K<SUB>v</SUB>1.1 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

Kv1.1

Target id: 538

Nomenclature: Kv1.1

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kv1.1 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 495 12p13.32 KCNA1 potassium voltage-gated channel subfamily A member 1 45
Mouse 6 1 495 6 F1-F3 Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 18,36
Rat 6 1 495 4q42 Kcna1 potassium voltage-gated channel subfamily A member 1
Previous and Unofficial Names
HBK1 | Kcn1 | MBK1 | RCK1 | AEMK | HUK1 | Shak | Kcna | Kcpvd | potassium voltage-gated channel subfamily A member 1 | RBKI | Kca1-1 | mceph | MK1 | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | potassium channel, voltage gated shaker related subfamily A, member 1 | potassium voltage-gated channel
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Kv1.4 5,8,29,33
Kv1.2 5,8,29,42
Auxiliary Subunits
Name References
Kvβ2 5,28-29,34
Kvβ1 5,28-29,33
Other Associated Proteins
Name References
PSD95 5,17,39
SAP97 5,39
Lgi1 33
Associated Protein Comments
Other associated proteins are described in [5].
Functional Characteristics
KV
Ion Selectivity and Conductance
Species:  Mouse
Rank order:  K+ [10.0 pS]
References:  11
Species:  Rat
Rank order:  K+ [8.7 pS] > Rb+ [6.96 pS] > NH4+ [0.87 pS]
References:  37
Species:  Rat
Macroscopic current rectification:  Ik: Delayed Rectifier K+ current
References:  37
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -29.7 15.5 37 Xenopus laevis oocyte Rat
Inactivation  -47.0 83.4 37
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -32.0 - 11 L929 Mouse
Inactivation  - 14.0 11
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -37.2 - 14 Xenopus laevis oocyte Mouse
Inactivation  -49.1 2484.0 14

Download all structure-activity data for this target as a CSV file

Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
flecainide Mm - 3.7 pKd - - 11
pKd 3.7 [11]
tetraethylammonium Mm Inhibition 3.5 pKd - - 11
pKd 3.5 (Kd 3x10-4 M) [11]
α-dendrotoxin Rn - 7.7 – 9.0 pEC50 - - 11,15
pEC50 7.7 – 9.0 (EC50 2x10-8 – 9.6x10-10 M) [11,15]
HelaTx1 Hs Pore blocker 5.0 pEC50 - - 41
pEC50 5.0 (EC50 9.9x10-6 M) [41]
ShK Toxin Rn - 10.8 pIC50 - - 11
pIC50 10.8 [11]
hongotoxin-1 Rn - 10.5 pIC50 - - 21
pIC50 10.5 [21]
dendrotoxin-k Rn Pore blocker 8.6 pIC50 - - 31
pIC50 8.6 (IC50 2.5x10-9 M) [31]
margatoxin Hs Inhibition 8.4 pIC50 - - 3
pIC50 8.4 (IC50 4.2x10-9 M) [3]
margatoxin Rn Inhibition 8.3 pIC50 - - 20
pIC50 8.3 (IC50 5.46x10-9 M) [20]
dendrotoxin-I Mm - 7.7 pIC50 - - 11,31
pIC50 7.7 [11,31]
kaliotoxin Mm - 7.4 pIC50 - - 11
pIC50 7.4 [11]
mast cell degranulating peptide Mm - 6.3 pIC50 - - 11
pIC50 6.3 (IC50 4.9x10-7 M) [11]
resiniferatoxin Mm - 5.1 pIC50 - - 11
pIC50 5.1 [11]
capsaicin Mm - 4.5 pIC50 - - 11
pIC50 4.5 [11]
nifedipine Mm - 4.0 pIC50 - - 11
pIC50 4.0 [11]
diltiazem Mm - 3.8 pIC50 - - 11
pIC50 3.8 [11]
View species-specific channel blocker tables
Channel Blocker Comments
Arrangement of Kv1 subunits in heteromeric channels dictates TEA pharmacology [2]. Dendrotoxin-k is a selective inhibitor of Kv1.1 containing channels. IC50 for α-dendrotoxin blockade differs between Kv1.1 expressed in Xenopus oocytes and mammalian cells [12].
Tissue Distribution
Brain
Species:  Mouse
Technique:  In situ hybridisation
References:  38
Retina
Species:  Mouse
Technique:  In situ hybridisation
References:  19
Brain
Species:  Mouse
Technique:  Immunohistochemistry
References:  42,44
Brain
Species:  Rat
Technique:  Immunohistochemistry
References:  29
Brain > atrium > skeletal muscle >>> aorta
Species:  Rat
Technique:  Northern Blot
References:  30
Cerebellar cortex, deep cerebellar nuclei, Purkinje cells, granule cells, dentate gyrus, CA
Species:  Rat
Technique:  RT-PCR
References:  40
Medulla Pons, Superior Colliculus > Cerebellum, Inferior Colliculus, Midbrain devoid of the Colliculus > Cerebral cortex devoid of hippocampus and corpus striatum > Hippocampus > Olfactory bulb Corpus Striatum
Species:  Rat
Technique:  In situ hybridisation
References:  4
Skeletal and cardiac muscle
Species:  Rat
Technique:  In situ hybridisation
References:  24
Retina
Species:  Rat
Technique:  Immunocytochemistry, immunoelectron microscopy
References:  16
Functional Assays
Molecular cloning and voltage clamp
Species:  Mouse
Tissue:  Xenopus laevis Oocytes
Response measured:  Voltage-gated potassium currents, delayed rectifier
References:  11,38
Molecular cloning and voltage clamp
Species:  Rat
Tissue:  Xenopus laevis Oocytes
Response measured:  Voltage-gated potassium currents, delayed rectifier
References:  37
Molecular cloning and voltage clamp
Species:  Human
Tissue:  Xenopus laevis Oocytes
Response measured:  Voltage-gated potassium currents, delayed rectifier
References:  27
Physiological Functions
Determining action potential failure rate at nerve terminals
Species:  Mouse
Tissue:  Brain/cerebellum
References:  47-48
Maintaining membrane potential, modulating electrical excitability, spontaneous seizures, mortality
Species:  Mouse
Tissue:  Brain
References:  35,44
Phenotypes, Alleles and Disease Models Mouse data from MGI

Show »

Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0005402 abnormal action potential PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0005402 abnormal action potential PMID: 12611922 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002182 abnormal astrocyte morphology PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0004924 abnormal behavior PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0000913 abnormal brain development PMID: 8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002152 abnormal brain morphology PMID: 17250763  8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0002152 abnormal brain morphology PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0000771 abnormal brain size PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0004994 abnormal brain wave pattern PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0001544 abnormal cardiovascular system physiology PMID: 20392939 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0000788 abnormal cerebral cortex morphology PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002206 abnormal CNS synaptic transmission PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001406 abnormal gait PMID: 8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001963 abnormal hearing physiology PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001963 abnormal hearing physiology PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0003137 abnormal impulse conducting system conduction PMID: 20392939 
Kcna1+|Kcna1tm1Jmay Kcna1tm1Jmay/Kcna1+
B6.129S4-Kcna1
MGI:96654  MP:0002945 abnormal inhibitory postsynaptic currents PMID: 12612586 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0003492 abnormal involuntary movement PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0003492 abnormal involuntary movement PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001392 abnormal locomotor activity PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001392 abnormal locomotor activity PMID: 17250763 
Kcna1+|Kcna1tm1Jmay Kcna1tm1Jmay/Kcna1+
B6.129S4-Kcna1
MGI:96654  MP:0001516 abnormal motor coordination/ balance PMID: 12612586 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0002272 abnormal nervous system electrophysiology PMID: 12611922 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002918 abnormal paired-pulse facilitation PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0002913 abnormal PNS synaptic transmission PMID: 9736643 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001504 abnormal posture PMID: 17250763  8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001504 abnormal posture PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001961 abnormal reflex PMID: 8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002566 abnormal sexual interaction PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0001393 ataxia PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0010519 atrioventricular block PMID: 20392939 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0000947 convulsive seizures PMID: 14686897  17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0000947 convulsive seizures PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001265 decreased body size PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0001982 decreased chemically-elicited antinociception PMID: 9718989 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0008532 decreased chemical nociceptive threshold PMID: 9718989 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0005333 decreased heart rate PMID: 20392939 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0003483 decreased nerve fiber response threshold PMID: 12611922 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1
MGI:96654  MP:0003998 decreased thermal nociceptive threshold PMID: 9718989 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001849 ear inflammation PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001849 ear inflammation PMID: 17250763 
Kcna1tm1Jmay Kcna1tm1Jmay/Kcna1tm1Jmay
B6.129S4-Kcna1
MGI:96654  MP:0008762 embryonic lethality PMID: 12612586 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0008282 enlarged hippocampus PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0008282 enlarged hippocampus PMID: 17250763 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001349 excessive tearing PMID: 8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001851 eye inflammation PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001851 eye inflammation PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0001525 impaired balance PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0001522 impaired swimming PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0001994 increased blinking frequency PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0005238 increased brain size PMID: 14686896  8995755 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002176 increased brain weight PMID: 8995755 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0001488 increased startle reflex PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0001488 increased startle reflex PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0001488 increased startle reflex PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002906 increased susceptibility to pharmacologically induced seizures PMID: 9581771 
Kcna1+|Kcna1tm1Tem Kcna1tm1Tem/Kcna1+
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002906 increased susceptibility to pharmacologically induced seizures PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0000243 myoclonus PMID: 20392939 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0005654 porphyria PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0005654 porphyria PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0002082 postnatal lethality PMID: 20392939 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002083 premature death PMID: 9581771 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0002064 seizures PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0002064 seizures PMID: 14686897 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0002064 seizures PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0002064 seizures PMID: 20392939 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various
MGI:96654  MP:0003997 tonic-clonic seizures PMID: 9581771 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0003997 tonic-clonic seizures PMID: 14686897 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0003997 tonic-clonic seizures PMID: 20392939 
Kcna1mceph Kcna1mceph/Kcna1mceph
BALB/cByJ
MGI:96654  MP:0000745 tremors PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6
MGI:96654  MP:0000745 tremors PMID: 9736643 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ
MGI:96654  MP:0000745 tremors PMID: 17250763 
Kcna1tm1Tem Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd
MGI:96654  MP:0009732 ventricular premature beat PMID: 20392939 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Episodic ataxia, type 1; EA1
Synonyms: Episodic ataxia [Disease Ontology: DOID:963]
Hereditary continuous muscle fiber activity [Orphanet: ORPHA972]
Disease Ontology: DOID:963
OMIM: 160120
Orphanet: ORPHA972, ORPHA37612
References:  1,6,13,46
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human V174F Non-functional 1,6
Missense Human I177N 32
Missense Human F184C Altered gating 1
Missense Human T226R Reduced expression 49
Missense Human T226A 32
Missense Human T226K Reduced expression 7
Missense Human R239S Non-functional 6,46
Missense Human A242P Reduced expression 9
Missense Human P244H Similar to WT 9
Missense Human F249I Non-functional 6,46
Missense Human N255D Non-functional 10
Missense Human E325D Non-functional 1,6
Missense Human V404I Altered gating 9,32
Missense Human V408A Altered gating 1,6
Nonsense Human R417X Reduced expression/trafficking 9,23
Disease:  Isolated autosomal dominant hypomagnesemia, Glaudemans type
Orphanet: ORPHA199326
Clinically-Relevant Mutations and Pathophysiology Comments
Studies in mice have shown that a deletion/frameshift at I230* results in a non-functional protein leading to megencephaly and seizures [25-26].
Gene Expression and Pathophysiology
Increase
Tissue or cell type:  Heart
Pathophysiology:  Chronic heart rate reduction
Species:  Mouse
Technique:  RT-PCR on sample derived from mouse sino-atrial node. Mice previously dosed with ivabradine and monitored.
References:  22
Decrease
Tissue or cell type:  Pulmonary artery
Pathophysiology:  Chronic pulmonary artery hypoxia
Species:  Rat
Technique:  Analysis of gene expression in intact, endothelium denuded distal pulmonary arteries from rats exposed to varying levels of chronic hypoxia.
References:  43
Biologically Significant Variant Comments
A total of 246 SNPs have been identified in human KCNA1. For more information see the entry on GeneCards.
General Comments
Kv1.1 can coassemble with other Kv1 family members in heteromultimers but not with members of other Kv families. Arrangement of Kv1 subunits in a tetramer dictates pharmacology. Unique in that it has an intronless coding region. Part of the mammalian Shaker-related family. Kv1.1 KO mice have spontaneous recurrent seizures and premature death in a strain-dependent manner. Mutations lead to episodic ataxia in humans, and megacephaly in mice.

References

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1. Adelman JP, Bond CT, Pessia M, Maylie J. (1995) Episodic ataxia results from voltage-dependent potassium channels with altered functions. Neuron, 15 (6): 1449-54. [PMID:8845167]

2. Al-Sabi A, Shamotienko O, Dhochartaigh SN, Muniyappa N, Le Berre M, Shaban H, Wang J, Sack JT, Dolly JO. (2010) Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. J. Gen. Physiol., 136 (3): 273-82. [PMID:20805574]

3. Bartok A, Toth A, Somodi S, Szanto TG, Hajdu P, Panyi G, Varga Z. (2014) Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels. Toxicon, 87: 6-16. [PMID:24878374]

4. Beckh S, Pongs O. (1990) Members of the RCK potassium channel family are differentially expressed in the rat nervous system. EMBO J., 9 (3): 777-82. [PMID:2311579]

5. Bildl W, Haupt A, Müller CS, Biniossek ML, Thumfart JO, Hüber B, Fakler B, Schulte U. (2012) Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications. Mol. Cell Proteomics, 11 (2): M111.007955. [PMID:22067099]

6. Browne DL, Gancher ST, Nutt JG, Brunt ER, Smith EA, Kramer P, Litt M. (1994) Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. Nat. Genet., 8 (2): 136-40. [PMID:7842011]

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James S. Trimmer, K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv1.1. Last modified on 20/05/2015. Accessed on 19/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=538.