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carnitine palmitoyltransferase 1B

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Target not currently curated in GtoImmuPdb

Target id: 3250

Nomenclature: carnitine palmitoyltransferase 1B

Family: Carnitine palmitoyltransferases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 772 22q13.33 CPT1B carnitine palmitoyltransferase 1B
Mouse 2 772 15 44.89 cM Cpt1b carnitine palmitoyltransferase 1b, muscle
Rat 2 772 7q34 Cpt1b carnitine palmitoyltransferase 1B
Previous and Unofficial Names Click here for help
carnitine O-palmitoyltransferase 1B | M-CPT-1 | Carnitine O-palmitoyltransferase 1, muscle isoform
Database Links Click here for help
Alphafold Q92523 (Hs), O35287 (Mm), CPT1B_RAT (Rn)
BRENDA 3.2.1.21
ChEMBL Target CHEMBL2216739 (Hs), CHEMBL3216 (Rn)
Ensembl Gene ENSG00000205560 (Hs), ENSMUSG00000078937 (Mm), ENSRNOG00000010438 (Rn)
Entrez Gene 1375 (Hs), 12895 (Mm), 25756 (Rn)
Human Protein Atlas ENSG00000205560 (Hs)
KEGG Enzyme 3.2.1.21
KEGG Gene hsa:1375 (Hs), mmu:12895 (Mm), rno:25756 (Rn)
OMIM 601987 (Hs)
Pharos Q92523 (Hs)
UniProtKB Q92523 (Hs), O35287 (Mm), CPT1B_RAT (Rn)
Wikipedia CPT1B (Hs)
Enzyme Reaction Click here for help
EC Number: 3.2.1.21

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
teglicar Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Inhibition 4.4 pIC50 1
⤷ pIC50 4.4 (IC50 4.34x10-5 M) [1]
Description: Measuring the incorporation of [14C]-palmitoyl residue on carnitine in intact fresh heart mithocondria from male Sprague-Dawley rats

References

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1. Giannessi F, Pessotto P, Tassoni E, Chiodi P, Conti R, De Angelis F, Dell'Uomo N, Catini R, Deias R, Tinti MO et al.. (2003) Discovery of a Long-Chain Carbamoyl Aminocarnitine Derivative, a Reversible Carnitine Palmitoyltransferase Inhibitor with Antiketotic and Antidiabetic Activity. Jourmal of Medicinal Chemistry, 46 (2): 303–309. DOI: 10.1021/jm020979u

How to cite this page

Carnitine palmitoyltransferases: carnitine palmitoyltransferase 1B. Last modified on 06/02/2024. Accessed on 28/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3250.