K<SUB>v</SUB>6.3 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

Kv6.3

Target id: 558

Nomenclature: Kv6.3

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kv6.3 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 436 2p21 KCNG3 potassium voltage-gated channel modifier subfamily G member 3 6
Mouse 6 1 433 17 E4 Kcng3 potassium voltage-gated channel, subfamily G, member 3 6
Rat 6 1 433 6q12 Kcng3 potassium voltage-gated channel modifier subfamily G member 3 6
Previous and Unofficial Names
Kv10.1 | voltage-gated potassium channel subunit Kv10.1 | voltage-gated potassium channel subunit Kv6.3 | Kv10.1a | Kv10.1b | potassium channel, voltage gated modifier subfamily G, member 3 | potassium voltage-gated channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
References: 
Tissue Distribution
Whole brain (amygdala, caudate nucleus, hippocampus, corpus callusum, substantia nugra, thalamus, frontal lobe, hypothalamus), testis, thymus, small intestine, spinal cord, pituitary and adrenal gland
Species:  Human
Technique:  RT-PCR
References:  2,4
Pancreas, brain, lung, kidney, ovary and colon
Species:  Human
Technique:  RT-PCR
References:  2
Pulmonary artery smooth muscle cells (PASMC)
Species:  Human
Technique:  RT-PCR
References:  1,3
Urinary bladder smooth muscle (UBSM) myocytes
Species:  Mouse
Technique:  RT-PCR
References:  5
Brain (cortex, olfactory cortical structures, basal ganglia / striatal structures, hippocampus and many nuclei of the amygdala complex)
Species:  Rat
Technique:  In situ hybridisation
References:  6
Functional Assays
Molecular clone, voltage clamp, yeast two-hybrid and co-immunoprecipitation
Species:  Human
Tissue:  Ltk- cells (mouse fibroblast cells)
Response measured:  Kv6.3 are "silent" subunits and form heterotetrameric channels with the Kv2 subfamily
References:  2,4
Physiological Functions
Modifier / silencer, co-assembles with Kv2.1
Species:  Human
Tissue:  L929 cells (murine fibroblast cells)
References:  4
Gene Expression and Pathophysiology
Significant upregulation ( > 2 fold) of Kv6.3 mRNA expression in pulmonary artery smooth muscle cells, induced by Bone Morphogenetic Proteins (BMPs)
Tissue or cell type:  Pulmonary artery smooth muscle cells
Pathophysiology:  Inhibition of proliferation and apoptosis in normal human PASMC
Species:  Human
Technique:  RT-PCR
References:  1
Biologically Significant Variants
Type:  Splice variant
Species:  Rat
Description:  Modulatory subunit of the voltage gated potassium channel
Amino acids:  433
Nucleotide accession: 
Protein accession: 
Type:  Splice variant
Species:  Rat
Description:  Modulatory subunit of the voltage gated potassium channel
Amino acids:  422
Nucleotide accession: 
Protein accession: 
Type:  Splice variant
Species:  Human
Description:  Kv6.3 has no function on its own, but has important modulatory actions on Kv2 channels
Amino acids:  425
Nucleotide accession: 
Protein accession: 
Type:  Splice variant
Species:  Human
Description:  Kv6.3 has no function on its own, but has important modulatory actions on Kv2 channels
Amino acids:  436
Nucleotide accession: 
Protein accession: 
Biologically Significant Variant Comments
A total of 1185 SNPs have been identified in human KCNG3. For more information see the entry on GeneCards.
General Comments
Kv6.3 is an electrically silent channel and has no function on its own. However, it has important modulatory actions on Kv2 channels.

References

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1. Fantozzi I, Platoshyn O, Wong AH, Zhang S, Remillard CV, Furtado MR, Petrauskene OV, Yuan JX. (2006) Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol., 291 (5): L993-1004. [PMID:16815889]

2. Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ. (2002) Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc. Natl. Acad. Sci. U.S.A., 99 (12): 7986-91. [PMID:12060745]

3. Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX. (2004) Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol., 287 (1): L226-38. [PMID:15047570]

4. Sano Y, Mochizuki S, Miyake A, Kitada C, Inamura K, Yokoi H, Nozawa K, Matsushime H, Furuichi K. (2002) Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. FEBS Lett., 512 (1-3): 230-4. [PMID:11852086]

5. Thorneloe KS, Nelson MT. (2003) Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. J. Physiol. (Lond.), 549 (Pt 1): 65-74. [PMID:12679374]

6. Vega-Saenz de Miera EC. (2004) Modification of Kv2.1 K+ currents by the silent Kv10 subunits. Brain Res. Mol. Brain Res., 123 (1-2): 91-103. [PMID:15046870]

Contributors

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How to cite this page

James S. Trimmer, K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv6.3. Last modified on 14/10/2014. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=558.