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semaphorin 4D (CD100)

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2883

Nomenclature: semaphorin 4D (CD100)

Family: CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 862 9q22.2 SEMA4D semaphorin 4D
Mouse 1 861 13 A5 Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Rat - 862 17p14 Sema4d semaphorin 4D
Gene and Protein Information Comments
A second shorter isoform of human semaphorin-4D with 738 amino acids is reported.
Previous and Unofficial Names Click here for help
SEMAJ | M-sema-G | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | sema domain
Database Links Click here for help
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
pepinemab Peptide Primary target of this compound Hs Binding 9.4 pKd 1
pKd 9.4 (Kd 4.5x10-10 M) [1]
Description: Measuring binding to native SEMA4D expressed on human peripheral blood T lymphocytes.
Immunopharmacology Comments
Semaphorin 4D (Sema4D) is an important mediator of the movement and differentiation of multiple cell types, including immune cells [6-7], vascular cells [9], and cells of the nervous system [4]. For example, in the immune system, Sema4D activates B cells and dendritic cells through interaction with CD72 (HGNC ID 1696; P21854) [2-3], and is reported to regulate γδ T cells by binding plexin B2 (PLXNB2; O15031) which contributes to skin wound healing [8]. Experimental evidence using patient-derived cells has identified soluble Sema4D, shed from CD15+ granulocytes, as a causal factor in the promotion of autoreactive antibody secretion by B cells that leads to the development of the autoimmune skin condition bullous pemphigoid [5].
Immuno Process Associations
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0070486 leukocyte aggregation IMP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Bullous pemphigoid
Description: Bullous pemphigoid is a potentially fatal, autoimmune subepidermal blistering skin disease.
Orphanet: ORPHA703
Role: 
References:  5

References

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1. Fisher TL, Reilly CA, Winter LA, Pandina T, Jonason A, Scrivens M, Balch L, Bussler H, Torno S, Seils J et al.. (2016) Generation and preclinical characterization of an antibody specific for SEMA4D. MAbs, 8 (1): 150-62. [PMID:26431358]

2. Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H. (2003) Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses. Int Immunol, 15 (8): 1027-34. [PMID:12882840]

3. Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T et al.. (2000) Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity, 13 (5): 621-31. [PMID:11114375]

4. Nkyimbeng-Takwi E, Chapoval SP. (2011) Biology and function of neuroimmune semaphorins 4A and 4D. Immunol Res, 50 (1): 10-21. [PMID:21203905]

5. Shen S, Ke Y, Dang E, Fang H, Chang Y, Zhang J, Zhu Z, Shao S, Qiao P, Zhang T et al.. (2018) Semaphorin 4D from CD15+ Granulocytes via ADAM10-Induced Cleavage Contributes to Antibody Production in Bullous Pemphigoid. J Invest Dermatol, 138 (3): 588-597. [PMID:29054606]

6. Suzuki K, Kumanogoh A, Kikutani H. (2008) Semaphorins and their receptors in immune cell interactions. Nat Immunol, 9 (1): 17-23. [PMID:18087252]

7. Takamatsu H, Okuno T, Kumanogoh A. (2010) Regulation of immune cell responses by semaphorins and their receptors. Cell Mol Immunol, 7 (2): 83-8. [PMID:20118971]

8. Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ, Verdino P, Wilson IA, Kumanogoh A, Kikutani H et al.. (2012) The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity, 37 (2): 314-25. [PMID:22902232]

9. Zhu L, Bergmeier W, Wu J, Jiang H, Stalker TJ, Cieslak M, Fan R, Boumsell L, Kumanogoh A, Kikutani H et al.. (2007) Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc Natl Acad Sci USA, 104 (5): 1621-6. [PMID:17244710]

How to cite this page

CD molecules: semaphorin 4D (CD100). Last modified on 25/10/2017. Accessed on 31/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2883.