K<sub>2P</sub>17.1 | Two P domain potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

K2P17.1

Target id: 526

Nomenclature: K2P17.1

Family: Two P domain potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for K2P17.1 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 332 6p21.1-2 KCNK17 potassium two pore domain channel subfamily K member 17 3
Previous and Unofficial Names
TALK2 | TASK4 | potassium channel, subfamily K, member 17 | potassium channel, two pore domain subfamily K, member 17
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics
Background current

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
NO Hs - - - - - 1
[1]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
chloroform Hs - - - 7x10-4 - 9x10-4 - 3
Conc range: 7x10-4 - 9x10-4 M [3]
Tissue Distribution
Heart, lung, liver, pancreas.
Species:  Human
Technique: 
References:  3
Clinically-Relevant Mutations and Pathophysiology
Disease:  Severe progressive cardiac conduction disorder
References:  2
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human G88R 262G>A Gain of function mutation 2
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. The open probability of K2P17.1 increases as pHo is raised above physiological levels, see K2P16.1.

References

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1. Duprat F, Girard C, Jarretou G, Lazdunski M. (2005) Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species. J. Physiol. (Lond.), 562 (Pt 1): 235-44. [PMID:15513946]

2. Friedrich C, Rinné S, Zumhagen S, Kiper AK, Silbernagel N, Netter MF, Stallmeyer B, Schulze-Bahr E, Decher N. (2014) Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder. EMBO Mol Med, 6 (7): 937-51. [PMID:24972929]

3. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F. (2001) Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochem. Biophys. Res. Commun., 282 (1): 249-56. [PMID:11263999]

Contributors

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How to cite this page

Leigh D. Plant, Douglas A. Bayliss, Daniel L. Minor, Jr., Gábor Czirják, Péter Enyedi, Florian Lesage, Francisco Sepúlveda, Steve A.N. Goldstein.
Two P domain potassium channels: K2P17.1. Last modified on 09/03/2017. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=526.