kelch like ECH-associated protein 1

Target id: 2757

Nomenclature: kelch like ECH-associated protein 1

Family: Kelch-like proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kelch like ECH-associated protein 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 624 19p13.2 KEAP1 kelch like ECH associated protein 1
Mouse - 624 9 A3 Keap1 kelch-like ECH-associated protein 1
Rat - 620 8q13 Keap1 Kelch-like ECH-associated protein 1
Previous and Unofficial Names
INrf2 | kelch-like ECH-associated protein 1
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
Nrf2 peptide [PMID: 23647822] Hs Binding 7.5 pIC50 1
pIC50 7.5 (IC50 3.3x10-8 M) [1]

References

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1. Marcotte D, Zeng W, Hus JC, McKenzie A, Hession C, Jin P, Bergeron C, Lugovskoy A, Enyedy I, Cuervo H et al.. (2013) Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism. Bioorg. Med. Chem.21 (14): 4011-9. [PMID:23647822]

How to cite this page

Kelch-like proteins: kelch like ECH-associated protein 1. Last modified on 29/01/2016. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2757.