interferon gamma inducible protein 16

Target id: 2924

Nomenclature: interferon gamma inducible protein 16

Abbreviated Name: IFI16

Family: Absent in melanoma (AIM)-like receptors (ALRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     interferon gamma inducible protein 16 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 729 1q23.1 IFI16 interferon gamma inducible protein 16
Gene and Protein Information Comments
A second variant of the human gene (NM_005531) is reported to code isoform 2 (NP_005522) [1-2].
Previous and Unofficial Names
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Immunopharmacology Comments
IFI16 is a sensor for cytosolic DNA which induces type I interferon production via activation of the IRF3/NFκB pathway.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes
GO:0002218 activation of innate immune response IDA
GO:0045824 negative regulation of innate immune response IDA
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GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002218 activation of innate immune response IDA
GO:0045824 negative regulation of innate immune response IDA
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes
GO:0030097 hemopoiesis NAS
GO:0030099 myeloid cell differentiation NAS
GO:0030224 monocyte differentiation IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0001819 positive regulation of cytokine production TAS
GO:0032481 positive regulation of type I interferon production TAS
GO:0032731 positive regulation of interleukin-1 beta production IDA
General Comments
IFI16 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995) [3]. The mouse has 12 IFI16 homologs but none shows 1:1 orthology with the human gene.


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1. Amrani Y, Tliba O, Choubey D, Huang CD, Krymskaya VP, Eszterhas A, Lazaar AL, Panettieri Jr RA. (2003) IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway. Am. J. Physiol. Lung Cell Mol. Physiol.284 (6): L1063-71. [PMID:12588705]

2. Johnstone RW, Kershaw MH, Trapani JA. (1998) Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. Biochemistry37 (34): 11924-31. [PMID:9718316]

3. Schattgen SA, Fitzgerald KA. (2011) The PYHIN protein family as mediators of host defenses. Immunol. Rev.243 (1): 109-18. [PMID:21884171]

How to cite this page

Absent in melanoma (AIM)-like receptors (ALRs): interferon gamma inducible protein 16. Last modified on 03/03/2017. Accessed on 21/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,