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Bullous pemphigoid

Disease ID:1246
Name:Bullous pemphigoid
Associated with:1 target
Bullous pemphigoid is a potentially fatal, autoimmune subepidermal blistering skin disease.
Database Links
Orphanet: ORPHA703


semaphorin 4D (CD100)
Role:  Sema4D expression is elevated in the serum and blister fluids from patients with bullous pemphigoid. The Sema4D shed from CD15+ granulocytes from these patients drives B cell activation and production of autoreactive antibodies against transmembrane collagen. Destruction of the collagen matrix causes separation of the epidermis and dermis and blister formation.
References:  1


No ligand related data available for Bullous pemphigoid


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1. Shen S, Ke Y, Dang E, Fang H, Chang Y, Zhang J, Zhu Z, Shao S, Qiao P, Zhang T et al.. (2018) Semaphorin 4D from CD15+ Granulocytes via ADAM10-Induced Cleavage Contributes to Antibody Production in Bullous Pemphigoid. J Invest Dermatol, 138 (3): 588-597. [PMID:29054606]