MCL1, BCL2 family apoptosis regulator

Target id: 2847

Nomenclature: MCL1, BCL2 family apoptosis regulator

Abbreviated Name: Mcl-1

Family: B-cell lymphoma 2 (Bcl-2) protein family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for MCL1, BCL2 family apoptosis regulator in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 350 1q21 MCL1 MCL1, BCL2 family apoptosis regulator
Mouse - 331 3 F2.1 Mcl1 myeloid cell leukemia sequence 1
Rat - 330 2q34 Mcl1 MCL1, BCL2 family apoptosis regulator
Previous and Unofficial Names
myeloid cell leukemia 1 | BCL2 family apoptosis regulator
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
venetoclax Hs Antagonist <6.3 pKi 1
pKi <6.3 (Ki >4.44x10-7 M) [1]

References

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1. Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J, Dayton BD, Ding H, Enschede SH, Fairbrother WJ et al.. (2013) ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat. Med.19 (2): 202-8. [PMID:23291630]

How to cite this page

B-cell lymphoma 2 (Bcl-2) protein family: MCL1, BCL2 family apoptosis regulator. Last modified on 21/03/2017. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2847.