SIRPA (CD172a)

Target id: 2942

Nomenclature: SIRPA (CD172a)

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     SIRPA (CD172a) has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 504 20p13 SIRPA signal regulatory protein alpha
Mouse 1 513 2 F1; 2 63.19 cM Sirpa signal-regulatory protein alpha
Rat 1 509 3q36 Sirpa signal-regulatory protein alpha
Gene and Protein Information Comments
Details are provided for the shorter protein isoform (isoform 1) encoded by the human gene. Isofom 2 is the longer protein at 508 amino acids (see NP_001317657). For the mouse, we show isoform 3 peptide details.
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
Pharmacological agents which block the SIRPα/CD47 antiphagocytic axis are being investigated as potential immuno-oncology therapeutics which would act to promote immunosurveillance and increase phagocytosis of cancer cells by tumour associated macrophages (TAMs). Specifically, the anti-SIPRα monoclonal antibody OSE-172 (Effi-DEM) is in early stage development (OSE IMMUNOTherapeutics), and proof of concept has been demonstrated in in vivo models. Preclinical testing suggests that the therapeutic effect of OSE-172 is observed in both monotherapy or when combined with other checkpoint inhibitors, or with immune system stimulators. Anti-CD47 antibodies are also in early stage development, as reported by Gholamin et al. (2017) [1].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  neutrophil degranulation (GO:0043312) TAS
leukocyte migration (GO:0050900) TAS
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  leukocyte migration (GO:0050900) TAS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  neutrophil degranulation (GO:0043312) TAS
References: 
General Comments
The SIPRα protein binding interaction with CD47 produces an antiphagocytic signal, that is often termed a 'don't eat me' signal.

References

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1. Gholamin S, Mitra SS, Feroze AH, Liu J, Kahn SA, Zhang M, Esparza R, Richard C, Ramaswamy V, Remke M et al.. (2017) Disrupting the CD47-SIRPĪ± anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors. Sci Transl Med9 (381). [PMID:28298418]

How to cite this page

CD molecules: SIRPA (CD172a). Last modified on 31/07/2017. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2942.