L3MBTL3, histone methyl-lysine binding protein

Target id: 2830

Nomenclature: L3MBTL3, histone methyl-lysine binding protein

Family: Methyllysine reader proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for L3MBTL3, histone methyl-lysine binding protein in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 780 6q23 L3MBTL3 L3MBTL3, histone methyl-lysine binding protein
Mouse - 883 10 A4 L3mbtl3 L3MBTL3 histone methyl-lysine binding protein
Rat - - 1p12 L3mbtl3 L3MBTL3
Gene and Protein Information Comments
A shorter isoform of human L3MBTL3 (isoform b, 755 amino acids; NP_001007103) is reported.
Previous and Unofficial Names
l(3)mbt-like 3 (Drosophila) | lethal(3)malignant brain tumor-like protein 3 | MBT-1 | MBT1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215
PDB Id:  4FL6
Ligand:  UNC1215
Resolution:  2.55Å
Species:  Human

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
UNC1215 Hs Agonist 6.9 pKd 1
pKd 6.9 (Kd 1.2x10-7 M) [1]


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1. James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W et al.. (2013) Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat. Chem. Biol.9 (3): 184-91. [PMID:23292653]

How to cite this page

Methyllysine reader proteins: L3MBTL3, histone methyl-lysine binding protein. Last modified on 18/08/2017. Accessed on 22/02/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2830.