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prolyl endopeptidase like

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Target not currently curated in GtoImmuPdb

Target id: 2870

Nomenclature: prolyl endopeptidase like

Family: S9: Prolyl oligopeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 727 2p21 PREPL prolyl endopeptidase like
Mouse - 725 17 E4 Prepl prolyl endopeptidase-like
Rat - 726 6q12 Prepl prolyl endopeptidase-like
Previous and Unofficial Names Click here for help
prolyl endopeptidase-like
Database Links Click here for help
Specialist databases
MEROPS S09.015 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.26

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 8 [PMID: 21692504] Small molecule or natural product Mm Inhibition 5.2 pIC50 1
pIC50 5.2 (IC50 6x10-6 M) [1]
Description: In a substrate free assay.

References

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1. Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF et al.. (2011) A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. J Am Chem Soc, 133 (30): 11665-74. [PMID:21692504]

How to cite this page

S9: Prolyl oligopeptidase: prolyl endopeptidase like. Last modified on 27/02/2018. Accessed on 19/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2870.