Jump to
Inwardly rectifying potassium channels
More information on this family may be found on the IUPHAR-DB family and introduction pages.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
|
Kir1.1
Show »« Hide
| Nomenclature |
Kir1.1
|
| Other names |
ROMK,
ROMK1,
ROMK2,
ROMK3,
Kir1.1,
Kcnj,
potassium inwardly-rectifying channel, subfamily J,
ATP-regulated potassium channel,
ATP-regulated potassium channel ROM-K,
ATP-sensitive inward rectifier potassium channel 1,
K+ channel protein,
KAB-1,
Potassium inwardly-rectifying channel subfamily J,
inward rectifier K(+) channel Kir1.1,
potassium channel, inwardly rectifying subfamily J member 1,
potassium inwardly-rectifying channel, subfamily J, member 1,
ROMK-2
|
| IUPHAR-DB |
Kir1.1
|
| Genes |
KCNJ1 (Hs), Kcnj1 (Mm), Kcnj1 (Rn) |
| Ensembl ID |
ENSG00000151704 (Hs), ENSMUSG00000041248 (Mm), ENSRNOG00000008779 (Rn)
|
| Functional characteristics |
Inward-rectifier current
|
|
|
Kir2.1
Show »« Hide
| Nomenclature |
Kir2.1
|
| Other names |
IRK1,
Kir2.1,
LQT7,
IRK-1,
RBL-IRK1,
inward rectifier K(+) channel Kir2.1,
inward rectifier potassium channel 2,
potassium channel, inwardly rectifying subfamily J member 2,
potassium inwardly-rectifying channel, subfamily J, member 2,
Kcnf1
|
| IUPHAR-DB |
Kir2.1
|
| Genes |
KCNJ2 (Hs), Kcnj2 (Mm), Kcnj2 (Rn) |
| Ensembl ID |
ENSG00000123700 (Hs), ENSMUSG00000041695 (Mm), ENSRNOG00000004720 (Rn)
|
| Endogenous inhibitors |
|
| Functional characteristics |
IK1 in heart, ‘strong’ inward–rectifier current
|
| Comment |
KIR2.1 is also inhibited by intracellular polyamines
|
|
|
Kir2.2
Show »« Hide
| Nomenclature |
Kir2.2
|
| Other names |
IRK2,
RB-IRK2,
MB-IRK2,
hIRK,
Kir2.2,
KCNJN1,
Kir2.2v,
hIRK1,
potassium inwardly-rectifying channel, subfamily J, inhibitor 1,
Kir2.1,
MGC156606,
ATP-sensitive inward rectifier potassium channel 12,
IRK-2,
inward rectifier K(+) channel Kir2.2,
potassium channel, inwardly rectifying subfamily J member 12,
potassium inwardly-rectifying channel, subfamily J, member 12
|
| IUPHAR-DB |
Kir2.2
|
| Genes |
KCNJ12 (Hs), Kcnj12 (Mm), Kcnj12 (Rn) |
| Ensembl ID |
ENSG00000184185 (Hs), ENSMUSG00000042529 (Mm), ENSRNOG00000002303 (Rn)
|
| Endogenous inhibitors |
|
| Functional characteristics |
IK1 in heart, ‘strong’ inward–rectifier current
|
| Comment |
KIR2.2 is also inhibited by intracellular polyamines
|
|
|
Kir2.3
Show »« Hide
| Nomenclature |
Kir2.3
|
| Other names |
IRK3,
HIR,
HRK1,
BIRK2,
BIR11,
hIRK2,
MB-IRK3,
mKir2.3,
Kir2.3,
mKir2.3,
IRK-3,
brain inwardly rectifying K(+) channel 2,
inward rectifier K(+) channel Kir2.3,
inward rectifier potassium channel 4,
potassium channel, inwardly rectifying subfamily J member 4,
Kir 2.3,
Kcnf2
|
| IUPHAR-DB |
Kir2.3
|
| Genes |
KCNJ4 (Hs), Kcnj4 (Mm), Kcnj4 (Rn) |
| Ensembl ID |
ENSG00000168135 (Hs), ENSMUSG00000044216 (Mm), ENSRNOG00000013869 (Rn)
|
| Endogenous inhibitors |
|
| Functional characteristics |
IK1 in heart, ‘strong’ inward–rectifier current
|
| Comment |
KIR2.3 is also inhibited by intracellular polyamines
|
|
|
Kir2.4
Show »« Hide
| Nomenclature |
Kir2.4
|
| Other names |
IRK4,
Kir2.4,
ATP-sensitive inward rectifier potassium channel 14,
IRK-4,
inward rectifier K(+) channel Kir2.4,
inwardly rectifying potassium channel Kir2.4,
potassium channel, inwardly rectifying subfamily J member 14,
potassium inwardly-rectifying channel J14,
potassium inwardly-rectifying channel, subfamily J, member 14,
A930026G01Rik
|
| IUPHAR-DB |
Kir2.4
|
| Genes |
KCNJ14 (Hs), Kcnj14 (Mm), Kcnj14 (Rn) |
| Ensembl ID |
ENSG00000182324 (Hs), ENSMUSG00000058743 (Mm)
|
| Endogenous inhibitors |
|
| Functional characteristics |
IK1 in heart, ‘strong’ inward–rectifier current
|
| Comment |
KIR2.4 is also inhibited by intracellular polyamines
|
|
|
Kir3.1
Show »« Hide
| Nomenclature |
Kir3.1
|
| Other names |
GIRK1,
KGA,
Kir3.1,
potassium channel, inwarding rectifying channel, subfamily J, member 3,
G protein-activated inward rectifier potassium channel 1,
GIRK-1,
KGB1,
inward rectifier K(+) channel Kir3.1,
potassium channel inwarding rectifying channel subfamily J member 3,
potassium channel subunit Kir3.1 type 3 delta,
potassium channel, inwardly rectifying subfamily J member 3,
potassium inwardly-rectifying channel subfamily J member 3,
potassium inwardly-rectifying channel, subfamily J, member 3,
Kcnf3
|
| IUPHAR-DB |
Kir3.1
|
| Genes |
KCNJ3 (Hs), Kcnj3 (Mm), Kcnj3 (Rn) |
| Ensembl ID |
ENSG00000162989 (Hs), ENSMUSG00000026824 (Mm), ENSRNOG00000005369 (Rn)
|
Endogenous activators
(EC50) |
|
| Functional characteristics |
G-protein-activated inward-rectifier current
|
| Comment |
KIR3.1 is also activated by Gβγ
|
|
|
Kir3.2
Show »« Hide
| Nomenclature |
Kir3.2
|
| Other names |
GIRK2,
hiGIRK2,
KATP-2,
BIR,
Kir3.2,
KCNJ7,
KATP2,
BIR1,
GIRK-2,
Kcnj6_predicted,
LOC360252,
G protein-activated inward rectifier potassium channel 2,
Potassium inwardly-rectifying channel subfamily J member 6,
inward rectifier K(+) channel Kir3.2,
potassium channel, inwardly rectifying subfamily J member 6,
potassium inwardly-rectifying channel, subfamily J, member 6,
potassium inwardly-rectifying channel, subfamily J, member 6 (predicted),
wv
|
| IUPHAR-DB |
Kir3.2
|
| Genes |
KCNJ6 (Hs), Kcnj6 (Mm), Kcnj6 (Rn) |
| Ensembl ID |
ENSG00000157542 (Hs), ENSMUSG00000043301 (Mm), ENSRNOG00000001658 (Rn)
|
Endogenous activators
(EC50) |
|
| Functional characteristics |
G-protein-activated inward-rectifier current
|
| Comment |
KIR3.2 is also activated by Gβγ
|
|
|
Kir3.3
Show »« Hide
| Nomenclature |
Kir3.3
|
| Other names |
GIRK3,
Kir3.3,
G protein-activated inward rectifier potassium channel 3,
GIRK-3,
inward rectifier K(+) channel Kir3.3,
inwardly rectifier K(+) channel Kir3.3,
potassium channel, inwardly rectifying subfamily J member 9,
potassium inwardly-rectifying channel, subfamily J, member 9,
1700085N21Rik
|
| IUPHAR-DB |
Kir3.3
|
| Genes |
KCNJ9 (Hs), Kcnj9 (Mm), Kcnj9 (Rn) |
| Ensembl ID |
ENSG00000162728 (Hs), ENSMUSG00000038026 (Mm), ENSRNOG00000007645 (Rn)
|
Endogenous activators
(EC50) |
|
| Functional characteristics |
G-protein-activated inward-rectifier current
|
| Comment |
KIR3.3 is also activated by Gβγ
|
|
|
Kir3.4
Show »« Hide
| Nomenclature |
Kir3.4
|
| Other names |
GIRK4,
KCNJ5,
KATP,
IKACh,
CIR,
Kir3.4,
KATP1,
LQT13,
MGC93525,
G protein-activated inward rectifier potassium channel 4,
GIRK-4,
KATP-1,
cardiac inward rectifier,
heart KATP channel,
inward rectifier K(+) channel Kir3.4,
potassium channel, inwardly rectifying subfamily J member 5,
potassium inwardly-rectifying channel, subfamily J, member 5
|
| IUPHAR-DB |
Kir3.4
|
| Genes |
KCNJ5 (Hs), Kcnj5 (Mm), Kcnj5 (Rn) |
| Ensembl ID |
ENSG00000120457 (Hs), ENSMUSG00000032034 (Mm), ENSRNOG00000033796 (Rn)
|
Endogenous activators
(EC50) |
|
| Functional characteristics |
G-protein-activated inward-rectifier current
|
| Comment |
KIR3.4 is also activated by Gβγ
|
|
|
Kir4.1
Show »« Hide
| Nomenclature |
Kir4.1
|
| Other names |
BIR10,
KAB-2,
BIRK-1,
Kir1.2,
Kir4.1,
Kir1.2,
ATP-sensitive inward rectifier potassium channel 10,
ATP-sensitive inward rectifier potassium channel KAB-2,
BIRK1,
brain-specific inwardly rectifying K(+) channel 1,
inward rectifier K(+) channel Kir4.1,
potassium channel, inwardly rectifying subfamily J member 10,
potassium inwardly-rectifying channel, subfamily J, member 10
|
| IUPHAR-DB |
Kir4.1
|
| Genes |
KCNJ10 (Hs), Kcnj10 (Mm), Kcnj10 (Rn) |
| Ensembl ID |
ENSG00000177807 (Hs), ENSMUSG00000044708 (Mm), ENSRNOG00000007705 (Rn)
|
| Functional characteristics |
Inward-rectifier current
|
|
|
Kir4.2
Show »« Hide
| Nomenclature |
Kir4.2
|
| Other names |
Kir1.3,
mLV1,
IRKK,
Kir4.2,
Kir1.3,
ATP-sensitive inward rectifier potassium channel 15,
inward rectifier K(+) channel Kir4.2,
potassium channel, inwardly rectifying subfamily J member 15,
potassium inwardly-rectifying channel, subfamily J, member 15,
4930414N08Rik,
AI182284,
AI267127
|
| IUPHAR-DB |
Kir4.2
|
| Genes |
KCNJ15 (Hs), Kcnj15 (Mm), Kcnj15 (Rn) |
| Ensembl ID |
ENSG00000157551 (Hs), ENSMUSG00000062609 (Mm), ENSRNOG00000001656 (Rn)
|
| Functional characteristics |
Inward-rectifier current
|
|
|
Kir5.1
Show »« Hide
| Nomenclature |
Kir5.1
|
| Other names |
BIR9,
Kir5.1,
inward rectifier K(+) channel Kir5.1,
inward rectifier potassium channel 16,
potassium channel, inwardly rectifying subfamily J member 16,
potassium inwardly-rectifying channel, subfamily J, member 16,
6430410F18Rik,
AI132396
|
| IUPHAR-DB |
Kir5.1
|
| Genes |
KCNJ16 (Hs), Kcnj16 (Mm), Kcnj16 (Rn) |
| Ensembl ID |
ENSG00000153822 (Hs), ENSMUSG00000051497 (Mm), ENSRNOG00000004713 (Rn)
|
| Functional characteristics |
Inward-rectifier current
|
|
|
Kir6.1
Show »« Hide
| Nomenclature |
Kir6.1
|
| Other names |
Kir6.1,
uKATP-1,
uKATP-1,
UKATP1,
inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive),
ATP-sensitive inward rectifier potassium channel 8,
Inwardly rectifying potassium channel gene subfamily J-8 (ATP sensitive),
inward rectifier K(+) channel Kir6.1,
inwardly rectifier K(+) channel Kir6.1,
potassium channel, inwardly rectifying subfamily J member 8,
potassium inwardly-rectifying channel, subfamily J, member 8,
gnite,
slmbr,
sltr,
AI448900
|
| IUPHAR-DB |
Kir6.1
|
| Genes |
KCNJ8 (Hs), Kcnj8 (Mm), Kcnj8 (Rn) |
| Ensembl ID |
ENSG00000121361 (Hs), ENSMUSG00000030247 (Mm), ENSRNOG00000013463 (Rn)
|
|
Associated subunits
|
SUR1, SUR2A, SUR2B
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
ATP-sensitive, inward-rectifier current
|
|
|
Kir6.2
Show »« Hide
| Nomenclature |
Kir6.2
|
| Other names |
Kir6.2,
βIR,
KATP-β,
BIR,
ATP-sensitive inward rectifier potassium channel 11,
inward rectifier K(+) channel Kir6.2,
potassium channel, inwardly rectifying subfamily J member 11,
potassium inwardly-rectifying channel subfamily J member 11,
AI842722,
AW491124
|
| IUPHAR-DB |
Kir6.2
|
| Genes |
KCNJ11 (Hs), Kcnj11 (Mm), Kcnj11 (Rn) |
| Ensembl ID |
ENSG00000187486 (Hs), ENSMUSG00000070561 (Mm), ENSRNOG00000021128 (Rn)
|
|
Associated subunits
|
SUR1, SUR2A, SUR2B
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
ATP-sensitive, inward-rectifier current
|
|
|
Kir7.1
Show »« Hide
| Nomenclature |
Kir7.1
|
| Other names |
IRK13,
Kir7.1,
Kir1.4,
inward rectifier K(+) channel Kir7.1,
inward rectifier potassium channel 13,
potassium channel, inwardly rectifying subfamily J member 13,
potassium inwardly-rectifying channel, subfamily J, member 13
|
| IUPHAR-DB |
Kir7.1
|
| Genes |
KCNJ13 (Hs), Kcnj13 (Mm), Kcnj13 (Rn) |
| Ensembl ID |
ENSG00000115474 (Hs), ENSMUSG00000079436 (Mm), ENSRNOG00000016057 (Rn)
|
| Functional characteristics |
Inward-rectifier current
|
|
More information on this family may be found on the IUPHAR-DB family and introduction pages.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
|
K2P1.1
Show »« Hide
| Nomenclature |
K2P1.1
|
| Other names |
KCNK1,
TWIK-1,
hOHO,
K2P1.1,
DPK,
Twik,
inward rectifying potassium channel protein TWIK-1,
potassium channel subfamily K member 1,
putative potassium channel TWIK,
rTWIK,
AI788889
|
| IUPHAR-DB |
K2P1.1
|
| Genes |
KCNK1 (Hs), Kcnk1 (Mm), Kcnk1 (Rn) |
| Ensembl ID |
ENSG00000135750 (Hs), ENSMUSG00000033998 (Mm), ENSRNOG00000019937 (Rn)
|
| Functional characteristics |
Background current
|
| Comment |
K2P1.1 is inhibited by acid pHi
|
|
|
K2P2.1
Show »« Hide
| Nomenclature |
K2P2.1
|
| Other names |
KCNK2,
TREK-1,
TPKC1,
K2P2.1,
rTREK1d,
arachidonic acid sensitive tandem pore domain potassium channel,
ion transport membrane protein,
potassium channel subfamily K member 2,
potassium channel, subfamily K, member 2,
tandem-pore-domain potassium channel TREK-1,
AI848635
|
| IUPHAR-DB |
K2P2.1
|
| Genes |
KCNK2 (Hs), Kcnk2 (Mm), Kcnk2 (Rn) |
| Ensembl ID |
ENSG00000082482 (Hs), ENSMUSG00000037624 (Mm), ENSRNOG00000002653 (Rn)
|
Endogenous activators
(EC50) |
|
Activators
(EC50) |
|
| Functional characteristics |
Background current
|
| Comment |
K2P2.1 is also activated by stretch, heat and acid pHi
|
|
|
K2P3.1
Show »« Hide
| Nomenclature |
K2P3.1
|
| Other names |
KCNK3,
TASK-1,
TBAK-1,
OAT-1,
K2P3.1,
TASK,
rTASK,
TWIK-related acid-sensitive K(+) channel 1,
TWIK-related acid-sensitive K+ channel,
acid-sensitive potassium channel protein TASK-1,
potassium channel subfamily K member 3,
potassium channel, subfamily K, member 3,
two pore K(+) channel KT3.1,
two pore potassium channel KT3.1,
cTBAK-1
|
| IUPHAR-DB |
K2P3.1
|
| Genes |
KCNK3 (Hs), Kcnk3 (Mm), Kcnk3 (Rn) |
| Ensembl ID |
ENSG00000171303 (Hs), ENSMUSG00000049265 (Mm), ENSRNOG00000009790 (Rn)
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
Background current
|
| Comment |
K2P3.1 is also activated by alkakine pHo and inhibited by acid pHo
|
|
|
K2P4.1
Show »« Hide
| Nomenclature |
K2P4.1
|
| Other names |
KCNK4,
TRAAK,
K2P4.1,
KT4.1,
potassium channel subfamily K member 4,
potassium inwardly-rectifying channel subfamily K member 4,
potassium inwardly-rectifying channel, subfamily K, member 4,
TRAAKt
|
| IUPHAR-DB |
K2P4.1
|
| Genes |
KCNK4 (Hs), Kcnk4 (Mm), Kcnk4 (Rn) |
| Ensembl ID |
ENSG00000182450 (Hs), ENSMUSG00000024957 (Mm), ENSRNOG00000021140 (Rn)
|
Endogenous activators
(EC50) |
|
Activators
(EC50) |
|
| Functional characteristics |
Background current
|
| Comment |
K2P4.1 is also activated by stretch, heat and acid pHi
|
|
|
K2P5.1
Show »« Hide
| Nomenclature |
K2P5.1
|
| Other names |
KCNK5,
TASK-2,
K2P5.1,
LOC364241,
TASK2,
potassium channel subfamily K member 5,
potassium channel, subfamily K, member 5,
similar to potassium channel TASK2
|
| IUPHAR-DB |
K2P5.1
|
| Genes |
KCNK5 (Hs), Kcnk5 (Mm), Kcnk5 (Rn) |
| Ensembl ID |
ENSG00000164626 (Hs), ENSMUSG00000023243 (Mm)
|
| Functional characteristics |
Background current
|
| Comment |
K2P5.1 is activated by alkaline pHo
|
|
|
K2P6.1
Show »« Hide
| Nomenclature |
K2P6.1
|
| Other names |
KCNK6,
TWIK-2,
TOSS,
K2P6.1,
Twik2,
potassium channel subfamily K member 6 (TWIK-2),
potassium channel, subfamily K, member 6,
potassium channel, subfamily K, member 6 (TWIK-2),
potassium inwardly-rectifying channel, subfamily K, member 6,
D7Ertd764e
|
| IUPHAR-DB |
K2P6.1
|
| Genes |
KCNK6 (Hs), Kcnk6 (Mm), Kcnk6 (Rn) |
| Ensembl ID |
ENSG00000099337 (Hs), ENSMUSG00000046410 (Mm), ENSRNOG00000020598 (Rn)
|
| Functional characteristics |
Background current
|
| Comment |
K2P6.1 is inhibited by acid pHi
|
|
|
K2P7.1
Show »« Hide
| Nomenclature |
K2P7.1
|
| Other names |
KCNK7,
kcnk8,
K2P7.1,
LOC499303,
RGD1565025_predicted,
similar to two pore domain K+ channel subunit,
similar to two pore domain K+ channel subunit (predicted),
Knot,
Mlk3,
2310014G03Rik
|
| IUPHAR-DB |
K2P7.1
|
| Genes |
KCNK7 (Hs), Kcnk7 (Mm), RGD1565025 (Rn) |
| Ensembl ID |
ENSG00000173338 (Hs), ENSMUSG00000024936 (Mm), ENSRNOG00000020784 (Rn)
|
| Functional characteristics |
Background current
|
| Comment |
K2P7.1 is inhibited by acid pHi
|
|
|
K2P9.1
Show »« Hide
| Nomenclature |
K2P9.1
|
| Other names |
KCNK9,
TASK-3,
K2P9.1,
TASK3,
TWIK-related acid-sensitive K(+) channel 3,
acid-sensitive potassium channel protein TASK-3,
potassium channel subfamily K member 9,
potassium channel subfamily K member 9 (Task-3),
potassium channel, subfamily K, member 9 (Task-3),
two pore K(+) channel KT3.2,
two pore potassium channel KT3.2
|
| IUPHAR-DB |
K2P9.1
|
| Genes |
KCNK9 (Hs), Kcnk9 (Mm), Kcnk9 (Rn) |
| Ensembl ID |
ENSG00000169427 (Hs), ENSMUSG00000036760 (Mm), ENSRNOG00000009265 (Rn)
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
Background current
|
| Comment |
K2P9.1 is also inhibited by acid pHo
|
|
|
K2P10.1
Show »« Hide
| Nomenclature |
K2P10.1
|
| Other names |
KCNK10,
TREK-2,
K2P10.1,
TREK2,
TREK-2 K(+) channel subunit,
outward rectifying potassium channel protein TREK-2,
potassium channel TREK-2,
potassium channel subfamily K member 10,
potassium channel, subfamily K, member 10,
1700024D23Rik,
3010005K24Rik
|
| IUPHAR-DB |
K2P10.1
|
| Genes |
KCNK10 (Hs), Kcnk10 (Mm), Kcnk10 (Rn) |
| Ensembl ID |
ENSG00000100433 (Hs), ENSMUSG00000033854 (Mm), ENSRNOG00000003813 (Rn)
|
Endogenous activators
(EC50) |
|
Activators
(EC50) |
|
| Functional characteristics |
Background current
|
| Comment |
K2P10.1 is also activated by stretch, heat and acid pHi
|
|
|
K2P12.1
Show »« Hide
| Nomenclature |
K2P12.1
|
| Other names |
KCNK12,
THIK-2,
K2P12.1,
THIK2,
potassium channel subfamily K member 12,
potassium channel, subfamily K, member 12,
tandem pore domain halothane-inhibited potassium channel 2,
tandem pore domain potassium channel THIK-2,
mntk1
|
| IUPHAR-DB |
K2P12.1
|
| Genes |
KCNK12 (Hs), Kcnk12 (Mm), Kcnk12 (Rn) |
| Ensembl ID |
ENSG00000184261 (Hs), ENSMUSG00000050138 (Mm), ENSRNOG00000016110 (Rn)
|
| Inhibitors |
|
| Functional characteristics |
Background current
|
|
|
K2P13.1
Show »« Hide
| Nomenclature |
K2P13.1
|
| Other names |
KCNK13,
THIK-1,
K2P13.1,
THIK1,
prdx1,
potassium channel subfamily K member 13,
potassium channel, subfamily K, member 13,
tandem pore domain halothane-inhibited potassium channel 1,
tandem pore domain potassium channel THIK-1,
LOC380778,
LOC381712,
BB085247,
Gm1570,
F730021E22Rik,
Gm1685
|
| IUPHAR-DB |
K2P13.1
|
| Genes |
KCNK13 (Hs), Kcnk13 (Mm), Kcnk13 (Rn) |
| Ensembl ID |
ENSG00000152315 (Hs), ENSMUSG00000045404 (Mm), ENSRNOG00000003926 (Rn)
|
| Inhibitors |
|
| Functional characteristics |
Background current
|
|
|
K2P15.1
Show »« Hide
| Nomenclature |
K2P15.1
|
| Other names |
KCNK15,
TASK-5,
KT3.3,
K2P15.1,
KCNK11,
KCNK14,
dJ781B1.1,
KIAA0237,
TASK5,
TWIK-related acid-sensitive K(+) channel 5,
acid-sensitive potassium channel protein TASK-5,
potassium channel subfamily K member 15,
potassium channel subfamily K member 15 (TASK-5),
potassium channel, subfamily K, member 15 (TASK-5),
rTASK-5
|
| IUPHAR-DB |
K2P15.1
|
| Genes |
KCNK15 (Hs), Kcnk15 (Mm), Kcnk15 (Rn) |
| Ensembl ID |
ENSG00000124249 (Hs), ENSMUSG00000035238 (Mm), ENSRNOG00000010816 (Rn)
|
Activators
(EC50) |
|
| Functional characteristics |
Background current
|
| Comment |
K2P15.1 is inhibited by acid pHo
|
|
|
K2P16.1
Show »« Hide
| Nomenclature |
K2P16.1
|
| Other names |
KCNK16,
TALK-1,
K2P16.1,
TALK1,
LOC688996,
potassium channel subfamily K member 16,
potassium channel, subfamily K, member 16,
similar to potassium channel, subfamily K, member 16,
4731413G05Rik
|
| IUPHAR-DB |
K2P16.1
|
| Genes |
KCNK16 (Hs), Kcnk16 (Mm), Kcnk16 (Rn) |
| Ensembl ID |
ENSG00000095981 (Hs), ENSMUSG00000023387 (Mm), ENSRNOG00000006422 (Rn)
|
| Functional characteristics |
Background current
|
| Comment |
K2P16.1 is activated by alkaline pHo
|
|
|
K2P17.1
Show »« Hide
| Nomenclature |
K2P17.1
|
| Other names |
KCNK17,
TASK-4,
TALK-2,
K2P17.1,
TALK2,
TASK4
|
| IUPHAR-DB |
K2P17.1
|
| Genes |
KCNK17 (Hs) |
| Ensembl ID |
ENSG00000124780 (Hs)
|
| Functional characteristics |
Background current
|
| Comment |
K2P17.1 is activated by alkaline pHo
|
|
|
K2P18.1
Show »« Hide
| Nomenclature |
K2P18.1
|
| Other names |
KCNK18,
TRESK-1/TRESK-2,
K2P18.1,
TRESK-2,
TRESK2,
TRESK,
TRIK,
TWIK related spinal cord K+ channel,
potassium channel subfamily K member 18,
potassium channel, subfamily K, member 18,
tandem-pore K+ (K(2P)) channel,
two-pore-domain potassium channel TRESK,
LOC332396,
Gm781
|
| IUPHAR-DB |
K2P18.1
|
| Genes |
KCNK18 (Hs), Kcnk18 (Mm), Kcnk18 (Rn) |
| Ensembl ID |
ENSG00000186795 (Hs), ENSMUSG00000040901 (Mm), ENSRNOG00000032706 (Rn)
|
| Endogenous inhibitors |
|
| Functional characteristics |
Background current
|
|
Voltage-gated potassium channels
More information on this family may be found on the IUPHAR-DB family and introduction pages.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
|
Kv1.1
Show »« Hide
| Nomenclature |
Kv1.1
|
| Other names |
HuK (I),
MBK1,
MK1,
RCK1,
RBK1,
Kcn1,
HBK1,
AEMK,
Kv1.1,
HUK1,
Kcna,
Kcpvd,
potassium (K+) channel protein, voltage dependent,
IA,
Potassium voltage gated channel, shaker related subfamily, member 1,
RBKI,
potassium (K+) channel protein voltage dependent,
potassium voltage gated channel shaker related subfamily member 1,
potassium voltage-gated channel subfamily A member 1,
potassium voltage-gated channel, shaker-related subfamily, member 1,
voltage-gated potassium channel subunit Kv1.1,
mouse brain potassium channel protein-1,
Shak,
Mk-1,
Kca1-1,
mceph,
AI840627
|
| IUPHAR-DB |
Kv1.1
|
| Genes |
KCNA1 (Hs), Kcna1 (Mm), Kcna1 (Rn) |
| Ensembl ID |
ENSG00000111262 (Hs), ENSMUSG00000047976 (Mm), ENSRNOG00000019750 (Rn)
|
|
Associated subunits
|
Kv β1 and Kv β2
|
| Inhibitors |
|
| Functional characteristics |
KV
|
|
|
Kv1.2
Show »« Hide
| Nomenclature |
Kv1.2
|
| Other names |
HuK (IV),
MK2,
BK2,
RCK5,
RAK,
BGK5,
XSha2,
NGK1,
HBK51,
Kv1.2,
HK4,
Potassium (K+) channel protein alpha 2 voltage dependent,
Potassium (K+) channel protein alpha 2, voltage dependent,
Potassium voltage gated channel shaker related subfamily member 2,
RBK2,
potassium voltage gated channel, shaker related subfamily, member 2 ,
potassium voltage-gated channel subfamily A member 2,
potassium voltage-gated channel, shaker-related subfamily, member 2,
voltage-gated potassium channel subunit Kv1.2,
Mk-2,
Kca1-2,
Akr6a4
|
| IUPHAR-DB |
Kv1.2
|
| Genes |
KCNA2 (Hs), Kcna2 (Mm), Kcna2 (Rn) |
| Ensembl ID |
ENSG00000177301 (Hs), ENSMUSG00000040724 (Mm), ENSRNOG00000018285 (Rn)
|
|
Associated subunits
|
Kv β1 and Kv β2
|
| Inhibitors |
|
| Functional characteristics |
KV
|
|
|
Kv1.3
Show »« Hide
| Nomenclature |
Kv1.3
|
| Other names |
MK3,
MBK3,
RCK3,
hPCN3,
HuK (III),
HLK3,
RGK5,
KV3,
HGK5,
n-channel,
Kv1.3,
potassium voltage gated channel, shaker related subfamily, member 3 ,
potassium voltage-gated channel subfamily A member 3,
potassium voltage-gated channel, shaker-related subfamily, member 3,
voltage-gated potassium channel subunit Kv1.3,
voltage-gated potassium channel subunit Kv3,
Mk-3,
Kca1-3
|
| IUPHAR-DB |
Kv1.3
|
| Genes |
KCNA3 (Hs), Kcna3 (Mm), Kcna3 (Rn) |
| Ensembl ID |
ENSG00000177272 (Hs), ENSMUSG00000047959 (Mm), ENSRNOG00000018116 (Rn)
|
|
Associated subunits
|
Kv β1 and Kv β2
|
| Inhibitors |
|
| Functional characteristics |
KV
|
|
|
Kv1.4
Show »« Hide
| Nomenclature |
Kv1.4
|
| Other names |
HuK (II),
hPCN2,
HK1,
RHK1,
RK4,
RK8,
MK4,
Kv1.4,
RCK4,
KCNA4L,
potassium voltage-gated channel, shaker-related subfamily, member 4-like,
KCHAN,
Kv4,
RK3,
potassium voltage gated channel, shaker related subfamily, member 4 ,
potassium voltage-gated channel subfamily A member 4,
potassium voltage-gated channel, shaker-related subfamily, member 4,
voltage-gated potassium channel subunit Kv1.4
|
| IUPHAR-DB |
Kv1.4
|
| Genes |
KCNA4 (Hs), Kcna4 (Mm), Kcna4 (Rn) |
| Ensembl ID |
ENSG00000182255 (Hs), ENSMUSG00000042604 (Mm), ENSRNOG00000004918 (Rn)
|
|
Associated subunits
|
Kv β1 and Kv β2
|
| Inhibitors |
|
| Functional characteristics |
KA
|
|
|
Kv1.5
Show »« Hide
| Nomenclature |
Kv1.5
|
| Other names |
HpCN1,
HK2,
HCK1,
KV1,
fHK,
RK3,
RMK2,
HuK (II),
Kv1.5,
Potassium (K+) channel protein alpha 5,
RCK7,
RK4,
potassium voltage gated channel shaker related subfamily member 5,
potassium voltage gated channel, shaker related subfamily, member 5,
potassium voltage-gated channel subfamily A member 5,
potassium voltage-gated channel, shaker-related subfamily, member 5,
voltage-gated potassium channel subunit Kv1.5
|
| IUPHAR-DB |
Kv1.5
|
| Genes |
KCNA5 (Hs), Kcna5 (Mm), Kcna5 (Rn) |
| Ensembl ID |
ENSG00000130037 (Hs), ENSMUSG00000045534 (Mm), ENSRNOG00000019719 (Rn)
|
|
Associated subunits
|
Kv β1 and Kv β2
|
| Functional characteristics |
KV
|
|
|
Kv1.6
Show »« Hide
| Nomenclature |
Kv1.6
|
| Other names |
HBK2,
MK1.6,
RCK2,
KV2,
Kv1.6,
Kv1.6,
potassium channel-Kv2,
potassium voltage gated channel shaker related subfamily member 6,
potassium voltage-gated channel subfamily A member 6,
voltage-gated potassium channel subunit Kv1.6,
voltage-gated potassium channel subunit Kv2
|
| IUPHAR-DB |
Kv1.6
|
| Genes |
KCNA6 (Hs), Kcna6 (Mm), Kcna6 (Rn) |
| Ensembl ID |
ENSG00000151079 (Hs), ENSMUSG00000038077 (Mm), ENSRNOG00000019753 (Rn)
|
|
Associated subunits
|
Kv β1 and Kv β2
|
| Inhibitors |
|
| Functional characteristics |
KV
|
|
|
Kv1.7
Show »« Hide
| Nomenclature |
Kv1.7
|
| Other names |
HAK6,
Kcna7,
KCNA7,
Kv1.7,
Kcna7_predicted,
LOC365241,
potassium voltage-gated channel subfamily A member 7,
potassium voltage-gated channel, shaker-related subfamily, member 7,
potassium voltage-gated channel, shaker-related subfamily, member 7 (predicted)
|
| IUPHAR-DB |
Kv1.7
|
| Genes |
KCNA7 (Hs), Kcna7 (Mm), Kcna7 (Rn) |
| Ensembl ID |
ENSG00000104848 (Hs), ENSMUSG00000038201 (Mm), ENSRNOG00000020779 (Rn)
|
|
Associated subunits
|
Kv β1 and Kv β2
|
| Functional characteristics |
KV
|
|
|
Kv1.8
Show »« Hide
| Nomenclature |
Kv1.8
|
| Other names |
kv1.10,
Kcn1,
Kv1.8,
KCNA10,
Kcna10_predicted,
cyclic GMP gated potassium channel,
potassium voltage-gated channel subfamily A member 10,
potassium voltage-gated channel, shaker-related subfamily, member 10,
potassium voltage-gated channel, shaker-related subfamily, member 10 (predicted),
Kcna8,
Gm1962
|
| IUPHAR-DB |
Kv1.8
|
| Genes |
KCNA10 (Hs), Kcna10 (Mm), Kcna10 (Rn) |
| Ensembl ID |
ENSG00000143105 (Hs), ENSMUSG00000042861 (Mm), ENSRNOG00000018283 (Rn)
|
|
Associated subunits
|
Kv β1 and Kv β2
|
| Functional characteristics |
KV
|
|
|
Kv2.1
Show »« Hide
| Nomenclature |
Kv2.1
|
| Other names |
hDRK1,
DRK1,
DRK1PC,
Kcr1-1,
Shab,
RP23-19L12.6,
Kv2.1,
delayed rectifier potassium channel 1,
potassium channel Kv2.1,
potassium voltage gated channel, Shab-related subfamily, member 1,
potassium voltage-gated channel subfamily B member 1,
voltage-gated potassium channel subunit Kv2.1
|
| IUPHAR-DB |
Kv2.1
|
| Genes |
KCNB1 (Hs), Kcnb1 (Mm), Kcnb1 (Rn) |
| Ensembl ID |
ENSG00000158445 (Hs), ENSMUSG00000050556 (Mm)
|
|
Associated subunits
|
Kv5.1, Kv6.1-6.4, Kv8.1-8.2 and Kv9.1-9.3
|
| Inhibitors |
|
| Functional characteristics |
KV
|
|
|
Kv2.2
Show »« Hide
| Nomenclature |
Kv2.2
|
| Other names |
CDRK,
9630047L19Rik,
BB130875,
Kv2.2,
potassium voltage gated channel, Shab-related subfamily, member 2,
potassium voltage-gated channel subfamily B member 2,
voltage-gated potassium channel subunit Kv2.2
|
| IUPHAR-DB |
Kv2.2
|
| Genes |
KCNB2 (Hs), Kcnb2 (Mm), Kcnb2 (Rn) |
| Ensembl ID |
ENSG00000182674 (Hs), ENSMUSG00000030525 (Mm), ENSRNOG00000028991 (Rn)
|
|
Associated subunits
|
Kv5.1, Kv6.1-6.4, Kv8.1-8.2 and Kv9.1-9.3
|
| Inhibitors |
|
|
|
Kv3.1
Show »« Hide
| Nomenclature |
Kv3.1
|
| Other names |
Kv3.1,
NGK2,
KV4,
KShIIIB,
Raw2,
C230009H10Rik,
Kcr2-1,
Shaw,
MGC129855,
NGK2-KV4,
potassium channel gene 1,
potassium voltage gated channel, Shaw-related subfamily, member 1,
potassium voltage-gated channel subfamily C member 1,
voltage-gated potassium channel subunit Kv3.1,
voltage-gated potassium channel subunit Kv4
|
| IUPHAR-DB |
Kv3.1
|
| Genes |
KCNC1 (Hs), Kcnc1 (Mm), Kcnc1 (Rn) |
| Ensembl ID |
ENSG00000129159 (Hs), ENSMUSG00000058975 (Mm), ENSRNOG00000011380 (Rn)
|
| Inhibitors |
|
| Functional characteristics |
KV
|
|
|
Kv3.2
Show »« Hide
| Nomenclature |
Kv3.2
|
| Other names |
RKShIIIA,
Raw1,
kv3.2a,
rkv3.2b,
rkv3.2c,
AW047325,
B230117I07,
Kv3.2,
KShIIIA,
potassium voltage gated channel, Shaw-related subfamily, member 2,
potassium voltage-gated channel subfamily C member 2,
voltage-gated potassium channel subunit Kv3.2
|
| IUPHAR-DB |
Kv3.2
|
| Genes |
KCNC2 (Hs), Kcnc2 (Mm), Kcnc2 (Rn) |
| Ensembl ID |
ENSG00000166006 (Hs), ENSMUSG00000035681 (Mm), ENSRNOG00000004077 (Rn)
|
| Inhibitors |
|
| Functional characteristics |
KV
|
|
|
Kv3.3
Show »« Hide
| Nomenclature |
Kv3.3
|
| Other names |
hkv3.3,
mkv3.3,
kv3.3b,
RKShIIID,
SCA13,
Kv3.3,
spinocerebellar ataxia 13,
KShIIID,
potassium voltage-gated channel subfamily C member 3,
voltage-gated potassium channel subunit Kv3.3,
Kcr2-3
|
| IUPHAR-DB |
Kv3.3
|
| Genes |
KCNC3 (Hs), Kcnc3 (Mm), Kcnc3 (Rn) |
| Ensembl ID |
ENSG00000131398 (Hs), ENSMUSG00000062785 (Mm), ENSRNOG00000019959 (Rn)
|
| Inhibitors |
|
| Functional characteristics |
KA
|
|
|
Kv3.4
Show »« Hide
| Nomenclature |
Kv3.4
|
| Other names |
Raw3,
mkv3.4,
HKShIIIC,
C1orf30,
Kv3.4,
chromosome 1 open reading frame 30,
Kcnc4,
LOC684516,
potassium voltage-gated channel subfamily C member 4,
potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3),
similar to Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3),
voltage-gated potassium channel subunit Kv3.4,
Kcr2-4,
AI850292
|
| IUPHAR-DB |
Kv3.4
|
| Genes |
KCNC4 (Hs), Kcnc4 (Mm), Kcnc4 (Rn) |
| Ensembl ID |
ENSG00000116396 (Hs), ENSMUSG00000027895 (Mm)
|
|
Associated subunits
|
MiRP2 is an associated subunit for Kv3.4
|
| Inhibitors |
|
| Functional characteristics |
KA
|
|
|
Kv4.1
Show »« Hide
| Nomenclature |
Kv4.1
|
| Other names |
RP23-109E24.9,
1110037K09Rik,
Kca2-1,
Shal,
mShal1,
Potassium voltage-gated channel subfamily D member 1,
Kv4.1,
potassium voltage gated channel Shal-related family member 1,
potassium voltage gated channel, Shal-related family, member 1,
potassium voltage-gated channel, Shal-related family, member 1,
potassium voltage-gated channel, Shal-related subfamily, member 1
|
| IUPHAR-DB |
Kv4.1
|
| Genes |
KCND1 (Hs), Kcnd1 (Mm), Kcnd1 (Rn) |
| Ensembl ID |
ENSG00000102057 (Hs), ENSMUSG00000009731 (Mm), ENSRNOG00000039544 (Rn)
|
|
Associated subunits
|
KChIP and KChAP
|
| Functional characteristics |
KA
|
|
|
Kv4.2
Show »« Hide
| Nomenclature |
Kv4.2
|
| Other names |
Potassium voltage-gated channel subfamily D member 2,
RK5,
Shal1,
KIAA1044,
MGC119702,
MGC119703,
Kv4.2,
potassium voltage gated channel, Shal-related family, member 2,
voltage-gated potassium channel subunit Kv4.2,
AI839615,
AW555701,
R75121
|
| IUPHAR-DB |
Kv4.2
|
| Genes |
KCND2 (Hs), Kcnd2 (Mm), Kcnd2 (Rn) |
| Ensembl ID |
ENSG00000184408 (Hs), ENSMUSG00000060882 (Mm), ENSRNOG00000029610 (Rn)
|
|
Associated subunits
|
KChIP and KChAP
|
| Functional characteristics |
KA
|
|
|
Kv4.3
Show »« Hide
| Nomenclature |
Kv4.3
|
| Other names |
Potassium voltage-gated channel subfamily D member 3,
KCND3L,
KCND3S,
KSHIVB,
MGC142035,
MGC142037,
OTTHUMP00000063948,
Kv4.3,
potassium voltage gated channel, Shal-related family, member 3,
voltage-gated potassium channel subunit Kv4.3,
potassium channel Kv4.3L,
potassium channel Kv4.3M,
AW045978
|
| IUPHAR-DB |
Kv4.3
|
| Genes |
KCND3 (Hs), Kcnd3 (Mm), Kcnd3 (Rn) |
| Ensembl ID |
ENSG00000171385 (Hs), ENSMUSG00000040896 (Mm), ENSRNOG00000014686 (Rn)
|
|
Associated subunits
|
KChIP and KChAP
|
| Functional characteristics |
KA
|
|
|
Kv5.1
Show »« Hide
| Nomenclature |
Kv5.1
|
| Other names |
KH1,
IK8,
KCNF,
Kv5.1,
potassium voltage-gated channel, subfamily F, member 1,
LOC382571,
Gm1182
|
| IUPHAR-DB |
Kv5.1
|
| Genes |
KCNF1 (Hs), Kcnf1 (Mm), Kcnf1 (Rn) |
| Ensembl ID |
ENSG00000162975 (Hs), ENSMUSG00000051726 (Mm), ENSRNOG00000024310 (Rn)
|
|
|
Kv6.1
Show »« Hide
| Nomenclature |
Kv6.1
|
| Other names |
KH2,
K13,
KCNG1,
MGC12878,
KCNG,
Kv6.1,
potassium voltage-gated channel subfamily G member 1,
potassium voltage-gated channel, subfamily G, member 1,
OTTMUSG00000016048,
AW536275
|
| IUPHAR-DB |
Kv6.1
|
| Genes |
KCNG1 (Hs), Kcng1 (Mm), Kcng1 (Rn) |
| Ensembl ID |
ENSG00000026559 (Hs), ENSMUSG00000074575 (Mm), ENSRNOG00000012144 (Rn)
|
|
|
Kv6.2
Show »« Hide
| Nomenclature |
Kv6.2
|
| Other names |
KCNG2,
KCNF2,
Kv6.2,
Kcng2_predicted,
LOC307234,
cardiac potassium channel subunit (Kv6.2),
potassium voltage-gated channel subfamily G member 2,
potassium voltage-gated channel, subfamily G, member 2,
potassium voltage-gated channel, subfamily G, member 2 (predicted),
voltage-gated potassium channel subunit Kv6.2,
AA591524
|
| IUPHAR-DB |
Kv6.2
|
| Genes |
KCNG2 (Hs), Kcng2 (Mm), Kcng2 (Rn) |
| Ensembl ID |
ENSG00000178342 (Hs), ENSMUSG00000059852 (Mm), ENSRNOG00000017189 (Rn)
|
|
|
Kv6.3
Show »« Hide
| Nomenclature |
Kv6.3
|
| Other names |
kv10.1,
kv10.1a,
kv10.1b,
Kv6.3,
Kv10.1,
potassium voltage-gated channel subfamily G member 3,
voltage-gated potassium channel 6.3,
voltage-gated potassium channel subunit Kv10.1,
voltage-gated potassium channel subunit Kv6.3,
potassium voltage-gated channel, subfamily G, member 3,
Kv10.1a,
Kv10.1b
|
| IUPHAR-DB |
Kv6.3
|
| Genes |
KCNG3 (Hs), Kcng3 (Mm), Kcng3 (Rn) |
| Ensembl ID |
ENSG00000171126 (Hs), ENSMUSG00000045053 (Mm), ENSRNOG00000004535 (Rn)
|
|
|
Kv6.4
Show »« Hide
| Nomenclature |
Kv6.4
|
| Other names |
4921535I01Rik,
AW049024,
kv6.3,
MGC129609,
MGC4558,
Kv6.4,
Kcng4_predicted,
LOC307900,
potassium voltage-gated channel subfamily G member 4,
potassium voltage-gated channel, subfamily G, member 4,
potassium voltage-gated channel, subfamily G, member 4 (predicted),
KV6.3
|
| IUPHAR-DB |
Kv6.4
|
| Genes |
KCNG4 (Hs), Kcng4 (Mm), Kcng4 (Rn) |
| Ensembl ID |
ENSG00000168418 (Hs), ENSMUSG00000045246 (Mm), ENSRNOG00000015746 (Rn)
|
|
|
Kv7.1
Show »« Hide
| Nomenclature |
Kv7.1
|
| Other names |
slow delayed rectifier,
Kv7.1,
KCNA8 ,
KCNA9,
KVLQT1,
LQT,
KCNA8,
JLNS1,
LQT1,
Jervell and Lange-Nielsen syndrome 1,
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,
KQT-like 1,
potassium voltage-gated channel subfamily KQT member 1,
potassium voltage-gated channel, KQT-like subfamily, member 1,
potassium voltage-gated channel, subfamily Q, member 1,
voltage-gated potassium channel subunit Kv7.1,
AW559127
|
| IUPHAR-DB |
Kv7.1
|
| Genes |
KCNQ1 (Hs), Kcnq1 (Mm), Kcnq1 (Rn) |
| Ensembl ID |
ENSG00000053918 (Hs), ENSMUSG00000009545 (Mm), ENSRNOG00000020532 (Rn)
|
|
Associated subunits
|
minK and MiRP2
|
| Inhibitors |
|
| Functional characteristics |
cardiac IK5
|
|
|
Kv7.2
Show »« Hide
| Nomenclature |
Kv7.2
|
| Other names |
KQT2,
Kv7.2,
KCNQ2,
EBN,
EBN1,
ENB1,
BFNC,
KCNA11,
HNSPC,
KQT-like 2,
potassium channel subunit alpha KvLQT2,
potassium voltage-gated channel subfamily KQT member 2,
potassium voltage-gated channel, KQT-like subfamily, member 2,
potassium voltage-gated channel, subfamily Q, member 2,
voltage-gated potassium channel subunit Kv7.2,
Nmf134
|
| IUPHAR-DB |
Kv7.2
|
| Genes |
KCNQ2 (Hs), Kcnq2 (Mm), Kcnq2 (Rn) |
| Ensembl ID |
ENSG00000075043 (Hs), ENSMUSG00000016346 (Mm), ENSRNOG00000011624 (Rn)
|
|
Associated subunits
|
minK
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
M current
|
|
|
Kv7.3
Show »« Hide
| Nomenclature |
Kv7.3
|
| Other names |
Kv7.3,
EBN2,
KQT-like 3,
potassium channel subunit alpha KvLQT3,
potassium voltage-gated channel subfamily KQT member 3,
potassium voltage-gated channel, subfamily Q, member 3,
voltage-gated potassium channel subunit Kv7.3
|
| IUPHAR-DB |
Kv7.3
|
| Genes |
KCNQ3 (Hs), Kcnq3 (Mm), Kcnq3 (Rn) |
| Ensembl ID |
ENSG00000184156 (Hs), ENSMUSG00000056258 (Mm), ENSRNOG00000005206 (Rn)
|
|
Associated subunits
|
minK
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
M current
|
|
|
Kv7.4
Show »« Hide
| Nomenclature |
Kv7.4
|
| Other names |
Kv7.4,
KCNQ4,
DFNA2,
KQT-like 4,
potassium channel subunit alpha KvLQT4,
potassium voltage-gated channel subfamily KQT member 4,
potassium voltage-gated channel, subfamily Q, member 4,
voltage-gated potassium channel subunit Kv7.4
|
| IUPHAR-DB |
Kv7.4
|
| Genes |
KCNQ4 (Hs), Kcnq4 (Mm), Kcnq4 (Rn) |
| Ensembl ID |
ENSG00000117013 (Hs), ENSMUSG00000028631 (Mm), ENSRNOG00000010576 (Rn)
|
|
Associated subunits
|
minK
|
Activators
(EC50) |
|
| Inhibitors |
|
|
|
Kv7.5
Show »« Hide
| Nomenclature |
Kv7.5
|
| Other names |
KCNQ5,
KvLQT5,
Kv7.5,
Kcnq5l,
LOC689123,
potassium voltage-gated channel subfamily KQT member 5,
potassium voltage-gated channel, KQT-like subfamily, member 5,
potassium voltage-gated channel, subfamily Q, member 5,
potassium voltage-gated channel, subfamily Q, member 5-like,
similar to Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel alpha subunit KvLQT5) (KQT-like 5),
D1Mgi1,
AA589396,
9230107O05Rik
|
| IUPHAR-DB |
Kv7.5
|
| Genes |
KCNQ5 (Hs), Kcnq5 (Mm), Kcnq5 (Rn) |
| Ensembl ID |
ENSG00000185760 (Hs), ENSMUSG00000028033 (Mm)
|
|
Associated subunits
|
minK
|
Activators
(EC50) |
|
| Inhibitors |
|
|
|
Kv8.1
Show »« Hide
| Nomenclature |
Kv8.1
|
| Other names |
kv2.3,
HNKA,
Kv8.1,
kv2.3r,
neuronal potassium channel alpha subunit,
potassium channel, subfamily V, member 1,
potassium voltage-gated channel subfamily V member 1,
voltage-gated potassium channel subunit Kv2.3r,
voltage-gated potassium channel subunit Kv8.1,
2700023A03Rik,
vibe
|
| IUPHAR-DB |
Kv8.1
|
| Genes |
KCNV1 (Hs), Kcnv1 (Mm), Kcnv1 (Rn) |
| Ensembl ID |
ENSG00000164794 (Hs), ENSMUSG00000022342 (Mm), ENSRNOG00000004117 (Rn)
|
|
|
Kv8.2
Show »« Hide
| Nomenclature |
Kv8.2
|
| Other names |
kv11.1,
Kv8.2,
Kcnv2_predicted,
LOC294065,
potassium channel, subfamily V, member 2,
potassium channel, subfamily V, member 2 (predicted),
potassium voltage-gated channel subfamily V member 2,
KV11.1
|
| IUPHAR-DB |
Kv8.2
|
| Genes |
KCNV2 (Hs), Kcnv2 (Mm), Kcnv2 (Rn) |
| Ensembl ID |
ENSG00000168263 (Hs), ENSMUSG00000047298 (Mm), ENSRNOG00000012566 (Rn)
|
|
|
Kv9.1
Show »« Hide
| Nomenclature |
Kv9.1
|
| Other names |
Kv9.1,
K+ voltage-gated channel, subfamily S, 1,
delayed-rectifier K(+) channel alpha subunit 1,
potassium voltage-gated channel subfamily S member 1,
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1,
voltage-gated potassium channel subunit Kv9.1
|
| IUPHAR-DB |
Kv9.1
|
| Genes |
KCNS1 (Hs), Kcns1 (Mm), Kcns1 (Rn) |
| Ensembl ID |
ENSG00000124134 (Hs), ENSMUSG00000040164 (Mm), ENSRNOG00000013681 (Rn)
|
|
|
Kv9.2
Show »« Hide
| Nomenclature |
Kv9.2
|
| Other names |
Kv9.2,
delayed-rectifier K(+) channel alpha subunit 2,
potassium channel, alpha subunit (kv9.2 gene),
potassium voltage-gated channel subfamily S member 2,
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2,
voltage-gated potassium channel subunit Kv9.2,
E130006J24Rik
|
| IUPHAR-DB |
Kv9.2
|
| Genes |
KCNS2 (Hs), Kcns2 (Mm), Kcns2 (Rn) |
| Ensembl ID |
ENSG00000156486 (Hs), ENSMUSG00000050963 (Mm), ENSRNOG00000011369 (Rn)
|
|
|
Kv9.3
Show »« Hide
| Nomenclature |
Kv9.3
|
| Other names |
Kv9.3,
Shab-related delayed-rectifier K+ channel (Kv9.3),
delayed-rectifier K(+) channel alpha subunit 3,
potassium voltage-gated channel subfamily S member 3,
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3,
voltage-gated potassium channel subunit Kv9.3,
D12Ertd137e
|
| IUPHAR-DB |
Kv9.3
|
| Genes |
KCNS3 (Hs), Kcns3 (Mm), Kcns3 (Rn) |
| Ensembl ID |
ENSG00000170745 (Hs), ENSMUSG00000043673 (Mm), ENSRNOG00000004899 (Rn)
|
|
|
Kv10.1
Show »« Hide
| Nomenclature |
Kv10.1
|
| Other names |
eag1a,
eag1b,
KCNH1a,
ether-a-go-go,
Kv10.1,
eag,
h-eag,
eag1,
EAG channel 1,
ether-a-go-go potassium channel 1,
potassium voltage-gated channel subfamily H member 1,
r-eag,
voltage-gated potassium channel subunit Kv10.1,
M-eag,
ether a go-go
|
| IUPHAR-DB |
Kv10.1
|
| Genes |
KCNH1 (Hs), Kcnh1 (Mm), Kcnh1 (Rn) |
| Ensembl ID |
ENSG00000143473 (Hs), ENSMUSG00000058248 (Mm)
|
|
Associated subunits
|
minK
|
|
|
Kv10.2
Show »« Hide
| Nomenclature |
Kv10.2
|
| Other names |
eag2,
KCNH5,
Kv10.2,
H-EAG2,
ether-a-go-go potassium channel 2,
potassium voltage-gated channel subfamily H member 5,
rEAG2,
voltage-gated potassium channel subunit Kv10.2
|
| IUPHAR-DB |
Kv10.2
|
| Genes |
KCNH5 (Hs), Kcnh5 (Mm), Kcnh5 (Rn) |
| Ensembl ID |
ENSG00000140015 (Hs), ENSMUSG00000034402 (Mm), ENSRNOG00000009542 (Rn)
|
|
Associated subunits
|
minK
|
|
|
Kv11.1
Show »« Hide
| Nomenclature |
Kv11.1
|
| Other names |
ether-à-go-go-related gene,
HERG,
erg1,
hergb,
LQT2,
Kv11.1,
ERG-1,
RERG,
eag-related protein 1,
ether-a-go-go-related gene potassium channel 1,
ether-a-go-go-related protein 1,
potassium voltage-gated channel subfamily H member 2,
r-ERG,
voltage-gated potassium channel subunit Kv11.1,
merg1a,
M-erg,
ether a go-go related,
LQT,
merg1b,
AI326795
|
| IUPHAR-DB |
Kv11.1
|
| Genes |
KCNH2 (Hs), Kcnh2 (Mm), Kcnh2 (Rn) |
| Ensembl ID |
ENSG00000055118 (Hs), ENSMUSG00000038319 (Mm), ENSRNOG00000009872 (Rn)
|
|
Associated subunits
|
minK and MiRP1
|
| Inhibitors |
|
| Functional characteristics |
cardiac IKR
|
|
|
Kv11.2
Show »« Hide
| Nomenclature |
Kv11.2
|
| Other names |
erg2,
KCNH6,
Kv11.2,
HERG2,
ERG-2,
Eag-related gene member 2,
eag-related protein 2,
ether-a-go-go-related gene potassium channel 2,
ether-a-go-go-related protein 2,
potassium voltage-gated channel subfamily H member 6,
voltage-gated potassium channel subunit Kv11.2,
m-erg2
|
| IUPHAR-DB |
Kv11.2
|
| Genes |
KCNH6 (Hs), Kcnh6 (Mm), Kcnh6 (Rn) |
| Ensembl ID |
ENSG00000173826 (Hs), ENSMUSG00000001901 (Mm), ENSRNOG00000008078 (Rn)
|
|
Associated subunits
|
minK
|
|
|
Kv11.3
Show »« Hide
| Nomenclature |
Kv11.3
|
| Other names |
erg3,
KCNH7,
Kv11.3,
HERG3,
ERG-3,
eag-related protein 3,
ether-a-go-go-related gene potassium channel 3,
ether-a-go-go-related protein 3,
potassium channel erg3,
potassium voltage-gated channel subfamily H member 7,
voltage-gated potassium channel subunit Kv11.3,
9330137I11Rik
|
| IUPHAR-DB |
Kv11.3
|
| Genes |
KCNH7 (Hs), Kcnh7 (Mm), Kcnh7 (Rn) |
| Ensembl ID |
ENSG00000184611 (Hs), ENSMUSG00000059742 (Mm), ENSRNOG00000007528 (Rn)
|
|
Associated subunits
|
minK
|
|
|
Kv12.1
Show »« Hide
| Nomenclature |
Kv12.1
|
| Other names |
elk1,
elk3,
Kv12.1,
Ets-1,
ELK channel 3,
ELK1, member of ETS oncogene family,
ether-a-go-go-like potassium channel 1,
ether-a-go-go-like potassium channel 3,
potassium voltage-gated channel subfamily H member 8,
potassium voltage-gated channel, subfamily H, member 8,
voltage-gated potassium channel subunit Kv12.1,
C130090D05Rik
|
| IUPHAR-DB |
Kv12.1
|
| Genes |
KCNH8 (Hs), Kcnh8 (Mm), Kcnh8 (Rn) |
| Ensembl ID |
ENSG00000183960 (Hs), ENSMUSG00000035580 (Mm), ENSMUSG00000073383 (Mm), ENSRNOG00000012711 (Rn)
|
|
Associated subunits
|
minK
|
|
|
Kv12.2
Show »« Hide
| Nomenclature |
Kv12.2
|
| Other names |
BEC1,
Elk2,
Kv12.2,
BEC1 protein,
ELK channel 2,
brain-specific eag-like channel 1,
ether-a-go-go-like potassium channel 2,
potassium voltage-gated channel subfamily H member 3,
rElk2,
voltage-gated potassium channel subunit Kv12.2,
Melk2,
ether a go-go like,
AU019351,
C030044P22Rik
|
| IUPHAR-DB |
Kv12.2
|
| Genes |
KCNH3 (Hs), Kcnh3 (Mm), Kcnh3 (Rn) |
| Ensembl ID |
ENSG00000135519 (Hs), ENSMUSG00000037579 (Mm), ENSRNOG00000032075 (Rn)
|
|
Associated subunits
|
minK
|
|
|
Kv12.3
Show »« Hide
| Nomenclature |
Kv12.3
|
| Other names |
BEC2,
Elk1,
Kv12.3,
ELK channel 1,
brain-specific eag-like channel 2,
ether-a-go-go-like potassium channel 1,
potassium voltage-gated channel subfamily H member 4,
rElk1,
voltage-gated potassium channel subunit Kv12.3
|
| IUPHAR-DB |
Kv12.3
|
| Genes |
KCNH4 (Hs), Kcnh4 (Mm), Kcnh4 (Rn) |
| Ensembl ID |
ENSG00000089558 (Hs), ENSMUSG00000035355 (Mm), ENSRNOG00000018790 (Rn)
|
|
Associated subunits
|
minK
|
|
Calcium-activated potassium channels
More information on this family may be found on the IUPHAR-DB family and introduction pages.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
|
KCa1.1
Show »« Hide
| Nomenclature |
KCa1.1
|
| Other names |
Slo,
Slo1,
BK channel,
maxi K+ channel,
KCa1.1,
KCNMA1,
mSLO1,
BK channel alpha subunit,
BKCa,
KCNMA1b,
KCNMA1c,
Kcnma,
BKCA alpha,
calcium-activated potassium channel alpha subunit,
calcium-activated potassium channel subunit alpha-1,
calcium-activated potassium channel, subfamily M subunit alpha-1,
k(VCA)alpha,
maxi K channel,
maxiK,
potassium large conductance calcium-activated channel, subfamily M, alpha member 1,
slo homolog,
slo-alpha,
slowpoke homolog,
5730414M22Rik
|
| IUPHAR-DB |
KCa1.1
|
| Genes |
KCNMA1 (Hs), Kcnma1 (Mm), Kcnma1 (Rn) |
| Ensembl ID |
ENSG00000156113 (Hs), ENSMUSG00000063142 (Mm), ENSRNOG00000005985 (Rn)
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
Maxi KCa, KNa (slack & slick)
|
|
|
KCa2.1
Show »« Hide
| Nomenclature |
KCa2.1
|
| Other names |
SK1,
SKCa1,
KCa2.1,
hSK1,
SKCa 1,
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1,
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like,
small conductance calcium-activated potassium channel protein 1,
AI854248
|
| IUPHAR-DB |
KCa2.1
|
| Genes |
KCNN1 (Hs), Kcnn1 (Mm), Kcnn1 (Rn) |
| Ensembl ID |
ENSG00000105642 (Hs), ENSMUSG00000002908 (Mm)
|
| Inhibitors |
|
| Functional characteristics |
SKCa
|
|
|
KCa2.2
Show »« Hide
| Nomenclature |
KCa2.2
|
| Other names |
SK2,
SKCa2,
KCa2.2,
hSK2,
SKCa 2,
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2,
small conductance calcium-activated channel, subfamily N, member 2,
small conductance calcium-activated potassium channel protein 2,
small conductance calcium-activated potassium channel 2,
fri
|
| IUPHAR-DB |
KCa2.2
|
| Genes |
KCNN2 (Hs), Kcnn2 (Mm), Kcnn2 (Rn) |
| Ensembl ID |
ENSG00000080709 (Hs), ENSMUSG00000054477 (Mm), ENSRNOG00000016675 (Rn)
|
| Inhibitors |
|
| Functional characteristics |
SKCa
|
|
|
KCa2.3
Show »« Hide
| Nomenclature |
KCa2.3
|
| Other names |
SK3,
SKCa3,
KCa2.3,
hSK3,
SKCa 3,
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3,
small conductance calcium-activated potassium channel protein 3,
small-conductance Ca2+-activated K+ channel 3,
small conductance calcium-activated potassium channel 3
|
| IUPHAR-DB |
KCa2.3
|
| Genes |
KCNN3 (Hs), Kcnn3 (Mm), Kcnn3 (Rn) |
| Ensembl ID |
ENSG00000143603 (Hs), ENSMUSG00000000794 (Mm), ENSRNOG00000020706 (Rn)
|
| Inhibitors |
|
| Functional characteristics |
SKCa
|
|
|
KCa3.1
Show »« Hide
| Nomenclature |
KCa3.1
|
| Other names |
SK41,
Ik1,
Gardos channel,
KCa4,
IKCa1,
KCa3.1,
KCa4,
IKCa1,
KCNN4,
hSK4,
hKCa4,
hIKCa1,
MGC156636,
rKCNN4c,
rSK4,
SK4,
SKCa 4,
SKCa4,
intermediate conductance K channel,
intermediate conductance calcium-activated potassium channel,
intermediate conductance calcium-activated potassium channel protein 4,
intermediate-conductance Ca-activated K channel,
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4,
mIKCa1
|
| IUPHAR-DB |
KCa3.1
|
| Genes |
KCNN4 (Hs), Kcnn4 (Mm), Kcnn4 (Rn) |
| Ensembl ID |
ENSG00000104783 (Hs), ENSMUSG00000054342 (Mm), ENSRNOG00000019440 (Rn)
|
| Inhibitors |
|
| Functional characteristics |
IKCa
|
|
|
KCa4.1
Show »« Hide
| Nomenclature |
KCa4.1
|
| Other names |
Slack,
Slo2.2,
KCNT1,
KCa4.1,
KIAA1422,
Slack,
rSlo2,
potassium channel subfamily T member 1,
potassium channel subunit (Slack),
potassium channel, subfamily T, member 1,
sequence like a calcium-activated potassium channel subunit,
slo2,
C030030G16Rik
|
| IUPHAR-DB |
KCa4.1
|
| Genes |
KCNT1 (Hs), Kcnt1 (Mm), Kcnt1 (Rn) |
| Ensembl ID |
ENSG00000107147 (Hs), ENSMUSG00000058740 (Mm), ENSRNOG00000017283 (Rn)
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
Maxi KCa KNa (slack & slick)
|
|
|
KCa4.2
Show »« Hide
| Nomenclature |
KCa4.2
|
| Other names |
Slick,
Slo2.1,
KCNT2,
KCa4.2,
SLICK,
SLO2.1,
sodium and chloride activated ATP sensitive potassium channel,
potassium channel subfamily T member 2,
potassium channel, subfamily T, member 2,
sequence like an intermediate conductance potassium channel subunit,
sodium and chloride-activated ATP-sensitive potassium channel Slo2.1,
sodium- and chloride-activated ATP-sensitive potassium channel,
E330038N15Rik
|
| IUPHAR-DB |
KCa4.2
|
| Genes |
KCNT2 (Hs), Kcnt2 (Mm), Kcnt2 (Rn) |
| Ensembl ID |
ENSG00000162687 (Hs), ENSMUSG00000052726 (Mm), ENSRNOG00000013312 (Rn)
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
Maxi KCa KNa (slack & slick)
|
|
|
KCa5.1
Show »« Hide
| Nomenclature |
KCa5.1
|
| Other names |
Slo3,
KCNMC1,
Kcnma3,
KCa5.1,
KCNU1,
LOC680912,
potassium channel subfamily U member 1,
potassium channel, subfamily U, member 1,
similar to Calcium-activated potassium channel alpha subunit 1 (Calcium-activated potassium channel, subfamily M, alpha subunit 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha)
|
| IUPHAR-DB |
KCa5.1
|
| Genes |
KCNU1 (Hs), Kcnu1 (Mm), Kcnu1 (Rn) |
| Ensembl ID |
ENSG00000215262 (Hs), ENSMUSG00000031576 (Mm)
|
Activators
(EC50) |
|
| Inhibitors |
|
| Functional characteristics |
Maxi KCa KNa (slack & slick)
|
|
Aguilar-Bryan, L; Clement, JP; Gonzalez, G; Kunjilwar, K; Babenko, A; Bryan, J. (1998) Toward understanding the assembly and structure of KATP channels.
Physiol. Rev., 78 (1): 227-45.
[PMID:9457174]
Ahern, CA; Kobertz, WR. (2009) Chemical tools for K(+) channel biology.
Biochemistry, 48 (3): 517-26.
[PMID:19113860]
Ashcroft, FM; Gribble, FM. (1998) Correlating structure and function in ATP-sensitive K+ channels.
Trends Neurosci., 21 (7): 288-94.
[PMID:9683320]
Bauer, CK; Schwarz, JR. (2001) Physiology of EAG K+ channels.
J. Membr. Biol., 182 (1): 1-15.
[PMID:11426295]
Bayliss, DA; Barrett, PQ. (2008) Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact.
Trends Pharmacol. Sci., 29 (11): 566-75.
[PMID:18823665]
Bean, BP. (2007) The action potential in mammalian central neurons.
Nat. Rev. Neurosci., 8 (6): 451-65.
[PMID:17514198]
Bezanilla, F. (2000) The voltage sensor in voltage-dependent ion channels.
Physiol. Rev., 80 (2): 555-92.
[PMID:10747201]
Dalby-Brown, W; Hansen, HH; Korsgaard, MP; Mirza, N; Olesen, SP. (2006) K(v)7 channels: function, pharmacology and channel modulators.
Curr Top Med Chem, 6 (10): 999-1023.
[PMID:16787276]
Enyedi, P; Czirják, G. (2010) Molecular background of leak K+ currents: two-pore domain potassium channels.
Physiol. Rev., 90 (2): 559-605.
[PMID:20393194]
Goldstein, SA; Bayliss, DA; Kim, D; Lesage, F; Plant, LD; Rajan, S. (2005) International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.
Pharmacol. Rev., 57 (4): 527-40.
[PMID:16382106]
Goldstein, SA; Bockenhauer, D; O'Kelly, I; Zilberberg, N. (2001) Potassium leak channels and the KCNK family of two-P-domain subunits.
Nat. Rev. Neurosci., 2 (3): 175-84.
[PMID:11256078]
Gutman, GA; Chandy, KG; Grissmer, S; Lazdunski, M; McKinnon, D; Pardo, LA; Robertson, GA; Rudy, B; Sanguinetti, MC; Stühmer, W; Wang, X. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
Pharmacol. Rev., 57 (4): 473-508.
[PMID:16382104]
Hancox, JC; McPate, MJ; El Harchi, A; Zhang, YH. (2008) The hERG potassium channel and hERG screening for drug-induced torsades de pointes.
Pharmacol. Ther., 119 (2): 118-32.
[PMID:18616963]
Hansen, JB. (2006) Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.
Curr. Med. Chem., 13 (4): 361-76.
[PMID:16475928]
Honoré, E. (2007) The neuronal background K2P channels: focus on TREK1.
Nat. Rev. Neurosci., 8 (4): 251-61.
[PMID:17375039]
Jenkinson, DH. (2006) Potassium channels--multiplicity and challenges.
Br. J. Pharmacol., 147 Suppl 1: S63-71.
[PMID:16402122]
Judge, SI; Bever, CT. (2006) Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment.
Pharmacol. Ther., 111 (1): 224-59.
[PMID:16472864]
Kaczorowski, GJ; Garcia, ML. (1999) Pharmacology of voltage-gated and calcium-activated potassium channels.
Curr Opin Chem Biol, 3 (4): 448-58.
[PMID:10419851]
Kannankeril, P; Roden, DM; Darbar, D. (2010) Drug-induced long QT syndrome.
Pharmacol. Rev., 62 (4): 760-81.
[PMID:21079043]
Kobayashi, T; Ikeda, K. (2006) G protein-activated inwardly rectifying potassium channels as potential therapeutic targets.
Curr. Pharm. Des., 12 (34): 4513-23.
[PMID:17168757]
Kubo, Y; Adelman, JP; Clapham, DE; Jan, LY; Karschin, A; Kurachi, Y; Lazdunski, M; Nichols, CG; Seino, S; Vandenberg, CA. (2005) International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.
Pharmacol. Rev., 57 (4): 509-26.
[PMID:16382105]
Lawson, K; McKay, NG. (2006) Modulation of potassium channels as a therapeutic approach.
Curr. Pharm. Des., 12 (4): 459-70.
[PMID:16472139]
Lesage, F. (2003) Pharmacology of neuronal background potassium channels.
Neuropharmacology, 44 (1): 1-7.
[PMID:12559116]
Lewis, RJ; Garcia, ML. (2003) Therapeutic potential of venom peptides.
Nat Rev Drug Discov, 2 (10): 790-802.
[PMID:14526382]
Lüscher, C; Slesinger, PA. (2010) Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.
Nat. Rev. Neurosci., 11 (5): 301-15.
[PMID:20389305]
Mannhold, R. (2006) Structure-activity relationships of K(ATP) channel openers.
Curr Top Med Chem, 6 (10): 1031-47.
[PMID:16787278]
Mathie, A; Veale, EL. (2007) Therapeutic potential of neuronal two-pore domain potassium-channel modulators.
Curr Opin Investig Drugs, 8 (7): 555-62.
[PMID:17659475]
Miller, C. (2003) A charged view of voltage-gated ion channels.
Nat. Struct. Biol., 10 (6): 422-4.
[PMID:12768203]
Nardi, A; Olesen, SP. (2008) BK channel modulators: a comprehensive overview.
Curr. Med. Chem., 15 (11): 1126-46.
[PMID:18473808]
Nichols, CG; Lopatin, AN. (1997) Inward rectifier potassium channels.
Annu. Rev. Physiol., 59: 171-91.
[PMID:9074760]
Pongs, O; Schwarz, JR. (2010) Ancillary subunits associated with voltage-dependent K+ channels.
Physiol. Rev., 90 (2): 755-96.
[PMID:20393197]
Reimann, F; Ashcroft, FM. (1999) Inwardly rectifying potassium channels.
Curr. Opin. Cell Biol., 11 (4): 503-8.
[PMID:10449331]
Robbins, J. (2001) KCNQ potassium channels: physiology, pathophysiology, and pharmacology.
Pharmacol. Ther., 90 (1): 1-19.
[PMID:11448722]
Salkoff, L; Butler, A; Ferreira, G; Santi, C; Wei, A. (2006) High-conductance potassium channels of the SLO family.
Nat. Rev. Neurosci., 7 (12): 921-31.
[PMID:17115074]
Sanguinetti, MC. (2000) Maximal function of minimal K+ channel subunits.
Trends Pharmacol. Sci., 21 (6): 199-201.
[PMID:10838601]
Seino, S; Miki, T. (2003) Physiological and pathophysiological roles of ATP-sensitive K+ channels.
Prog. Biophys. Mol. Biol., 81 (2): 133-76.
[PMID:12565699]
Stanfield, PR; Nakajima, S; Nakajima, Y. (2002) Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0.
Rev. Physiol. Biochem. Pharmacol., 145: 47-179.
[PMID:12224528]
Stocker, M. (2004) Ca(2+)-activated K+ channels: molecular determinants and function of the SK family.
Nat. Rev. Neurosci., 5 (10): 758-70.
[PMID:15378036]
Takeda, M; Tsuboi, Y; Kitagawa, J; Nakagawa, K; Iwata, K; Matsumoto, S. (2011) Potassium channels as a potential therapeutic target for trigeminal neuropathic and inflammatory pain.
Mol Pain, 7: 5.
[PMID:21219657]
Trimmer, JS; Rhodes, KJ. (2004) Localization of voltage-gated ion channels in mammalian brain.
Annu. Rev. Physiol., 66: 477-519.
[PMID:14977411]
Wang, H; Tang, Y; Wang, L; Long, CL; Zhang, YL. (2007) ATP-sensitive potassium channel openers and 2,3-dimethyl-2-butylamine derivatives.
Curr. Med. Chem., 14 (2): 133-55.
[PMID:17266574]
Weatherall, KL; Goodchild, SJ; Jane, DE; Marrion, NV. (2010) Small conductance calcium-activated potassium channels: from structure to function.
Prog. Neurobiol., 91 (3): 242-55.
[PMID:20359520]
Wei, AD; Gutman, GA; Aldrich, R; Chandy, KG; Grissmer, S; Wulff, H. (2005) International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.
Pharmacol. Rev., 57 (4): 463-72.
[PMID:16382103]
Wickenden, AD; McNaughton-Smith, G. (2009) Kv7 channels as targets for the treatment of pain.
Curr. Pharm. Des., 15 (15): 1773-98.
[PMID:19442190]
Witchel, HJ. (2007) The hERG potassium channel as a therapeutic target.
Expert Opin. Ther. Targets, 11 (3): 321-36.
[PMID:17298291]
Wulff, H; Castle, NA; Pardo, LA. (2009) Voltage-gated potassium channels as therapeutic targets.
Nat Rev Drug Discov, 8 (12): 982-1001.
[PMID:19949402]
Yellen, G. (2002) The voltage-gated potassium channels and their relatives.
Nature, 419 (6902): 35-42.
[PMID:12214225]
Yu, FH; Catterall, WA. (2004) The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis.
Sci. STKE, 2004 (253): re15.
[PMID:15467096]
@GuidetoPHARM 
Like us on Facebook 