Hepatitis C virus genome polyprotein

Target id: 2952

Nomenclature: Hepatitis C virus genome polyprotein

Systematic Nomenclature: Hepatitis C virus genome polyprotein

Family: Anti-infective targets

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Hepatitis C virus genome polyprotein in GtoImmuPdb

Database Links
UniProtKB

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
simeprevir HCV Inhibition 9.4 pKi 1
pKi 9.4 (Ki 3.6x10-10 M) [1]
General Comments
This polyprotein precursor is proteolytically processed inside the host cell to spawn a number of separate activities (see GO terms in UniProt entry) , including enzymes that are important for viral replication. Several of these are being persued as different anti-viral drug targets.

References

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1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wähling H, Wickström K et al.. (2008) Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg. Med. Chem. Lett.18 (17): 4853-8. [PMID:18678486]

How to cite this page

Anti-infective targets: Hepatitis C virus genome polyprotein. Last modified on 18/08/2017. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2952.