K<SUB>v</SUB>1.8 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

Kv1.8

Target id: 545

Nomenclature: Kv1.8

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kv1.8 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 511 1p13.1 KCNA10 potassium voltage-gated channel subfamily A member 10 6
Mouse 6 1 511 3 Kcna10 potassium voltage-gated channel, shaker-related subfamily, member 10
Rat 6 1 511 2q34 Kcna10 potassium voltage-gated channel subfamily A member 10
Previous and Unofficial Names
kv1.10 | Kcn1 | cyclic GMP gated potassium channel | KCNA10 | potassium voltage-gated channel subfamily A member 10 | Kcna8 | potassium channel, voltage gated shaker related subfamily A, member 10 | potassium voltage-gated channel
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Not determined
Auxiliary Subunits
Name References
KCNA4B 7
Other Associated Proteins
Name References
Not determined
Functional Characteristics
KV
Ion Selectivity and Conductance
Species:  Human
Rank order:  K+ [11.0 pS] > Na+ [0.15 pS]
References:  4
Species:  Human
Macroscopic current rectification:  Ik: Delayed Rectifier K+ current
References:  4
Ion Selectivity and Conductance Comments
K+/Na+ > 70:1;
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  3.6 18.0 4 Xenopus laevis oocyte Human
Inactivation  - 10000.0 4
Comments  Possibly a component of IKur in the heart
Associated subunits (Human)
Kv β1 and Kv β2

Download all structure-activity data for this target as a CSV file

Activator Comments
cGMP acts as an activator in rabbit [9]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
charybdotoxin Hs - 7.0 pIC50 - - 4
pIC50 7.0 [4]
pimozide Hs - 6.5 pIC50 - - 4
pIC50 6.5 [4]
ketoconazole Hs - 6.3 pIC50 - - 4
pIC50 6.3 [4]
verapamil Hs - 4.3 pIC50 - - 4
pIC50 4.3 [4]
fampridine Hs - 2.8 pIC50 - - 4
pIC50 2.8 (IC50 1.58x10-3 M) [4]
Ba2+ Hs - 2.3 pIC50 - - 4
pIC50 2.3 [4]
tetraethylammonium Hs - 1.3 pIC50 - - 4
pIC50 1.3 [4]
Tissue Distribution
Pulmonary artey smooth muscle cells
Species:  Human
Technique:  RT-PCR
References:  2
Kidney (cortex > medulla), brain, heart, skeletal muscle
Species:  Human
Technique:  Northern Blot
References:  3-4
Organ of Corti
Species:  Mouse
Technique:  In situ hybridisation
References:  1
Kidney (cortex > medulla), brain, heart, skeletal muscle
Species:  Rabbit
Technique:  Northern Blot
References:  8-9
Functional Assays
Molecular clone and voltage clamp
Species:  Human
Tissue:  Xenopus laevis oocytes
Response measured:  Kv1.8 mediates voltage-gated K+ currents that exhibit minimal steady-state inactivation
References:  4
Physiological Functions
Regulation of membrane potential in renal proximal tubules
Species:  Human
Tissue:  Kidney
References:  10
Biologically Significant Variant Comments
A total of 189 SNPs have been identified in human KCNA5. For more information please see the entry on GeneCards.
General Comments
Kv1.8 can co-assemble with other Kv1 family members, however it cannot do so with members of other Kv families.

It has an intronless coding region, like many other members of the family (except Kv1.7)

It is a member of the mammalian Shaker-related family. A null mutation leads to vestibular dysfunction [5].

References

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1. Carlisle FA, Steel KP, Lewis MA. (2012) Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti. Gene Expr. Patterns, 12 (5-6): 172-9. [PMID:22446089]

2. Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX. (2006) Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol., 291 (5): L993-1004. [PMID:16815889]

3. Iwasa H, Kurabayashi M, Nagai R, Nakamura Y, Tanaka T. (2001) Genetic variations in five genes involved in the excitement of cardiomyocytes. J. Hum. Genet., 46 (9): 549-52. [PMID:11558906]

4. Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV. (2000) KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am. J. Physiol. Renal Physiol., 278 (6): F1013-21. [PMID:10836990]

5. Lee SI, Conrad T, Jones SM, Lagziel A, Starost MF, Belyantseva IA, Friedman TB, Morell RJ. (2013) A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction. Hear. Res., 300: 1-9. [PMID:23528307]

6. Orias M, Bray-Ward P, Curran ME, Keating MT, Desir GV. (1997) Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics, 42 (1): 33-7. [PMID:9177773]

7. Tian S, Liu W, Wu Y, Rafi H, Segal AS, Desir GV. (2002) Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit. Am. J. Physiol. Renal Physiol., 283 (1): F142-9. [PMID:12060596]

8. Yao X, Liu Y, Tung F, Desir GV. (1996) Genomic structure and regulation of Kcn1, a cGMP-gated potassium channel. Am. J. Physiol., 271 (1 Pt 2): F37-41. [PMID:8760241]

9. Yao X, Segal AS, Welling P, Zhang X, McNicholas CM, Engel D, Boulpaep EL, Desir GV. (1995) Primary structure and functional expression of a cGMP-gated potassium channel. Proc. Natl. Acad. Sci. U.S.A., 92 (25): 11711-5. [PMID:8524834]

10. Yao X, Tian S, Chan HY, Biemesderfer D, Desir GV. (2002) Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule. J. Am. Soc. Nephrol., 13 (12): 2831-9. [PMID:12444201]

Contributors

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How to cite this page

James S. Trimmer, K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv1.8. Last modified on 14/10/2014. Accessed on 19/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=545.