prolyl endopeptidase like

Target id: 2870

Nomenclature: prolyl endopeptidase like

Family: S9: Prolyl oligopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for prolyl endopeptidase like in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 727 2p22.1 PREPL prolyl endopeptidase like
Mouse - 725 17 E4 Prepl prolyl endopeptidase-like
Rat - 638 6q12 Prepl prolyl endopeptidase-like
Previous and Unofficial Names
prolyl endopeptidase-like
Database Links
Specialist databases
MEROPS S09.015 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 8 [PMID: 21692504] Mm Inhibition 5.2 pIC50 1
pIC50 5.2 (IC50 6x10-6 M) [1]
Description: In a substrate free assay.


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1. Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF et al.. (2011) A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. J. Am. Chem. Soc., 133 (30): 11665-74. [PMID:21692504]

How to cite this page

S9: Prolyl oligopeptidase: prolyl endopeptidase like. Last modified on 27/02/2018. Accessed on 20/08/2018. IUPHAR/BPS Guide to PHARMACOLOGY,