K<SUB>v</SUB>6.2 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

Kv6.2

Target id: 557

Nomenclature: Kv6.2

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kv6.2 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 0 466 18q22-q23 KCNG2 potassium voltage-gated channel modifier subfamily G member 2 5
Mouse 6 0 480 18 E3 Kcng2 potassium voltage-gated channel, subfamily G, member 2
Rat 6 0 480 18q12.3 Kcng2 potassium voltage-gated channel modifier subfamily G member 2
Previous and Unofficial Names
KCNF2 | KCNG2 | cardiac potassium channel subunit (Kv6.2) | potassium channel, voltage gated modifier subfamily G, member 2 | potassium voltage-gated channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Kv2.1 5
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
References: 
Tissue Distribution
Myocardium, fetal brain, germinal center B-cells
Species:  Human
Technique:  In situ hybridisation
References:  5
Pancreatic β cell
Species:  Human
Technique:  In situ hybridisation
References:  4
Pulmonary artery smooth muscle cell (PASMC)
Species:  Human
Technique:  RT-PCR
References:  1-2
Urinary bladder smooth muscle (UBSM) myocyte
Species:  Mouse
Technique:  RT-PCR
References:  3
Functional Assays
Molecular clone, patch clamp and yeast two-hybrid
Species:  Human
Tissue:  Myocardium cDNA exprsssed in Xenopus laevis oocytes
Response measured:  Formation of heteromultimeric Kv channels with Kv2.1 α subunits.
Kv2.1/Kv6.2 channels have submicromolar sensitivity to the antiarrhythmic drug propafenone. Suggests that delayed-rectifier type channels containing Kv6.2 subunits may contribute to cardiac action potential repolarization.
References:  5
Physiological Functions
Modifier / silencer, co-assembles with Kv2.1 producing K+ channels with unique properties.
Species:  Human
Tissue:  Myocardium cDNA exprsssed in Xenopus laevis oocytes
References:  5
Gene Expression and Pathophysiology
Ten-fold decrease of Kv6.2 mRNA expression in pulmonary artery smooth cells induced by Bone Morphogenetic Protein-2 (BMP-2)
Tissue or cell type:  Pulmonary artery smooth muscle cells (PASMC)
Pathophysiology:  Proliferation inhibition and apoptosis in normal human PASMC induced by BMP's
Species:  Human
Technique:  RT-PCR
References:  1
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  Modifier / silencer, co-assembles with Kv2.1 producing K+ channels with unique properties
Amino acids:  466
Nucleotide accession: 
Protein accession: 
References:  5
Biologically Significant Variant Comments
A total of 1190 SNPs have been identified in human KCNG2. For more information please see the entry on GeneCards.
General Comments
Kv6.2 has no function on its own, but plays a role in modulation of Kv2 channels.

References

Show »

1. Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX. (2006) Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol., 291 (5): L993-1004. [PMID:16815889]

2. Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX. (2004) Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol., 287 (1): L226-38. [PMID:15047570]

3. Thorneloe KS, Nelson MT. (2003) Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. J. Physiol. (Lond.), 549 (Pt 1): 65-74. [PMID:12679374]

4. Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG. (2004) Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes, 53 (3): 597-607. [PMID:14988243]

5. Zhu XR, Netzer R, Böhlke K, Liu Q, Pongs O. (1999) Structural and functional characterization of Kv6.2 a new gamma-subunit of voltage-gated potassium channel. Recept. Channels, 6 (5): 337-50. [PMID:10551266]

Contributors

Show »

How to cite this page

James S. Trimmer, K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv6.2. Last modified on 25/06/2015. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=557.