semaphorin 4D (CD100)

Target id: 2883

Nomenclature: semaphorin 4D (CD100)

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     semaphorin 4D (CD100) has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 862 9q22.2 SEMA4D semaphorin 4D
Mouse 1 861 13 B1 Sema4d sema domain
Rat - 862 17p14 Sema4d semaphorin 4D
Gene and Protein Information Comments
A second shorter isoform of human semaphorin-4D with 738 amino acids is reported.
Previous and Unofficial Names
SEMAJ | M-sema-G | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

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Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
VX15/2503 Hs Binding 9.4 pKd 1
pKd 9.4 (Kd 4.5x10-10 M) [1]
Description: Measuring binding to native SEMA4D expressed on human peripheral blood T lymphocytes.
Immunopharmacology Comments
Semaphorin 4D (Sema4D) is an important mediator of the movement and differentiation of multiple cell types, including immune cells [6-7], vascular cells [9], and cells of the nervous system [4]. For example, in the immune system, Sema4D activates B cells and dendritic cells through interaction with CD72 (HGNC ID 1696; P21854) [2-3], and is reported to regulate γδ T cells by binding plexin B2 (PLXNB2; O15031) which contributes to skin wound healing [8]. Experimental evidence using patient-derived cells has identified soluble Sema4D, shed from CD15+ granulocytes, as a causal factor in the promotion of autoreactive antibody secretion by B cells that leads to the development of the autoimmune skin condition bullous pemphigoid [5].
Immuno Process Associations
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
GO Annotation:  Associated to GO processes
GO Processes:  leukocyte aggregation (GO:0070486) IMP
Clinically-Relevant Mutations and Pathophysiology
Disease:  Bullous pemphigoid
Description: Bullous pemphigoid is a potentially fatal, autoimmune subepidermal blistering skin disease.
Orphanet: ORPHA703
References:  5


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1. Fisher TL, Reilly CA, Winter LA, Pandina T, Jonason A, Scrivens M, Balch L, Bussler H, Torno S, Seils J et al.. (2015) Generation and preclinical characterization of an antibody specific for SEMA4D. MAbs, : 1-13 [Epub ahead of print]. [PMID:26431358]

2. Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H. (2003) Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses. Int. Immunol.15 (8): 1027-34. [PMID:12882840]

3. Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T et al.. (2000) Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity13 (5): 621-31. [PMID:11114375]

4. Nkyimbeng-Takwi E, Chapoval SP. (2011) Biology and function of neuroimmune semaphorins 4A and 4D. Immunol. Res.50 (1): 10-21. [PMID:21203905]

5. Shen S, Ke Y, Dang E, Fang H, Chang Y, Zhang J, Zhu Z, Shao S, Qiao P, Zhang T et al.. (2017) Semaphorin 4D from CD15(+) Granulocytes via ADAM10-induced Cleavage Contributes to Antibody Production in Bullous Pemphigoid. J. Invest. Dermatol.,  [Epub ahead of print]. [PMID:29054606]

6. Suzuki K, Kumanogoh A, Kikutani H. (2008) Semaphorins and their receptors in immune cell interactions. Nat. Immunol.9 (1): 17-23. [PMID:18087252]

7. Takamatsu H, Okuno T, Kumanogoh A. (2010) Regulation of immune cell responses by semaphorins and their receptors. Cell. Mol. Immunol.7 (2): 83-8. [PMID:20118971]

8. Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ, Verdino P, Wilson IA, Kumanogoh A, Kikutani H et al.. (2012) The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity37 (2): 314-25. [PMID:22902232]

9. Zhu L, Bergmeier W, Wu J, Jiang H, Stalker TJ, Cieslak M, Fan R, Boumsell L, Kumanogoh A, Kikutani H et al.. (2007) Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc. Natl. Acad. Sci. U.S.A.104 (5): 1621-6. [PMID:17244710]

How to cite this page

CD molecules: semaphorin 4D (CD100). Last modified on 25/10/2017. Accessed on 23/02/2018. IUPHAR/BPS Guide to PHARMACOLOGY,