Piezo1 | Piezo channels | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

Piezo1

Target id: 2945

Nomenclature: Piezo1

Family: Piezo channels

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Piezo1 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2521 16q24.3 PIEZO1 piezo type mechanosensitive ion channel component 1
Mouse - 2547 8 E1 Piezo1 piezo-type mechanosensitive ion channel component 1
Rat - 2535 19q12 Piezo1 piezo-type mechanosensitive ion channel component 1
Gene and Protein Information Comments
Piezo proteins have between 24 and 36 predicted transmembrane (TM) domains, although a much lower number (14) of TM domains are resolved in the Piezo1 structure than initially predicted through topology software [1].
Previous and Unofficial Names
FAM38A | family with sequence similarity 38, member A | DHS | Mib | LMPH3
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Cryo-EM study of the mammalian mechanosensitive Piezo1 channel
PDB Id:  3JAC
Resolution:  4.8Å
Species:  Mouse
References:  2
Immunopharmacology Comments
Work by Liu et al. (2018) shows that Piezo1 is involved in immune regulation [3]. Piezo1-signalling appears to cause a rearrangement of the actin scaffold, that connects this mechanosensor's function to optimal T cell receptor signaling and T cell activation.
Cell Type Associations
Immuno Cell Type:  T cells
Comment:  Piezo1 mechanosensors are involved in the optimisation of human T cell activation and in T cell proliferation.
References:  3

References

Show »

1. Coste B, Murthy SE, Mathur J, Schmidt M, Mechioukhi Y, Delmas P, Patapoutian A. (2015) Piezo1 ion channel pore properties are dictated by C-terminal region. Nat Commun, 6: 7223. [PMID:26008989]

2. Ge J, Li W, Zhao Q, Li N, Chen M, Zhi P, Li R, Gao N, Xiao B, Yang M. (2015) Architecture of the mammalian mechanosensitive Piezo1 channel. Nature, 527 (7576): 64-9. [PMID:26390154]

3. Liu CSC, Raychaudhuri D, Paul B, Chakrabarty Y, Ghosh AR, Rahaman O, Talukdar A, Ganguly D. (2018) Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation. J. Immunol., 200 (4): 1255-1260. [PMID:29330322]

How to cite this page

Piezo channels: Piezo1. Last modified on 13/09/2018. Accessed on 17/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2945.