prolyl endopeptidase-like

Target id: 2870

Nomenclature: prolyl endopeptidase-like

Family: S9: Prolyl oligopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for prolyl endopeptidase-like in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 727 2p22.1 PREPL prolyl endopeptidase-like
Mouse - 725 17 E4 Prepl prolyl endopeptidase-like
Rat - 638 6q12 Prepl prolyl endopeptidase-like
Database Links
Specialist databases
MEROPS S09.015 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.26

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 8 [PMID: 21692504] Mm Inhibition 5.2 pIC50 1
pIC50 5.2 (IC50 6x10-6 M) [1]
Description: In a substrate free assay.

References

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1. Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF et al.. (2011) A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. J. Am. Chem. Soc.133 (30): 11665-74. [PMID:21692504]

How to cite this page

S9: Prolyl oligopeptidase: prolyl endopeptidase-like. Last modified on 06/08/2015. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2870.