Plasmodium falciparum cGMP-dependent protein kinase | Antimalarial targets | IUPHAR/BPS Guide to PHARMACOLOGY

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Plasmodium falciparum cGMP-dependent protein kinase

Target not currently curated in GtoImmuPdb

  Target has curated data in GtoMPdb

Target id: 3013

Nomenclature: Plasmodium falciparum cGMP-dependent protein kinase

Abbreviated Name: PfPKG

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 853 PKG cGMP-dependent protein kinase
Database Links
Malaria Pharmacology Comments
The Plasmodium cGMP-dependent protein kinase (PfPKG) is an attractive target for next generation antimalarials as it has been implicated in multiple cellular activities at various stages of the parasite lifecycle [1]. A medicinal chemistry programme has identified an imidazopyridine series that demonstrates promising activity and may warrant further development [2].


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1. Alam MM, Solyakov L, Bottrill AR, Flueck C, Siddiqui FA, Singh S, Mistry S, Viskaduraki M, Lee K, Hopp CS et al.. (2015) Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion. Nat Commun, 6: 7285. [PMID:26149123]

2. Baker DA, Stewart LB, Large JM, Bowyer PW, Ansell KH, Jiménez-Díaz MB, El Bakkouri M, Birchall K, Dechering KJ, Bouloc NS et al.. (2017) A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission. Nat Commun, 8 (1): 430. [PMID:28874661]

How to cite this page

Antimalarial targets: Plasmodium falciparum cGMP-dependent protein kinase. Last modified on 29/01/2019. Accessed on 17/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY,