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jumonji domain containing 6, arginine demethylase and lysine hydroxylase

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Target not currently curated in GtoImmuPdb

Target id: 2892

Nomenclature: jumonji domain containing 6, arginine demethylase and lysine hydroxylase

Family: 1.14.11.- Histone demethylases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 403 17q25.1 JMJD6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Mouse - 403 11 81.49 cM Jmjd6 jumonji domain containing 6
Rat - 403 10q32.2 Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Gene and Protein Information Comments
For the human JMJD6 we show details of protein isoform 2. Isoform 1 is slightly longer with 414 amino acids (with ref seq NP_001074930).
Previous and Unofficial Names Click here for help
bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 | jumonji domain containing 6 | phosphatidylserine receptor | PSR | PtdSerR
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes, IEA only
GO:0043277 apoptotic cell clearance IMP
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GO:0042116 macrophage activation IEA
GO:0043654 recognition of apoptotic cell IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0043654 recognition of apoptotic cell IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0033077 T cell differentiation in thymus IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0048821 erythrocyte development IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0033077 T cell differentiation in thymus IEA
GO:0048821 erythrocyte development IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0033077 T cell differentiation in thymus IEA
GO:0042116 macrophage activation IEA
General Comments
JMJD6 is a dual arginine demethylase and lysyl hydroxylase of histone and nonhistone proteins [2-3]. It is iron- and 2-oxoglutarate-dependent and is the only known histone arginine demethylase in humans. JMJD6 catalyses the demethylation of H3R2me2, H4R3me2 and H4R3me1 [2]. As a histone arginine demethylase JMJD6 upregulates target gene transcription, and is one of the proteins encoded in the chromosome 17q21-ter gain genetic variant found in human neuroblastoma tissues (and which is a negative prognostic indicator) [1]. As a neuroblastoma tumorigenesis factor JMJD6 is a novel therapeutic target for this cancer [4].

References

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1. Bown N, Cotterill S, Lastowska M, O'Neill S, Pearson AD, Plantaz D, Meddeb M, Danglot G, Brinkschmidt C, Christiansen H et al.. (1999) Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma. N Engl J Med, 340 (25): 1954-61. [PMID:10379019]

2. Chang B, Chen Y, Zhao Y, Bruick RK. (2007) JMJD6 is a histone arginine demethylase. Science, 318 (5849): 444-7. [PMID:17947579]

3. Webby CJ, Wolf A, Gromak N, Dreger M, Kramer H, Kessler B, Nielsen ML, Schmitz C, Butler DS, Yates 3rd JR et al.. (2009) Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science, 325 (5936): 90-3. [PMID:19574390]

4. Wong M, Sun Y, Xi Z, Milazzo G, Poulos RC, Bartenhagen C, Bell JL, Mayoh C, Ho N, Tee AE et al.. (2019) JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma. Nat Commun, 10 (1): 3319. DOI: 10.1038/s41467-019-11132-w [PMID:31346162]

How to cite this page

1.14.11.- Histone demethylases: jumonji domain containing 6, arginine demethylase and lysine hydroxylase. Last modified on 26/07/2019. Accessed on 25/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2892.