RAMP1

Target id: 51

Nomenclature: RAMP1

Quaternary Structure: Complexes
AMY1 receptor
CGRP receptor
Gene and Protein Information
Receptor activity modifying protein
Species TM AA Chromosomal Location Gene Symbol Gene Name References
Human 1 148 2q36-q37.1 RAMP1 receptor activity modifying protein 1 1,3
Mouse 1 148 1 D Ramp1 receptor (calcitonin) activity modifying protein 1 1
Rat 1 148 9q36 Ramp1 receptor activity modifying protein 1
Previous and Unofficial Names
receptor activity modifying protein 1
receptor (G protein-coupled) activity modifying protein 1
Database Links
ChEMBL Target 100673 (Hs), 100439 (Rn)
DrugBank Target O60894 (Hs)
Ensembl Gene ENSG00000132329 (Hs), ENSMUSG00000034353 (Mm), ENSRNOG00000019926 (Rn)
Entrez Gene 10267 (Hs), 51801 (Mm), 58965 (Rn)
GenitoUrinary Development Molecular Anatomy Project Ramp1 (Mm)
Human Protein Atlas ENSG00000132329 (Hs)
KEGG Gene hsa:10267 (Hs), mmu:51801 (Mm), rno:58965 (Rn)
OMIM 605153 (Hs)
RefSeq Nucleotide NM_005855 (Hs), NM_016894 (Mm), NM_031645 (Rn)
RefSeq Protein NP_005846 (Hs), NP_058590 (Mm), NP_113833 (Rn)
UniProtKB O60894 (Hs), Q9JJ74 (Rn), Q9WTJ5 (Mm)
Wikipedia RAMP1 (Hs)
Protein Comments
In situ hybridisation studies of the rat brain have shown RAMP1 mRNA to be located predominantly in the cortex, caudate putamen and olfactory tubercles [4].

Immunochemistry shows RAMP1 to be present in the human middle meningeal, middle cerebral, pial and superficial temporal arteries [5].

Northern blotting showed mouse RAMP1 mRNA to be located predominantly in the lung, skeletal muscle and brain [2].

References

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1. Derst C, Engel H, Grzeschik K, Daut J. (2000) Genomic structure and chromosome mapping of human and mouse RAMP genes. Cytogenet Cell Genet90: 115-118. [PMID:11060459]

2. Husmann K, Sexton PM, Fischer JA, Born W. (2000) Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol162: 35-43. [PMID:10854696]

3. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature.393: 333-339. [PMID:9620797]

4. Oliver KR, Kane SA, Salvatore CA, Mallee JJ, Kinsey AM, Koblan KS, Keyvan-Fouladi N, Heavens RP, Wainwright A, Jacobson M, Dickerson IM, Hill RG. (2001) Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Eur J Neurosci14: 618-628. [PMID:11556887]

5. Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG. (2002) Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. J Cereb Blood Flow Metab22: 620-629. [PMID:11973435]

How to cite this page

RAMP1. Last modified on 22/10/2014. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=51.