butyrophilin like 3 | Butyrophilin and butyrophilin-like proteins | IUPHAR/BPS Guide to PHARMACOLOGY

butyrophilin like 3

Target id: 2944

Nomenclature: butyrophilin like 3

Family: Butyrophilin and butyrophilin-like proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     butyrophilin like 3 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 466 5q35.3 BTNL3 butyrophilin like 3 3
Previous and Unofficial Names
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Immunopharmacology Comments
BTNL3 and BTNL8 are two proteins expressed on the surface of human gut epithelial cells that are involved in shaping the constitution of gut resident dendritic γδ T cells [1]. γδ T cells in epithelial surfaces play a role in immunosurveillance and hence barrier integrity. Organ-specific expression of butyrophilin and butyrophilin-like proteins appears to be a conserved mechanism utilised by epithelia to shape local T cell compartments. Altered expression of BTNL genes has been associated with intestinal inflammation and colon cancer [2].


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1. Di Marco Barros R, Roberts NA, Dart RJ, Vantourout P, Jandke A, Nussbaumer O, Deban L, Cipolat S, Hart R, Iannitto ML et al.. (2016) Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments. Cell, 167 (1): 203-218.e17. [PMID:27641500]

2. Lebrero-Fernández C, Wenzel UA, Akeus P, Wang Y, Strid H, Simrén M, Gustavsson B, Börjesson LG, Cardell SL, Öhman L et al.. (2016) Altered expression of Butyrophilin (BTN) and BTN-like (BTNL) genes in intestinal inflammation and colon cancer. Immun Inflamm Dis, 4 (2): 191-200. [PMID:27957327]

3. Shibui A, Tsunoda T, Seki N, Suzuki Y, Sugano S, Sugane K. (1999) Cloning, expression analysis, and chromosomal localization of a novel butyrophilin-like receptor. J. Hum. Genet., 44 (4): 249-52. [PMID:10429365]

How to cite this page

Butyrophilin and butyrophilin-like proteins: butyrophilin like 3. Last modified on 27/07/2017. Accessed on 25/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2944.