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prolyl endopeptidase like

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Target not currently curated in GtoImmuPdb

Target id: 2870

Nomenclature: prolyl endopeptidase like

Family: S9: Prolyl oligopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 727 2p21 PREPL prolyl endopeptidase like
Mouse - 725 17 E4 Prepl prolyl endopeptidase-like
Rat - 726 6q12 Prepl prolyl endopeptidase-like
Previous and Unofficial Names Click here for help
prolyl endopeptidase-like
Database Links Click here for help
Specialist databases
MEROPS S09.015 (Hs)
Other databases
Alphafold Q4J6C6 (Hs), Q8C167 (Mm), Q5HZA6 (Rn)
BRENDA 3.4.21.26
CATH/Gene3D 3.40.50.1820
ChEMBL Target CHEMBL2189128 (Hs)
Ensembl Gene ENSG00000138078 (Hs), ENSMUSG00000024127 (Mm), ENSRNOG00000007326 (Rn)
Entrez Gene 9581 (Hs), 213760 (Mm), 298771 (Rn)
Human Protein Atlas ENSG00000138078 (Hs)
KEGG Enzyme 3.4.21.26
KEGG Gene hsa:9581 (Hs), mmu:213760 (Mm), rno:298771 (Rn)
OMIM 609557 (Hs)
Pharos Q4J6C6 (Hs)
RefSeq Nucleotide NM_001171603 (Hs), NM_001163622 (Mm), NM_001010951 (Rn)
RefSeq Protein NP_001165074 (Hs), NP_001157094 (Mm), NP_001010951 (Rn)
UniProtKB Q4J6C6 (Hs), Q8C167 (Mm), Q5HZA6 (Rn)
Wikipedia PREPL (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.26

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 8 [PMID: 21692504] Small molecule or natural product Mm Inhibition 5.2 pIC50 1
⤷ pIC50 5.2 (IC50 6x10-6 M) [1]
Description: In a substrate free assay.

References

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1. Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF et al.. (2011) A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. J Am Chem Soc, 133 (30): 11665-74. [PMID:21692504]

How to cite this page

S9: Prolyl oligopeptidase: prolyl endopeptidase like. Last modified on 27/02/2018. Accessed on 01/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2870.