K<SUB>v</SUB>6.4 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 559

Nomenclature: Kv6.4

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 519 16q24.1 KCNG4 potassium voltage-gated channel modifier subfamily G member 4
Mouse 6 1 506 8 E1 Kcng4 potassium voltage-gated channel
Rat 6 1 506 19q12 Kcng4 potassium voltage-gated channel modifier subfamily G member 4
Previous and Unofficial Names
KV6.3 | potassium channel, voltage gated modifier subfamily G, member 4 | potassium voltage-gated channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
Tissue Distribution
Brain, liver, small intestine, colon
Species:  Human
Technique:  RT-PCR
References:  4
Functional Assays
Molecular clone, patch clamp, yeast two-hybrid and co-immunoprecipitation
Species:  Human
Tissue:  Ltk- cells (murine fibroblast cell line)
Response measured:  Kv6.4 are "silent" subunits and form heterotetrameric channels with the Kv2 subfamily
References:  1,4
Physiological Functions
Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium currents.
It modulates the activity of Kv2.1 channels by causing marked changes in activation threshold and kinetics, C-type inactivation, and deactivation.
Species:  Human
Tissue:  Ltk- cells
References:  4
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  Kv6.4 has no function on its own, but it has important modulatory actions on Kv2 channels
Amino acids:  519
Nucleotide accession: 
Protein accession: 
Biologically Significant Variant Comments
A total of 731 SNPs have been identified in human KCNG4. For more information, please see the entry on GeneCards.

This variant has questionable validity because it originates from a cancer cell line [3] :
  • RNA sequence: NM_133490
  • Protein sequence: NP_597997
  • Amino acids: 256
  • Type: Splice variant
  • Species: Human
  • General Comments
    Kv6.4 has no function on its own, but has important modulatory actions on Kv2 channels. Interaction with Kv2.1 is mediated by interactions between N- and C-termini [2].


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    1. Bocksteins E, Labro AJ, Snyders DJ, Mohapatra DP. (2012) The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels. PLoS ONE, 7 (5): e37143. [PMID:22615922]

    2. Bocksteins E, Mayeur E, Van Tilborg A, Regnier G, Timmermans JP, Snyders DJ. (2014) The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini. PLoS ONE, 9 (6): e98960. [PMID:24901643]

    3. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev., 57 (4): 473-508. [PMID:16382104]

    4. Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ. (2002) Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc. Natl. Acad. Sci. U.S.A., 99 (12): 7986-91. [PMID:12060745]


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    How to cite this page

    James S. Trimmer, K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
    Voltage-gated potassium channels: Kv6.4. Last modified on 14/10/2014. Accessed on 22/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=559.