arginine demethylase and lysine hydroxylase

Target id: 2892

Nomenclature: arginine demethylase and lysine hydroxylase

Family: 1.14.11.- Histone demethylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for arginine demethylase and lysine hydroxylase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 403 17q25 JMJD6 arginine demethylase and lysine hydroxylase
Mouse - 403 11 E2 Jmjd6 jumonji domain containing 6
Rat - 403 10q32.3 Jmjd6 arginine demethylase and lysine hydroxylase
Gene and Protein Information Comments
For the human JMJD6 we show details of protein isoform 2. Isoform 1 is slightly longer with 414 amino acids (with ref seq NP_001074930).
Previous and Unofficial Names
PSR | PtdSerR | phosphatidylserine receptor | bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 | jumonji domain containing 6
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
General Comments
JMJD6 is an iron- and 2-oxoglutarate-dependent dioxygenase. It is the only known histone arginine demethylase in humans. It catalyses the demethylation of H3R2me2, H4R3me2 and H4R3me1 [1].

References

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1. Chang B, Chen Y, Zhao Y, Bruick RK. (2007) JMJD6 is a histone arginine demethylase. Science318 (5849): 444-7. [PMID:17947579]

How to cite this page

1.14.11.- Histone demethylases: arginine demethylase and lysine hydroxylase. Last modified on 31/03/2017. Accessed on 20/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2892.