K<SUB>v</SUB>9.1 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

Kv9.1

Target id: 567

Nomenclature: Kv9.1

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kv9.1 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 526 20q12 KCNS1 potassium voltage-gated channel modifier subfamily S member 1 3
Mouse 6 1 497 2 H3 Kcns1 K+ voltage-gated channel, subfamily S, 1
Rat 6 1 497 3q42 Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1
Previous and Unofficial Names
delayed-rectifier K(+) channel alpha subunit 1 | potassium voltage-gated channel, modifier subfamily S, member 1 | potassium voltage-gated channel | K+ voltage-gated channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Kv2 3
Auxiliary Subunits
Name References
Not determined
Other Associated Proteins
Name References
Not determined
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
References: 
Ion Selectivity and Conductance Comments
Electrically silent on its own.
Tissue Distribution
Infant brain, adult brain (frontal cortex), lens epithelium, melanocytes
Species:  Human
Technique:  RT-PCR
References:  3
Main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei, cerebellum.
Species:  Mouse
Technique:  Northern Blot, in situ hybridization
References:  2
Brain
Species:  Rat
Technique:  Northern Blot
References:  4
Tissue Distribution Comments
A very similar localization of Kv9 and Kv2 subunits has been observed at the cellular level in granular cells of the olfactory bulb, Purkinje and granular cells of the cerebellum, pyramidal cells of the hippocampus, and in granular cells of the dentate gyrus [2]
Physiological Functions
Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium current.
Kv9.1 modulates the activity of Kv2.1 and Kv2.2 α subunits by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarised values, and enhances the single-channel conductance of Kv2.1.
Species:  Mouse
Tissue:  COS m6 cells
References:  1-2
General Comments
The human Kv9.1 gene is composed of a minimum of 5 exons, with at least 2 alternatively spliced exons in the 5' - untranslated region [1-4].

References

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1. Richardson FC, Kaczmarek LK. (2000) Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunit. Hear. Res., 147 (1-2): 21-30. [PMID:10962170]

2. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels. J. Biol. Chem., 272 (39): 24371-9. [PMID:9305895]

3. Shepard AR, Rae JL. (1999) Electrically silent potassium channel subunits from human lens epithelium. Am. J. Physiol., 277 (3 Pt 1): C412-24. [PMID:10484328]

4. Stocker M, Kerschensteiner D. (1998) Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain. Biochem. Biophys. Res. Commun., 248 (3): 927-34. [PMID:9704029]

Contributors

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How to cite this page

K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv9.1. Last modified on 01/07/2010. Accessed on 18/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=567.