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Hepatitis C virus genome polyprotein

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Target not currently curated in GtoImmuPdb

Target id: 2952

Nomenclature: Hepatitis C virus genome polyprotein

Systematic Nomenclature: Hepatitis C virus genome polyprotein

Family: Other viral proteins

Contents:

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UniProtKB Q6GYR8 (HCV)

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Inhibitors
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Ligand Sp. Action Value Parameter Reference
simeprevir Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure HCV Inhibition 9.4 pKi 1
⤷ pKi 9.4 (Ki 3.6x10-10 M) [1]
General Comments
This polyprotein precursor is proteolytically processed inside the host cell to spawn a number of separate activities (see GO terms in UniProt entry) , including enzymes that are important for viral replication. Several of these are being persued as different anti-viral drug targets.

References

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1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wähling H, Wickström K et al.. (2008) Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett, 18 (17): 4853-8. [PMID:18678486]

How to cite this page

Other viral proteins: Hepatitis C virus genome polyprotein. Last modified on 31/03/2020. Accessed on 03/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2952.