Inwardly rectifying potassium channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

Channels and Subunits

Kir1.1 C Show summary » More detailed page

Kir2.1 C Show summary » More detailed page

Kir2.2 C Show summary » More detailed page

Kir2.3 C Show summary » More detailed page

Kir2.4 C Show summary » More detailed page

Kir3.1 C Show summary » More detailed page

Kir3.2 C Show summary » More detailed page

Kir3.3 C Show summary » More detailed page

Kir3.4 C Show summary » More detailed page

Kir4.1 C Show summary » More detailed page

Kir4.2 C Show summary » More detailed page

Kir5.1 C Show summary » More detailed page

Kir6.1 C Show summary » More detailed page

Kir6.2 C Show summary » More detailed page

Kir7.1 C Show summary » More detailed page

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Paul A. Slesinger, Colin G. Nichols, Lawrence G. Palmer, Henry Sackin, Stephen Tucker, John P. Adelman, David E. Clapham, Hiroshi Hibino, Atsushi Inanobe, Lily Y. Jan, Andreas Karschin, Yoshihiro Kubo, Yoshihisa Kurachi, Michel Lazdunski, Takashi Miki, Wade L. Pearson, Susumu Seino, Carol A. Vandenberg. Inwardly rectifying potassium channels. Accessed on 26/05/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=74.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Catterall WA, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels. Br J Pharmacol. 172: 5904-5941.