TRPV3 | Transient Receptor Potential channels | IUPHAR/BPS Guide to PHARMACOLOGY

TRPV3

Target id: 509

Nomenclature: TRPV3

Family: Transient Receptor Potential channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for TRPV3 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 790 17p13.3 TRPV3 transient receptor potential cation channel subfamily V member 3 23,28
Mouse 6 1 791 11 B4 Trpv3 transient receptor potential cation channel, subfamily V, member 3 21
Rat 6 1 791 10q24 Trpv3 transient receptor potential cation channel, subfamily V, member 3
Previous and Unofficial Names
VRL3 | OLMS | transient receptor potential cation channel, subfamily V, member 3 | transient receptor potential cation channel
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
TRPV1 23
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
calmodulin 18,22,26
epidermal growth factor receptor 6
AKAP79 (AKAP-5) 29
Functional Characteristics
γ = 197 pS at = +40 to +80 mV, 48 pS at negative potentials; conducts mono- and di-valent cations; outward rectification; potentiated by arachidonic acid
Ion Selectivity and Conductance
Species:  Human
Rank order:  Ca2+ > Cs+ [172.0 pS] = K+ = Na+
References:  28
Ion Selectivity and Conductance Comments
The reported conductance (pS) for mouse TRPV3 is 201 at negative potentials and 147 at positive potentials [9].
TRPV3 unitary current amplitude is temperature dependent and increases with increasing temperature [9].
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  - - Primary human keratinocytes, HEK-293 cells transfected with a human TRPV3 channel Human
Inactivation  - -
Comments  Gq-coupled receptor activation shifts TRPV3 voltage dependence of activation to less positive potentials in both primary human keratinocytes and transfected HEK-293 cells [12].
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  80.7 – 144.0 - 7,26 HEK 293 cells transfected with the TRPV3 channel. Mouse
Inactivation  - -
Comments  Activation by two identical consecutive heat stimuli shifts V0.5 to less positive potential [7].
Other chemical activators (Human)
NO-mediated cysteine S-nitrosylation
Physical activators (Human)
depolarization (V½ ~ +80 mV, reduced to more negative values following heat stimuli), heat (23°C - 39°C, temperature threshold reduces with repeated heat challenge)

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
vanillin Mm Activation - - 1x10-2 -80.0 – 80.0 27
Conc range: 1x10-2 M [27]
Holding voltage: -80.0 – 80.0 mV
Description: Two-electrode voltage-clamp
eugenol Mm Full agonist - - 3x10-3 -80.0 – 80.0 27
Conc range: 3x10-3 M [27]
Holding voltage: -80.0 – 80.0 mV
Description: Patch clamp electrophysiology
cinnamaldehyde Mm Agonist - - 5x10-4 - 5x10-3 -80.0 – 80.0 17
Conc range: 5x10-4 - 5x10-3 M [17]
Holding voltage: -80.0 – 80.0 mV
camphor Mm Full agonist - - 1x10-3 - 2x10-3 -60.0 19
Conc range: 1x10-3 - 2x10-3 M [19]
Holding voltage: -60.0 mV
Description: Patch clamp electrophysiology
carvacrol Mm Full agonist - - 5x10-4 -80.0 – 80.0 27
Conc range: 5x10-4 M [27]
Holding voltage: -80.0 – 80.0 mV
Description: Patch clamp electrophysiology
thymol Mm Full agonist - - 5x10-4 -80.0 – 80.0 27
Conc range: 5x10-4 M [27]
Holding voltage: -80.0 – 80.0 mV
Description: Patch clamp electrophysiology
citral Mm Activation 3.0 pKd - -100.0 – 100.0 24
pKd 3.0 (Kd 9.26x10-4 M) [24]
Holding voltage: -100.0 – 100.0 mV
Description: Patch clamp electrophysiology
farnesyl diphosphate Mm Activation 6.9 pEC50 - - 2
pEC50 6.9 (EC50 1.3x10-7 M) Specifically activates TRPV3 among the tested TRP channels [2]
Description: Calcium imaging and patch clamp electrophysiology
cannabidiol Rn Activation 5.4 pEC50 - - 11
pEC50 5.4 (EC50 3.7x10-6 M) [11]
Description: Calcium imaging
tetrahydrocannabivarin Rn Activation 5.4 pEC50 - - 11
pEC50 5.4 (EC50 3.8x10-6 M) [11]
Description: Calcium imaging
incensole acetate Mm Activation 4.8 pEC50 - - 20
pEC50 4.8 (EC50 1.6x10-5 M) [20]
Description: Calcium imaging
2-APB Mm Full agonist 4.6 pEC50 - -80.0 – 80.0 9
pEC50 4.6 (EC50 2.51x10-5 M) [9]
Holding voltage: -80.0 – 80.0 mV
Description: Patch clamp electrophysiology
diphenylboronic anhydride Mm Full agonist 4.1 – 4.2 pEC50 - -80.0 – 80.0 7
pEC50 4.1 – 4.2 (EC50 7.94x10-5 – 6.31x10-5 M) [7]
Holding voltage: -80.0 – 80.0 mV
Description: Patch clamp electrophysiology
6-tert-butyl-m-cresol Mm Activation 3.4 pEC50 - - 25
pEC50 3.4 (EC50 3.7x10-4 M) [25]
Description: Two-electrode voltage-clamp
dihydrocarveol Mm Activation 2.6 pEC50 - - 25
pEC50 2.6 (EC50 2.57x10-3 M) [25]
Description: Two-electrode voltage-clamp
carveol Mm Activation 2.5 pEC50 - - 25
pEC50 2.5 (EC50 3.03x10-3 M) [25]
borneol Mm Activation 2.5 pEC50 - - 25
pEC50 2.5 (EC50 3.45x10-3 M) [25]
Description: Two-electrode voltage-clamp
(-)-menthol Mm Activation 1.7 pEC50 - -80.0 – 80.0 17
pEC50 1.7 (EC50 1.995x10-2 M) [17]
Holding voltage: -80.0 – 80.0 mV
Description: Patch clamp electrophysiology and calcium imaging
View species-specific activator tables
Activator Comments
Chemical or thermal activation of TRPV3 evokes biphasic currents [7].
TRPV3 is also activated by innocuous heat [21,23,28].
Other monoterpenes including geraniol, linalool and propofol are reported to activate TRPV3 [25].
Sequentially applied high concentrations of diphenylboronic anhydride inhibit TRPV3 [7].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 74a [PMID: 27077528] Hs Antagonist 6.4 pIC50 13
pIC50 6.4 (IC50 3.8x10-7 M) [13]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
ruthenium red Mm Inhibition - - 1x10-6 -60.0 21
Conc range: 1x10-6 M [21]
Holding voltage: -60.0 mV
Description: Patch clamp electrophysiology
isopentenyl diphosphate Hs Inhibition 6.6 pIC50 - - 3
pIC50 6.6 (IC50 2.39x10-7 M) [3]
Description: Calcium imaging
aspirin-triggered resolvin D1 Hs Inhibition 6.4 pIC50 - - 4
pIC50 6.4 (IC50 3.98x10-7 M) [4]
Description: Calcium imaging
diphenyltetrahydrofuran Mm Antagonist 5.0 – 5.2 pIC50 - -80.0 – 80.0 7
pIC50 5.0 – 5.2 (IC50 1x10-8 – 6x10-9 M) [7]
Holding voltage: -80.0 – 80.0 mV
Description: Patch clamp electrophysiology
View species-specific channel blocker tables
Channel Blocker Comments
The value shown above for diphenyltetrahydrofuran represents action on initial current component [7].
Tissue Distribution
Brain, spinal cord, dorsal root ganglia, skin, testes, stomach, trachea, small intestine, placenta, tongue, hair follicles, pituitary gland and adipose tissue.
Species:  Human
Technique:  In situ hybridisation, RT-PCR, northern blot, immunohistochemistry
References:  23,28
Skin keratinocytes, hair follicles, tongue and nasal epithelium
Species:  Mouse
Technique:  In situ hybridisation, northern blot, immunohistochemistry
References:  21,27
Skin
Species:  Rat
Technique:  Northern blot
References:  21
Functional Assays
Patch clamp (whole-cell and single channel recordings) and calcium imaging.
Species:  Human
Tissue:  CHO-K1 anf HEK-293 cells transfected with a TRPV3 containing vector and human keratinocytes.
Response measured:  Activation by innocuous heat and/or chemical activator
References:  12,23,28
Patch clamp, two-electrode voltage-clamp and calcium imaging.
Species:  Mouse
Tissue:  CHO-K1 and HEK-293 cells transfected with a TRPV3 containing vector, mouse keratinocytes, mouse dorsal root ganglion neurons, 308 keratinocytes, Xenopus oocytes expressing mouse TRPV3.
Response measured:  Activation by innocuous heat, chemical activator and plant-derived substances.
References:  8-9,14,21,24-25,27
Physiological Functions
Thermosensation, hair growth control
Species:  Human
Tissue:  Skin keratinocytes, hair follicles, sensory neurons
References:  5,23,28
Thermosensation (innocuous heat), detection and integration of innocuous and noxious stimuli (acute nociceptive pain), regulation of hair morphogenesis and skin barrier formation.
Species:  Mouse
Tissue:  Skin keratinocytes and sensory neurons.
References:  1,6,15,19,21
Physiological Consequences of Altering Gene Expression
TRPV3 knockout mice show impaired thermosensation, display a wavy hair coat and curly whiskers and have dry and scaly skin.
Species:  Mouse
Tissue: 
Technique:  Gene knockout by homologous recombination (PMID: 15746429 and PMID: 20403327).
References:  6,19
Keratinocyte specific TRPV3 transgenic mice show increased thermal nociception upon pharmacological inhibition of TRPV1.
Species:  Mouse
Tissue:  Skin
Technique:  Overexpression: TRPV3-YFP transgene expression under control of the keratin 14 promoter
References:  15
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Trpv3tm1Apat Trpv3tm1Apat/Trpv3tm1Apat
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MGI:2181407  MP:0000367 abnormal coat/ hair morphology PMID: 15746429 
Tg(KRT14-cre)1Amc|Trpv3tm1.1Clph Tg(KRT14-cre)1Amc/0,Trpv3tm1.1Clph/Trpv3tm1.1Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA * Swiss Webster
MGI:2181407  MGI:2450263  MP:0009594 abnormal corneocyte envelope morphology PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA
MGI:2181407  MP:0009594 abnormal corneocyte envelope morphology PMID: 20403327 
Tg(KRT14-cre)1Amc|Trpv3tm1.1Clph Tg(KRT14-cre)1Amc/0,Trpv3tm1.1Clph/Trpv3tm1.1Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA * Swiss Webster
MGI:2181407  MGI:2450263  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA
MGI:2181407  MP:0001240 abnormal epidermis stratum corneum morphology PMID: 20403327 
Tg(KRT14-cre)1Amc|Trpv3tm1.1Clph Tg(KRT14-cre)1Amc/0,Trpv3tm1.1Clph/Trpv3tm1.1Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA * Swiss Webster
MGI:2181407  MGI:2450263  MP:0000383 abnormal hair follicle orientation PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA
MGI:2181407  MP:0000383 abnormal hair follicle orientation PMID: 20403327 
Trpv3+|Trpv3Nh Trpv3Nh/Trpv3+
DS
MGI:2181407  MP:0002073 abnormal hair growth PMID: 9250484 
Trpv3tm1Apat Trpv3tm1Apat/Trpv3tm1Apat
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MGI:2181407  MP:0003453 abnormal keratinocyte physiology PMID: 15746429 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA
MGI:2181407  MP:0003453 abnormal keratinocyte physiology PMID: 20403327 
Trpv3tm1Apat Trpv3tm1Apat/Trpv3tm1Apat
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MGI:2181407  MP:0003663 abnormal thermosensation PMID: 15746429 
Tg(KRT14-cre)1Amc|Trpv3tm1.1Clph Tg(KRT14-cre)1Amc/0,Trpv3tm1.1Clph/Trpv3tm1.1Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA * Swiss Webster
MGI:2181407  MGI:2450263  MP:0001274 curly vibrissae PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
B6.129S4-Trpv3
MGI:2181407  MP:0001274 curly vibrissae PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA
MGI:2181407  MP:0001274 curly vibrissae PMID: 20403327 
Trpv3+|Trpv3Nh Trpv3Nh/Trpv3+
DS
MGI:2181407  MP:0001194 dermatitis PMID: 9250484 
Tg(KRT14-cre)1Amc|Trpv3tm1.1Clph Tg(KRT14-cre)1Amc/0,Trpv3tm1.1Clph/Trpv3tm1.1Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA * Swiss Webster
MGI:2181407  MGI:2450263  MP:0003853 dry skin PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA
MGI:2181407  MP:0003853 dry skin PMID: 20403327 
Tg(KRT14-cre)1Amc|Trpv3tm1.1Clph Tg(KRT14-cre)1Amc/0,Trpv3tm1.1Clph/Trpv3tm1.1Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA * Swiss Webster
MGI:2181407  MGI:2450263  MP:0003454 erythroderma PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA
MGI:2181407  MP:0003454 erythroderma PMID: 20403327 
Trpv3+|Trpv3Nh Trpv3Nh/Trpv3+
DS
MGI:2181407  MP:0002412 increased susceptibility to bacterial infection PMID: 9250484 
Trpv3tm1Apat Trpv3tm1Apat/Trpv3tm1Apat
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MGI:2181407  MP:0001973 increased thermal nociceptive threshold PMID: 15746429 
Tg(KRT14-cre)1Amc|Trpv3tm1.1Clph Tg(KRT14-cre)1Amc/0,Trpv3tm1.1Clph/Trpv3tm1.1Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA * Swiss Webster
MGI:2181407  MGI:2450263  MP:0001192 scaly skin PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA
MGI:2181407  MP:0001192 scaly skin PMID: 20403327 
Tg(KRT14-cre)1Amc|Trpv3tm1.1Clph Tg(KRT14-cre)1Amc/0,Trpv3tm1.1Clph/Trpv3tm1.1Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA * Swiss Webster
MGI:2181407  MGI:2450263  MP:0000410 waved hair PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
B6.129S4-Trpv3
MGI:2181407  MP:0000410 waved hair PMID: 20403327 
Trpv3tm1.2Clph Trpv3tm1.2Clph/Trpv3tm1.2Clph
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA
MGI:2181407  MP:0000410 waved hair PMID: 20403327 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Palmoplantar keratoderma, mutilating, with periorificial keratotic plaques
Synonyms: Olmsted syndrome
OMIM: 614594
Orphanet: ORPHA659
References:  16
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human G573A 10
Missense Human G573S 16
Missense Human G573C 16
Missense Human W692G 16
Biologically Significant Variants
Type:  Missense mutation
Species:  Mouse
Description:  A spontaneous G573C missense mutation in mice leads to dermatitis and hairlessness
Amino acid change:  G573C
References:  1
Type:  Missense mutation
Species:  Mouse
Description:  A spontaneous G573S missense mutation in mice leads to dermatitis and hairlessness
Amino acid change:  G573S
References:  1

References

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1. Asakawa M, Yoshioka T, Matsutani T, Hikita I, Suzuki M, Oshima I, Tsukahara K, Arimura A, Horikawa T, Hirasawa T, Sakata T. (2006) Association of a mutation in TRPV3 with defective hair growth in rodents. J. Invest. Dermatol., 126 (12): 2664-72. [PMID:16858425]

2. Bang S, Yoo S, Yang TJ, Cho H, Hwang SW. (2010) Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3. J. Biol. Chem., 285 (25): 19362-71. [PMID:20395302]

3. Bang S, Yoo S, Yang TJ, Cho H, Hwang SW. (2011) Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. Pain, 152 (5): 1156-64. [PMID:21353389]

4. Bang S, Yoo S, Yang TJ, Cho H, Hwang SW. (2012) 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br. J. Pharmacol., 165 (3): 683-92. [PMID:21718307]

5. Borbíró I, Lisztes E, Tóth BI, Czifra G, Oláh A, Szöllosi AG, Szentandrássy N, Nánási PP, Péter Z, Paus R et al.. (2011) Activation of transient receptor potential vanilloid-3 inhibits human hair growth. J. Invest. Dermatol., 131 (8): 1605-14. [PMID:21593771]

6. Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM et al.. (2010) TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell, 141 (2): 331-43. [PMID:20403327]

7. Chung MK, Guler AD, Caterina MJ. (2005) Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J. Biol. Chem., 280 (16): 15928-41. [PMID:15722340]

8. Chung MK, Lee H, Caterina MJ. (2003) Warm temperatures activate TRPV4 in mouse 308 keratinocytes. J. Biol. Chem., 278 (34): 32037-46. [PMID:12783886]

9. Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ. (2004) 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J. Neurosci., 24 (22): 5177-82. [PMID:15175387]

10. Danso-Abeam D, Zhang J, Dooley J, Staats KA, Van Eyck L, Van Brussel T, Zaman S, Hauben E, Van de Velde M, Morren MA et al.. (2013) Olmsted syndrome: exploration of the immunological phenotype. Orphanet J Rare Dis, 8: 79. [PMID:23692804]

11. De Petrocellis L, Orlando P, Moriello AS, Aviello G, Stott C, Izzo AA, Di Marzo V. (2012) Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation. Acta Physiol (Oxf), 204 (2): 255-66. [PMID:21726418]

12. Doerner JF, Hatt H, Ramsey IS. (2011) Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis. J. Gen. Physiol., 137 (3): 271-88. [PMID:21321070]

13. Gomtsyan A, Schmidt RG, Bayburt EK, Gfesser GA, Voight EA, Daanen JF, Schmidt DL, Cowart MD, Liu H, Altenbach RJ et al.. (2016) Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J. Med. Chem., 59 (10): 4926-47. [PMID:27077528]

14. Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee LY, Wood JD, Zhu MX. (2004) 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem., 279 (34): 35741-8. [PMID:15194687]

15. Huang SM, Lee H, Chung MK, Park U, Yu YY, Bradshaw HB, Coulombe PA, Walker JM, Caterina MJ. (2008) Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2. J. Neurosci., 28 (51): 13727-37. [PMID:19091963]

16. Lin Z, Chen Q, Lee M, Cao X, Zhang J, Ma D, Chen L, Hu X, Wang H, Wang X et al.. (2012) Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome. Am. J. Hum. Genet., 90 (3): 558-64. [PMID:22405088]

17. Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM. (2006) More than cool: promiscuous relationships of menthol and other sensory compounds. Mol. Cell. Neurosci., 32 (4): 335-43. [PMID:16829128]

18. Mercado J, Gordon-Shaag A, Zagotta WN, Gordon SE. (2010) Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J. Neurosci., 30 (40): 13338-47. [PMID:20926660]

19. Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN, Spencer KS, Andahazy M, Story GM, Patapoutian A. (2005) Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science, 307 (5714): 1468-72. [PMID:15746429]

20. Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, Kashman Y, Huang SM, Lee H, Shohami E et al.. (2008) Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J., 22 (8): 3024-34. [PMID:18492727]

21. Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, Patapoutian A. (2002) A heat-sensitive TRP channel expressed in keratinocytes. Science, 296 (5575): 2046-9. [PMID:12016205]

22. Phelps CB, Wang RR, Choo SS, Gaudet R. (2010) Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J. Biol. Chem., 285 (1): 731-40. [PMID:19864432]

23. Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis JB. (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature, 418 (6894): 186-90. [PMID:12077606]

24. Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. (2008) Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS ONE, 3 (5): e2082. [PMID:18461159]

25. Vogt-Eisele AK, Weber K, Sherkheli MA, Vielhaber G, Panten J, Gisselmann G, Hatt H. (2007) Monoterpenoid agonists of TRPV3. Br. J. Pharmacol., 151 (4): 530-40. [PMID:17420775]

26. Xiao R, Tang J, Wang C, Colton CK, Tian J, Zhu MX. (2008) Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J. Biol. Chem., 283 (10): 6162-74. [PMID:18178557]

27. Xu H, Delling M, Jun JC, Clapham DE. (2006) Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat. Neurosci., 9 (5): 628-35. [PMID:16617338]

28. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature, 418 (6894): 181-6. [PMID:12077604]

29. Zhang X, Li L, McNaughton PA. (2008) Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron, 59 (3): 450-61. [PMID:18701070]

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How to cite this page

Julia F Doerner, David E. Clapham.
Transient Receptor Potential channels: TRPV3. Last modified on 03/05/2016. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=509.