Kynurenine 3-monooxygenase

Target id: 2886

Nomenclature: Kynurenine 3-monooxygenase

Family: kynurenine 3-monooxygenase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Kynurenine 3-monooxygenase has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 486 1q42-q44 KMO kynurenine 3-monooxygenase 1
Mouse 2 479 1 H4 Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Rat 2 478 13q25 Kmo kynurenine 3-monooxygenase
Previous and Unofficial Names
kynurenine 3-hydroxylase | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
Description Reaction Reference
L-kynurenine + NADPH + O2 <=> 3-hydroxy-L-kynurenine + NADP(+) + H2O

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Ligand Sp. Action Affinity Units Reference
GSK180 Hs Inhibition 8.2 pIC50 2
pIC50 8.2 [2]
Description: Biochemical assay using human KMO expressed as a GST-fusion protein in a baculovirus expression system.
Immunopharmacology Comments
GSK120 inhibition of KMO prevents multiple organ failure in rodent models of acute pancreatitis [2] (arises from excessive alcohol consumption)- no current therapy


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1. Alberati-Giani D, Cesura AM, Broger C, Warren WD, Röver S, Malherbe P. (1997) Cloning and functional expression of human kynurenine 3-monooxygenase. FEBS Lett., 410 (2-3): 407-12. [PMID:9237672]

2. Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B et al.. (2016) Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis. Nat. Med., 22 (2): 202-9. [PMID:26752518]

How to cite this page kynurenine 3-monooxygenase: Kynurenine 3-monooxygenase. Last modified on 08/02/2016. Accessed on 23/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY,