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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 1196 | 2q24.2 | KCNH7 | potassium voltage-gated channel subfamily H member 7 | |
| Mouse | 6 | 1 | 1195 | 2 C1.3 | Kcnh7 | potassium voltage-gated channel, subfamily H (eag-related), member 7 | |
| Rat | 6 | 1 | 1195 | 3q21 | Kcnh7 | potassium voltage-gated channel subfamily H member 7 | |
| Previous and Unofficial Names |
| erg3 | HERG3 | eag-related protein 3 | ether-a-go-go-related gene potassium channel 3 | potassium voltage-gated channel, subfamily H (eag-related), member 7 | potassium channel, voltage gated eag related subfamily H, member 7 | potassium voltage-gated channel |
| Database Links |
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| Alphafold | Q9NS40 (Hs), Q9ER47 (Mm), O54852 (Rn) |
| CATH/Gene3D | 2.60.120.10 |
| Ensembl Gene | ENSG00000184611 (Hs), ENSMUSG00000059742 (Mm), ENSRNOG00000007528 (Rn) |
| Entrez Gene | 90134 (Hs), 170738 (Mm), 170739 (Rn) |
| Human Protein Atlas | ENSG00000184611 (Hs) |
| KEGG Gene | hsa:90134 (Hs), mmu:170738 (Mm), rno:170739 (Rn) |
| OMIM | 608169 (Hs) |
| Pharos | Q9NS40 (Hs) |
| RefSeq Nucleotide | NM_173162 (Hs), NM_033272 (Hs), NM_133207 (Mm), NM_131912 (Rn) |
| RefSeq Protein | NP_775185 (Hs), NP_150375 (Hs), NP_573470 (Mm), NP_571987 (Rn) |
| UniProtKB | Q9NS40 (Hs), Q9ER47 (Mm), O54852 (Rn) |
| Wikipedia | KCNH7 (Hs) |
| Ion Selectivity and Conductance |
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| Voltage Dependence |
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| Voltage Dependence Comments | ||||||||||||||||||||
| Kv11.2 and Kv11.3 can form heteromultimers; for voltage dependence data see [11] |
| Associated subunits (Human) |
| minK (KCNE1) |
Download all structure-activity data for this target as a CSV file 
| Activators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Activator Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 10µM NS1643 produced a -15 to- 20mV shift in V0.5 of channel activation [1]. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Tissue Distribution
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| Tissue Distribution Comments | ||||||||
| Kv11.1, Kv11.2 and Kv11.3 channels are widely expressed throughout the nervous system [7,12]. All, with the exception of Kv11.1b isoform are transiently expressed in the developing spinal cord, largely within GABAergic neurons where they regulate nascent spinal motor rhythms [3]. All are expressed in adult brain in largely overlapping distributions and largely in neuron somata [4]. | ||||||||
| Physiological Functions
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| Clinically-Relevant Mutations and Pathophysiology
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| Biologically Significant Variants
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1. Bilet A, Bauer CK. (2012) Effects of the small molecule HERG activator NS1643 on Kv11.3 channels. PLoS ONE, 7 (11): e50886. [PMID:23226420]
2. Furlan F, Guasti L, Avossa D, Becchetti A, Cilia E, Ballerini L, Arcangeli A. (2005) Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro. Neuroscience, 135 (4): 1179-92. [PMID:16165280]
3. Furlan F, Taccola G, Grandolfo M, Guasti L, Arcangeli A, Nistri A, Ballerini L. (2007) ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord. J Neurosci, 27 (4): 919-28. [PMID:17251434]
4. Guasti L, Cilia E, Crociani O, Hofmann G, Polvani S, Becchetti A, Wanke E, Tempia F, Arcangeli A. (2005) Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits. J Comp Neurol, 491 (2): 157-74. [PMID:16127690]
5. Mühlbauer E, Bazwinsky I, Wolgast S, Klemenz A, Peschke E. (2007) Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell. Cell Mol Life Sci, 64 (6): 768-80. [PMID:17322986]
6. Schledermann W, Wulfsen I, Schwarz JR, Bauer CK. (2001) Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade. J Physiol (Lond.), 532 (Pt 1): 143-63. [PMID:11283231]
7. Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D, Dixon JE. (1997) Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci, 17 (24): 9423-32. [PMID:9390998]
8. Strauss KA, Markx S, Georgi B, Paul SM, Jinks RN, Hoshi T, McDonald A, First MB, Liu W, Benkert AR et al.. (2014) A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder. Hum Mol Genet, 23 (23): 6395-406. [PMID:24986916]
9. Sturm P, Wimmers S, Schwarz JR, Bauer CK. (2005) Extracellular potassium effects are conserved within the rat erg K+ channel family. J Physiol (Lond.), 564 (Pt 2): 329-45. [PMID:15705650]
10. Wanke E, Restano-Cassulini R. (2007) Toxins interacting with ether-à-go-go-related gene voltage-dependent potassium channels. Toxicon, 49 (2): 239-48. [PMID:17097705]
11. Wimmers S, Bauer CK, Schwarz JR. (2002) Biophysical properties of heteromultimeric erg K+ channels. Pflugers Arch, 445 (3): 423-30. [PMID:12466946]
12. Wymore RS, Gintant GA, Wymore RT, Dixon JE, McKinnon D, Cohen IS. (1997) Tissue and species distribution of mRNA for the IKr-like K+ channel, erg. Circ Res, 80 (2): 261-8. [PMID:9012748]
