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target has curated data in GtoImmuPdb
Target id: 2911
Nomenclature: repulsive guidance molecule BMP co-receptor a
Family: Repulsive guidance molecules
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 450 | 15q26.1 | RGMA | repulsive guidance molecule BMP co-receptor a | |
| Mouse | - | 454 | 7 D1 | Rgma | repulsive guidance molecule family member A | 7 |
| Rat | - | 449 | 1q31 | Rgma | repulsive guidance molecule BMP co-receptor a | |
| Gene and Protein Information Comments | ||||||
| Multiple transcript variants are reported in human, as the result of alternate splicing. We show the longest transcript in the table. | ||||||
| Previous and Unofficial Names |
| repulsive guidance molecule family member a | repulsive guidance molecule family member A |
| Database Links |
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| Alphafold | Q96B86 (Hs), Q6PCX7 (Mm) |
| ChEMBL Target | CHEMBL4630886 (Hs) |
| Ensembl Gene | ENSG00000182175 (Hs), ENSMUSG00000070509 (Mm), ENSRNOG00000012874 (Rn) |
| Entrez Gene | 56963 (Hs), 244058 (Mm), 308739 (Rn) |
| Human Protein Atlas | ENSG00000182175 (Hs) |
| KEGG Gene | hsa:56963 (Hs), mmu:244058 (Mm), rno:308739 (Rn) |
| OMIM | 607362 (Hs) |
| Pharos | Q96B86 (Hs) |
| RefSeq Nucleotide | NM_001166283 (Hs), NM_177740 (Mm), NM_001107524 (Rn) |
| RefSeq Protein | NP_001159755 (Hs), NP_808408 (Mm), NP_001100994 (Rn) |
| UniProtKB | Q96B86 (Hs), Q6PCX7 (Mm) |
| Wikipedia | RGMA (Hs) |
Download all structure-activity data for this target as a CSV file 
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| Immunopharmacology Comments |
| RGMA has been validated as a novel target for pharmacological intervention in neurodegenerative and neuroinflammatory diseases such as multiple sclerosis (MS), as well as for spinal cord injury [3]. Inhibition of RGMA is expected to promote regeneration and neuroprotection in MS [1], acting to concurrently block autoimmune demyelination and axon injury. A clinical candidate monoclonal anti-RGMA antibody, elezanumab (ABT-555), is in Phase 1 development for MS. |
| Physiological Functions
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| Clinically-Relevant Mutations and Pathophysiology
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| Biologically Significant Variants
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| General Comments |
| RGMA is a member of a family of related proteins with functions in the developing and adult nervous systems. Structurally, RGMA is a glycosylphosphatidylinositol-anchored glycoprotein that can also be detected as a soluble form. It inhibits neurite growth [8] which can result in axon and neuron degeneration. The neuronal receptor for RGMA is neogenin (NEO1; Q92859), an immunoglobulin family membrane protein. |
1. Demicheva E, Cui YF, Bardwell P, Barghorn S, Kron M, Meyer AH, Schmidt M, Gerlach B, Leddy M, Barlow E et al.. (2015) Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis. Cell Rep, 10 (11): 1887-98. [PMID:25801027]
2. Hata K, Fujitani M, Yasuda Y, Doya H, Saito T, Yamagishi S, Mueller BK, Yamashita T. (2006) RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J Cell Biol, 173 (1): 47-58. [PMID:16585268]
3. Kubo T, Tokita S, Yamashita T. (2012) Repulsive guidance molecule-a and demyelination: implications for multiple sclerosis. J Neuroimmune Pharmacol, 7 (3): 524-8. [PMID:22183806]
4. Kyoto A, Hata K, Yamashita T. (2007) Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury. Brain Res, 1186: 74-86. [PMID:17996222]
5. Mueller B, Huang L, Bardwell PD, Kutsova Y, Memmot J. (2013) Composition and method for diagnosis and treatment of diseases associated with neurite degeneration. Patent number: WO2013112922 A1. Assignee: AbbVie Deutschland GmbH & Co. KG, Abbvie Inc.. Priority date: 27/01/2012. Publication date: 01/08/2013.
6. Nohra R, Beyeen AD, Guo JP, Khademi M, Sundqvist E, Hedreul MT, Sellebjerg F, Smestad C, Oturai AB, Harbo HF et al.. (2010) RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Genes Immun, 11 (4): 279-93. [PMID:20072140]
7. Schmidtmer J, Engelkamp D. (2004) Isolation and expression pattern of three mouse homologues of chick Rgm. Gene Expr Patterns, 4 (1): 105-10. [PMID:14678836]
8. Tassew NG, Charish J, Seidah NG, Monnier PP. (2012) SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth. Dev Cell, 22 (2): 391-402. [PMID:22340500]
Repulsive guidance molecules: repulsive guidance molecule BMP co-receptor a. Last modified on 27/02/2018. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2911.
