K<SUB>v</SUB>9.2 | Voltage-gated potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

Kv9.2

Target id: 568

Nomenclature: Kv9.2

Family: Voltage-gated potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Kv9.2 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 477 8p22 KCNS2 potassium voltage-gated channel modifier subfamily S member 2 1
Mouse 6 1 477 15 B3.1 Kcns2 K+ voltage-gated channel, subfamily S, 2
Rat 6 1 477 7q22 Kcns2 potassium voltage-gated channel, modifier subfamily S, member 2
Previous and Unofficial Names
delayed-rectifier K(+) channel alpha subunit 2 | potassium voltage-gated channel, modifier subfamily S, member 2 | potassium voltage-gated channel | K+ voltage-gated channel, subfamily S, 2 | K+ voltage-gated channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Ion Selectivity and Conductance
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
References: 
Voltage Dependence Comments
Electrically silent on its own, modulates properties of Kv2.1 in heterooligomers [3]
Tissue Distribution
Main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei, cerebellum, retina, spinal cord.
Species:  Mouse
Technique:  RT-PCR
References:  3
Pulmonary artery, brain
Species:  Rat
Technique:  RT-PCR
References:  2
Physiological Functions
Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium current.
Kv9.2 modulates the activity of Kv2.1 and Kv2.2 subunits by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values. Kv9.1 enhances the single-channel conductance of Kv2.1.
Species:  Mouse
Tissue:  Xenopus laevis oocytes
References:  3
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcns2tm1Lex Kcns2tm1Lex/Kcns2tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J
MGI:1197011  MP:0002169 no abnormal phenotype detected

References

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1. Banfi S, Borsani G, Rossi E, Bernard L, Guffanti A, Rubboli F, Marchitiello A, Giglio S, Coluccia E, Zollo M, Zuffardi O, Ballabio A. (1996) Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching. Nat. Genet., 13 (2): 167-74. [PMID:8640222]

2. Davies AR, Kozlowski RZ. (2001) Kv channel subunit expression in rat pulmonary arteries. Lung, 179 (3): 147-61. [PMID:11891605]

3. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels. J. Biol. Chem., 272 (39): 24371-9. [PMID:9305895]

Contributors

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How to cite this page

K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Voltage-gated potassium channels: Kv9.2. Last modified on 01/07/2010. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=568.