 | sulfonylurea receptor 2 | SUR2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | ATP-binding cassette, subfamily C (CFTR/MRP), member 9 | ATP-binding cassette
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 13b [PMID: 19101153] Hs Positive 6.2 pEC50 2
pEC50 6.2 (EC50 6.7x10-7 M) Compound 13b is a channel opener. [2]
Allosteric Modulator Comments
Compound 13b [PMID: 19101153] is most likely to bind the SUR2 [1] component of the ATP-sensitive potassium channel on smooth muscle cells, causing increased channel opening and cellular hyperpolarisation.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Atrial fibrillation, familial, 12; ATFB12
Synonyms: Familial atrial fibrillation [Orphanet: ORPHA334] [Disease Ontology: DOID:0050650]
Disease Ontology: DOID:0050650
OMIM: 614050
Orphanet: ORPHA334
Disease:  Cantu Syndrome
Synonyms: Hypertrichotic osteochondrodysplasia, Cantu type [Orphanet: ORPHA1517]
OMIM: 239850
Orphanet: ORPHA1517
Disease:  Cardiomyopathy, dilated, 1O; CMD1O
Synonyms: Dilated cardiomyopathy [Disease Ontology: DOID:12930]
Familial isolated dilated cardiomyopathy [Orphanet: ORPHA154]
Disease Ontology: DOID:12930
OMIM: 608569
Orphanet: ORPHA154

References

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1. Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, Matsuzawa Y, Kurachi Y. (1996) A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel. J. Biol. Chem., 271 (40): 24321-4. [PMID:8798681]

2. Zhang X, Qiu Y, Li X, Bhattacharjee S, Woods M, Kraft P, Lundeen SG, Sui Z. (2009) Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence. Bioorg. Med. Chem., 17 (2): 855-66. [PMID:19101153]

How to cite this page

ABCC subfamily: ABCC9. Last modified on 05/02/2018. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2746.