PAR3 | Proteinase-activated receptors | IUPHAR/BPS Guide to PHARMACOLOGY

PAR3

Target id: 349

Nomenclature: PAR3

Family: Proteinase-activated receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for PAR3 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 374 5q13 F2RL2 coagulation factor II thrombin receptor like 2
Mouse 7 369 13 D1 F2rl2 coagulation factor II (thrombin) receptor-like 2
Rat 7 368 2q12 F2rl2 coagulation factor II (thrombin) receptor-like 2
Previous and Unofficial Names
coagulation factor II receptor-like 2 | protease-activated receptor 3 | thrombin receptor-like 2 | coagulation factor II (thrombin) receptor-like 2
Database Links
Specialist databases
GPCRDB par3_human (Hs), par3_mouse (Mm), par3_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
thrombin {Sp: Human} , thrombin {Sp: Mouse} , thrombin {Sp: Rat}
Agonist proteases (Human)
thrombin (F2, P00734)
Expression Datasets

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Physiological Consequences of Altering Gene Expression
PAR3 is required for neuronal protective effects of activated protein C (APC). PAR3 knockout mice do not display neuronal protective effects of APC
Species:  Mouse
Tissue:  CNS
Technique:  Gene knockouts
References:  2
PAR3 knockout mice are protected against thrombosis. PAR3 knockout mice are protected against ferric chloride-induced thrombosis and thromboplastin-induced pulmonary embolism, with decreased platelet activation responses to thrombin.
Species:  Mouse
Tissue:  Platelets
Technique:  Gene knockouts
References:  1,3
Phenotypes, Alleles and Disease Models Mouse data from MGI

Show »

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh
involves: 129S4/SvJae * C57BL/6
MGI:1298208  MP:0005464 abnormal platelet physiology PMID: 9716134 
F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh
involves: 129S4/SvJae * C57BL/6
MGI:1298208  MP:0005606 increased bleeding time PMID: 12384423 
F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh
involves: 129S4/SvJae * C57BL/6
MGI:1298208  MP:0005048 thrombosis PMID: 12384423 

References

Show »

1. Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR. (2010) Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proc. Natl. Acad. Sci. U.S.A., 107 (43): 18605-10. [PMID:20930120]

2. Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fern├índez JA, Griffin JH, Zlokovic BV. (2004) Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron, 41 (4): 563-72. [PMID:14980205]

3. Weiss EJ, Hamilton JR, Lease KE, Coughlin SR. (2002) Protection against thrombosis in mice lacking PAR3. Blood, 100 (9): 3240-4. [PMID:12384423]

Contributors

Show »

How to cite this page

Nigel Bunnett, Kathryn DeFea, Justin Hamilton, Morley D. Hollenberg, Rithwik Ramachandran, JoAnn Trejo.
Proteinase-activated receptors: PAR3. Last modified on 27/01/2015. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=349.