K<SUB>v</SUB>5.1 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

Kv5.1

Target id: 555

Nomenclature: Kv5.1

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kv5.1 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 494 2p25 KCNF1 potassium voltage-gated channel modifier subfamily F member 1 4
Mouse 6 1 505 12 A1.1 Kcnf1 potassium voltage-gated channel, subfamily F, member 1
Rat 6 1 505 6q16 Kcnf1 potassium voltage-gated channel modifier subfamily F member 1
Previous and Unofficial Names
IK8 | KH1 | KCNF | potassium channel, voltage gated modifier subfamily F, member 1 | potassium channel, voltage-gated modifier subfamily F, member 1 | potassium voltage-gated channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifier
References: 
Tissue Distribution
Urinary bladder smooth muscle myocytes.
Species:  Mouse
Technique:  RT-PCR
References:  5
Skeletal muscle.
Species:  Rat
Technique:  Northern Blot
References:  1,5
Liver, kidney, pancreas.
Species:  Rat
Technique:  Northern Blot
References:  1,5
Heart.
Species:  Rat
Technique:  Northern Blot
References:  1,5
Brain: deeper cortical laters, piriform cortex, olfactory tubercule, medial habenular nucleus, medial amygdaloid nuclei, lateral amygdaloid area > hippocampus, dentate gyrus, zona incerta.
Species:  Rat
Technique:  In situ hybridisation
References:  1,5
Functional Assays
Voltage-clamp of KV2.1 and KV5.1 heteromultimers expressed in Xenopus oocytes.
Species:  Rat
Tissue:  Xenopus laevis oocytes.
Response measured:  Modulation of KV2.1 deactivation and inactivation.
References:  2
Physiological Functions
Modifies the gating properties of KV2.1 and KV2.2 channels.
Species:  Rat
Tissue:  Heteromultimers with KV2 subunits.
References:  2-3
Biologically Significant Variant Comments
A total of 105 SNPs have been identified in human KCNF1. For more information see the entry on GeneCards.
General Comments
KV5.1 has no function on its own, but has important modulatory actions on KV2 channels [2-3].

References

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1. Drewe JA, Verma S, Frech G, Joho RH. (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. J. Neurosci., 12 (2): 538-48. [PMID:1740690]

2. Kramer JW, Post MA, Brown AM, Kirsch GE. (1998) Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits. Am. J. Physiol., 274 (6 Pt 1): C1501-10. [PMID:9696692]

3. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels. J. Biol. Chem., 272 (39): 24371-9. [PMID:9305895]

4. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y. (1997) Isolation, characterization, and mapping of two human potassium channels. Biochem. Biophys. Res. Commun., 241 (3): 675-81. [PMID:9434767]

5. Verma-Kurvari S, Border B, Joho RH. (1997) Regional and cellular expression patterns of four K+ channel mRNAs in the adult rat brain. Brain Res. Mol. Brain Res., 46 (1-2): 54-62. [PMID:9191078]

Contributors

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How to cite this page

James S. Trimmer, K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv5.1. Last modified on 14/10/2014. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=555.