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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 36 | 2521 | 16q24.3 | PIEZO1 | piezo type mechanosensitive ion channel component 1 (Er blood group) | |
| Mouse | 35 | 2547 | 8 E1 | Piezo1 | piezo-type mechanosensitive ion channel component 1 | |
| Rat | 35 | 2535 | 19q12 | Piezo1 | piezo-type mechanosensitive ion channel component 1 | |
| Gene and Protein Information Comments | ||||||
| Piezo proteins have between 24 and 36 predicted transmembrane (TM) domains, although a much lower number (14) of TM domains are resolved in the Piezo1 structure than initially predicted through topology software [1]. | ||||||
| Previous and Unofficial Names |
| piezo type mechanosensitive ion channel component 1 | FAM38A | family with sequence similarity 38, member A | DHS | Mib | LMPH3 |
| Database Links |
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| Alphafold | Q92508 (Hs), E2JF22 (Mm), Q0KL00 (Rn) |
| Ensembl Gene | ENSG00000103335 (Hs), ENSMUSG00000014444 (Mm), ENSRNOG00000056786 (Rn) |
| Entrez Gene | 9780 (Hs), 234839 (Mm), 361430 (Rn) |
| Human Protein Atlas | ENSG00000103335 (Hs) |
| KEGG Gene | hsa:9780 (Hs), mmu:234839 (Mm), rno:361430 (Rn) |
| OMIM | 611184 (Hs) |
| Orphanet | ORPHA303176 (Hs) |
| Pharos | Q92508 (Hs) |
| RefSeq Nucleotide | NM_001142864 (Hs), NM_001037298 (Mm), NM_001077200 (Rn) |
| RefSeq Protein | NP_001136336 (Hs), NP_001032375 (Mm), NP_001070668 (Rn) |
| UniProtKB | Q92508 (Hs), E2JF22 (Mm), Q0KL00 (Rn) |
| Wikipedia | PIEZO1 (Hs) |
| Selected 3D Structures |
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| Functional Characteristics |
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| Mechano-activated | |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific activator tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| Work by Liu et al. (2018) shows that Piezo1 is involved in immune regulation [4]. Piezo1 signalling appears to cause a rearrangement of the actin scaffold, that connects this mechanosensor's function to optimal T cell receptor signalling and T cell activation. Knock out of Piezo1 channels in the innate immune cells of mice has shown that mechanosensation of force by Piezo1 in the lung is an essential component of innate immune system-mediated inflammatory reponses [5]. |
| Cell Type Associations | ||||||
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1. Coste B, Murthy SE, Mathur J, Schmidt M, Mechioukhi Y, Delmas P, Patapoutian A. (2015) Piezo1 ion channel pore properties are dictated by C-terminal region. Nat Commun, 6: 7223. [PMID:26008989]
2. Evans EL, Cuthbertson K, Endesh N, Rode B, Blythe NM, Hyman AJ, Hall SJ, Gaunt HJ, Ludlow MJ, Foster R et al.. (2018) Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol, 175 (10): 1744-1759. [PMID:29498036]
3. Ge J, Li W, Zhao Q, Li N, Chen M, Zhi P, Li R, Gao N, Xiao B, Yang M. (2015) Architecture of the mammalian mechanosensitive Piezo1 channel. Nature, 527 (7576): 64-9. [PMID:26390154]
4. Liu CSC, Raychaudhuri D, Paul B, Chakrabarty Y, Ghosh AR, Rahaman O, Talukdar A, Ganguly D. (2018) Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation. J Immunol, 200 (4): 1255-1260. [PMID:29330322]
5. Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG et al.. (2019) Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature, 573 (7772): 69-74. [PMID:31435009]
6. Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH et al.. (2015) Chemical activation of the mechanotransduction channel Piezo1. Elife, 4. [PMID:26001275]
7. Wang Y, Chi S, Guo H, Li G, Wang L, Zhao Q, Rao Y, Zu L, He W, Xiao B. (2018) A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun, 9 (1): 1300. [PMID:29610524]
Piezo channels: Piezo1. Last modified on 26/08/2019. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2945.
target has curated data in GtoImmuPdb
