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repulsive guidance molecule BMP co-receptor a

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2911

Nomenclature: repulsive guidance molecule BMP co-receptor a

Family: Repulsive guidance molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 450 15q26.1 RGMA repulsive guidance molecule BMP co-receptor a
Mouse - 454 7 D1 Rgma repulsive guidance molecule family member A 7
Rat - 449 1q31 Rgma repulsive guidance molecule BMP co-receptor a
Gene and Protein Information Comments
Multiple transcript variants are reported in human, as the result of alternate splicing. We show the longest transcript in the table.
Previous and Unofficial Names Click here for help
repulsive guidance molecule family member a | repulsive guidance molecule family member A
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
elezanumab Peptide Primary target of this compound Immunopharmacology Ligand Hs Binding - - 5
Immunopharmacology Comments
RGMA has been validated as a novel target for pharmacological intervention in neurodegenerative and neuroinflammatory diseases such as multiple sclerosis (MS), as well as for spinal cord injury [3]. Inhibition of RGMA is expected to promote regeneration and neuroprotection in MS [1], acting to concurrently block autoimmune demyelination and axon injury. A clinical candidate monoclonal anti-RGMA antibody, elezanumab (ABT-555), is in Phase 1 development for MS.
Physiological Functions Click here for help
Inhibits neuronal regeneration and functional recovery in rat spinal cord injury model.
Species:  Rat
References:  2,4
Causes CNS demyelination via enhanced CD4(+) T cell activation in mouse experimental autoimmune encephalomyelitis (EAE), EAE being a mouse model of MS.
Species:  Mouse
References:  3
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Multiple sclerosis
Disease Ontology: DOID:2377
OMIM: 126200
Orphanet: ORPHA802
References:  6
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Description:  An RGMA SNP associated with MS in male subjects
SNP accession: 
References:  6
General Comments
RGMA is a member of a family of related proteins with functions in the developing and adult nervous systems. Structurally, RGMA is a glycosylphosphatidylinositol-anchored glycoprotein that can also be detected as a soluble form. It inhibits neurite growth [8] which can result in axon and neuron degeneration. The neuronal receptor for RGMA is neogenin (NEO1; Q92859), an immunoglobulin family membrane protein.


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1. Demicheva E, Cui YF, Bardwell P, Barghorn S, Kron M, Meyer AH, Schmidt M, Gerlach B, Leddy M, Barlow E et al.. (2015) Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis. Cell Rep, 10 (11): 1887-98. [PMID:25801027]

2. Hata K, Fujitani M, Yasuda Y, Doya H, Saito T, Yamagishi S, Mueller BK, Yamashita T. (2006) RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J Cell Biol, 173 (1): 47-58. [PMID:16585268]

3. Kubo T, Tokita S, Yamashita T. (2012) Repulsive guidance molecule-a and demyelination: implications for multiple sclerosis. J Neuroimmune Pharmacol, 7 (3): 524-8. [PMID:22183806]

4. Kyoto A, Hata K, Yamashita T. (2007) Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury. Brain Res, 1186: 74-86. [PMID:17996222]

5. Mueller B, Huang L, Bardwell PD, Kutsova Y, Memmot J. (2013) Composition and method for diagnosis and treatment of diseases associated with neurite degeneration. Patent number: WO2013112922 A1. Assignee: AbbVie Deutschland GmbH & Co. KG, Abbvie Inc.. Priority date: 27/01/2012. Publication date: 01/08/2013.

6. Nohra R, Beyeen AD, Guo JP, Khademi M, Sundqvist E, Hedreul MT, Sellebjerg F, Smestad C, Oturai AB, Harbo HF et al.. (2010) RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Genes Immun, 11 (4): 279-93. [PMID:20072140]

7. Schmidtmer J, Engelkamp D. (2004) Isolation and expression pattern of three mouse homologues of chick Rgm. Gene Expr Patterns, 4 (1): 105-10. [PMID:14678836]

8. Tassew NG, Charish J, Seidah NG, Monnier PP. (2012) SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth. Dev Cell, 22 (2): 391-402. [PMID:22340500]

How to cite this page

Repulsive guidance molecules: repulsive guidance molecule BMP co-receptor a. Last modified on 27/02/2018. Accessed on 14/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,